ERYC

LOE Approaching

erythromycin

NDAORALCAPSULE, DELAYED REL PELLETS
Approved
Jan 1981
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
11

Mechanism of Action

Mechanism of Action Erythromycin acts by inhibition of protein synthesis by binding 50 S ribosomal subunits of susceptible organisms. It does not affect nucleic acid synthesis. Resistance The major route of resistance is modification of the 23S rRNA in the 50S ribosomal subunit to insensitivity,…

Pharmacologic Class:

Macrolide

Clinical Trials (5)

NCT06948747Phase 1Completed

A Study to Investigate the Effect of AZD5004 on Rosuvastatin, Atorvastatin, Simvastatin, Repaglinide and the Effect of Erythromycin on AZD5004 in Healthy Participants

Started May 2025
49 enrolled
Healthy Participants
NCT06917872Phase 1Completed

A Study in Healthy People to Test Whether Erythromycin Influences the Amount of BI 1291583 in the Blood

Started Apr 2025
20 enrolled
Healthy
NCT05797753Phase 1Completed

A Study to Assess the Effect of Erythromycin on the Test Medicine (SAR443820) When Given Orally as Tablets to Healthy Adult Male and Female Participants (Part A); and the Effect of Itraconazole on the Test Medicine (SAR443820) When Given Orally as Capsules to Healthy Adult Male Participants (Part B)

Started Feb 2022
16 enrolled
Amyotrophic Lateral SclerosisHealthy Volunteer
NCT03480243Phase 1Completed

Study to Evaluate the Effect of Coadministered Erythromycin on the Pharmacokinetics and Safety of Padsevonil

Started Mar 2018
28 enrolled
Pharmacokinetics
NCT01589614Phase 1Completed

A Study To Investigate The Effect Of Erythromycin On The Pharmacokinetics Of PH-797804

Started Jun 2012
12 enrolled
Healthy