NDAINJECTIONINJECTABLE
Approved
Sep 1972
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
4/8 — Partial
VIBRAMYCIN (doxycycline hyclate) by Pfizer is tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. Approved for acne vulgaris, sexually transmitted infections, helicobacter pylori infection. First approved in 1972.
Drug data last refreshed 18h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
VIBRAMYCIN (doxycycline hyclate) is a tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, delivering bacteriostatic activity against broad-spectrum Gram-positive and Gram-negative bacteria. It is indicated for acne vulgaris, sexually transmitted infections, and Helicobacter pylori infection. Doxycycline is readily absorbed orally, achieves peak serum levels within 2 hours, and is excreted primarily through the kidney with a half-life of 18-22 hours.
LOE Approaching
Product approaching loss of exclusivity with stable generic competition and modest team scaling; career growth limited to defensive market protection and generic lifecycle management.
Mechanism of Action
Tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form. Doxycycline is virtually completely absorbed after oral…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.