NDAOPHTHALMICSUSPENSION/DROPS
Approved
Mar 1998
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
11
Data completeness
6/8 — Strong
ALREX (loteprednol etabonate) by Bausch + Lomb is clinical pharmacology corticosteroids inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. Approved for ocular inflammation, inflammation, pain and 1 more indications. First approved in 1998.
Drug data last refreshed 20h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ALREX (loteprednol etabonate 0.2% ophthalmic suspension) is a corticosteroid eye drop manufactured by Bausch + Lomb, approved in 1998 for treating steroid-responsive inflammatory conditions of the eye including seasonal allergic conjunctivitis, iritis, cyclitis, and post-operative inflammation. The drug works by inhibiting phospholipase A2, reducing the release of inflammatory mediators like prostaglandins and leukotrienes. Unlike traditional corticosteroids, loteprednol etabonate is structurally modified to undergo predictable metabolism to inactive compounds, minimizing systemic absorption and potential adverse effects.
$0.0BPart D
Mechanism of Action
CLINICAL PHARMACOLOGY Corticosteroids inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen,…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.