Allergic Conjunctivitis

53
Pipeline Programs
12
Companies
50
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
12
0
24
16
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 53 programs with unclassified modality

On Market (1)

Approved therapies currently available

U
OLOPATADINE HYDROCHLORIDEApproved
olopatadine
Unknown Company
ophthalmic2015

Competitive Landscape

12 companies ranked by most advanced pipeline stage

Bausch + Lomb
Bausch + LombNJ - Bridgewater
15 programs
3
9
2
BepotastinePhase 4
Refresh Tears 0.5% Lubricant Eye DropsPhase 4
BeprevePhase 3
BeprevePhase 3
Brimonidine Tartrate 0.025%/Ketotifen Fumarate 0.035% Ophthalmic SolutionPhase 3
+10 more programs
Alcon
AlconFORT WORTH, TX
14 programs
1
3
3
7
AL-4943APhase 41 trial
OlopatadinePhase 45 trials
Olopatadine 0.1%Phase 41 trial
Olopatadine HCl ophthalmic solution, 0.1%Phase 41 trial
Olopatadine Hydrochloride Ophthalmic Solution, 0.2%Phase 41 trial
+9 more programs
Active Trials
NCT01326858Completed50Est. Jun 2011
NCT01001091Completed312Est. Apr 2010
NCT02079649Completed224Est. Jul 2014
+20 more trials
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
10 programs
1
6
2
BepotastinePhase 41 trial
Refresh Tears 0.5% Lubricant Eye DropsPhase 41 trial
Brimonidine Tartrate 0.025%/Ketotifen Fumarate 0.035% Ophthalmic SolutionPhase 31 trial
Brimonidine tartrate 0.025%/ketotifen fumarate 0.035%Phase 31 trial
EM-100Phase 31 trial
+5 more programs
Active Trials
NCT01339507Completed25Est. Jun 2011
NCT00375596Withdrawn0
NCT05815758Completed512Est. Sep 2023
+7 more trials
AbbVie
AbbVieNORTH CHICAGO, IL
2 programs
1
1
alacaftadine and naphazoline HCl & pheniramine maleatePhase 41 trial
AGN-229666Phase 21 trial
Active Trials
NCT01754766Completed90Est. Feb 2013
NCT01390961Unknown48Est. Jan 2012
M&
Merck & Co.RAHWAY, NJ
2 programs
2
ElestatPhase 4Small Molecule1 trial
epinastine HCL and olopatadine HCLPhase 41 trial
Active Trials
NCT00534794Completed79
NCT00489398Withdrawn25Est. Dec 2008
Thea Pharma
Thea PharmaMA - Waltham
1 program
1
NAABAK eyedropsPhase 41 trial
Active Trials
NCT01203540CompletedEst. Jan 2011
Faes Farma
Faes FarmaSpain - Leioa
3 programs
1
2
BilastinePhase 31 trial
Bilastine Ophthalmic Solution 0.6%Phase 31 trial
Bilastine 0.2%Phase 21 trial
Active Trials
NCT03231969Completed121Est. Oct 2017
NCT04810390Completed59Est. Nov 2022
NCT03479307Completed228Est. Aug 2018
S
SantenCA - Emeryville
2 programs
2
DE-114 ophthalmic solutionPhase 31 trial
DE-114 ophthalmic solutionPhase 31 trial
Active Trials
NCT01363713Completed130
NCT01363700Completed87
Regeneron
RegeneronTARRYTOWN, NY
2 programs
2
REGN5713Phase 31 trial
REGN5713Phase 31 trial
Active Trials
NCT06602739Completed54Est. Aug 2025
NCT07309432Recruiting350Est. Jun 2027
Marinomed Biotech
Marinomed BiotechAustria - Korneuburg
1 program
1
Eye Drops, Solution in Single-Dose ContainerPhase 21 trial
Active Trials
NCT04532710Completed64Est. May 2021
Takeda
TakedaTOKYO, Japan
1 program
1
LifitegrastPhase 25 trials
Active Trials
NCT02284516Completed711Est. Oct 2015
NCT01743729Completed720Est. Oct 2013
NCT01636206Completed332Est. Mar 2014
+2 more trials
VP
Vanda PharmaceuticalsWASHINGTON, DC
1 program
1
VSJ-110Phase 21 trial
Active Trials
NCT04622345Completed47Est. Jun 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
AlconOlopatadine HCl ophthalmic solution, 0.1%
AlconOlopatadine Hydrochloride Ophthalmic Solution, 0.2%
AbbViealacaftadine and naphazoline HCl & pheniramine maleate
AlconOlopatadine Hydrochloride Ophthalmic Solution, 0.2%
Bausch HealthBepotastine
Bausch HealthRefresh Tears 0.5% Lubricant Eye Drops
AlconOlopatadine hydrochloride, 0.1% ophthalmic solution
Thea PharmaNAABAK eyedrops
AlconAL-4943A
AlconOlopatadine Hydrochloride Ophthalmic Solution, 0.2%
AlconOlopatadine hydrochloride ophthalmic solution 0.1%
AlconOlopatadine
AlconOlopatadine
AlconOlopatadine
AlconOlopatadine

Showing 15 of 47 trials with date data

Clinical Trials (50)

Total enrollment: 11,388 patients across 50 trials

NCT02251613AlconOlopatadine HCl ophthalmic solution, 0.1%

Effectiveness of Olopatadine HCl Ophthalmic Solution for the Treatment of Allergic Conjunctivitis in Japan

Start: Dec 2013Est. completion: Jan 201450 patients
Phase 4Completed
NCT01697969AlconOlopatadine Hydrochloride Ophthalmic Solution, 0.2%

Confocal Analysis of Corneal Structures of Symptomatic Allergic Conjunctivitis Patients

Start: Sep 2012Est. completion: Jul 201317 patients
Phase 4Completed
NCT01390961AbbViealacaftadine and naphazoline HCl & pheniramine maleate

Comparison of Tolerability Between Two Allergy Drops

Start: Aug 2011Est. completion: Jan 201248 patients
Phase 4Unknown
NCT01272089AlconOlopatadine Hydrochloride Ophthalmic Solution, 0.2%

A Study of Patient Perception and Quality of Life Associated With the Use of Olopatadine 0.2% in Subjects With Allergic Conjunctivitis

Start: May 2011Est. completion: Dec 2011300 patients
Phase 4Completed

Use of BEPREVE (Bepotastine Besilate Ophthalmic Solution) 1.5% for Allergic Conjunctivitis and Contact Lenses

Start: May 2011Est. completion: Nov 201124 patients
Phase 4Unknown
NCT01346371Bausch HealthRefresh Tears 0.5% Lubricant Eye Drops

The Effect of BEPREVE 1.5% on Tear Film Osmolarity and Tear Film Lipid Layer

Start: May 2011Est. completion: Sep 201240 patients
Phase 4Completed
NCT01282138AlconOlopatadine hydrochloride, 0.1% ophthalmic solution

Assessment of Alcon's Ocular Image Quantification System

Start: Dec 2010Est. completion: Mar 201113 patients
Phase 4Completed
NCT01203540Thea PharmaNAABAK eyedrops

Evaluation of the Effect and Tolerance of Preservative Free NAAGA on the Inflammatory Component and Symptoms of Dry Eye Syndrome in Allergic Conjunctivitis Patients

Start: Oct 2010Est. completion: Jan 2011
Phase 4Completed

Patient Perception Study for AL-4943A

Start: Sep 2010Est. completion: Oct 201147 patients
Phase 4Completed
NCT01159769AlconOlopatadine Hydrochloride Ophthalmic Solution, 0.2%

Patient Perceptions and Quality of Life Associated With the Use of Olapatadine 0.2% for the Treatment of Allergic Conjunctivitis

Start: Jun 2010Est. completion: Aug 2010215 patients
Phase 4Completed
NCT01109485AlconOlopatadine hydrochloride ophthalmic solution 0.1%

Clinical Evaluation of 0.1% Olopatadine Hydrochloride Ophthalmic Solution in Pediatric Patients

Start: Mar 2010Est. completion: Jul 201142 patients
Phase 4Completed
NCT01119287AlconOlopatadine

Assessing the Efficacy of Maxidex® and Patanol® for the Treatment of Allergic Conjunctivitis

Start: Mar 2010Est. completion: Sep 2010180 patients
Phase 4Completed
NCT00979615AlconOlopatadine

Safety and Efficacy of Olopatadine 0.6% and Azelastine 137 Mcg in Vasomotor Rhinitis

Start: Sep 2009129 patients
Phase 4Completed
NCT00845195AlconOlopatadine

Comparison of Seasonal Allergic Rhinitis Treatment With 2 Antihistamines Used in Combination With Intranasal Corticosteroid

Start: Mar 2009150 patients
Phase 4Completed
NCT00789555AlconOlopatadine

Safety of PATANASE Nasal Spray in Patients With Perennial Allergic Rhinitis

Start: Nov 2008Est. completion: Jan 20111,260 patients
Phase 4Completed
NCT00818805AlconOlopatadine 0.1%

Efficacy Investigation Study of Olopatadine Hydrochloride Ophthalmic Solution Using OHIO Chamber in Patients With Seasonal Allergic Rhinitis (SAR)

Start: Jul 200850 patients
Phase 4Completed
NCT00691665AlconOlopatadine

Comparison of Olopatadine 0.6% and Fluticasone Proprionate 50mcg Nasal Sprays in a Two Week Seasonal Allergic Rhinitis Trial

Start: May 2008130 patients
Phase 4Completed

Study of Two Marketed Ocular Anti-Allergy Medications in Subjects With Allergic Conjunctivitis

Start: Oct 200779 patients
Phase 4Completed
NCT00489398Merck & Co.epinastine HCL and olopatadine HCL

Comparison of CL Wear Between Two Allergy Drops

Start: Jul 2007Est. completion: Dec 200825 patients
Phase 4Withdrawn
NCT00389025AlconOlopatadine

Mast-Cell Stabilizing Effects of Olopatadine

Start: Oct 200624 patients
Phase 4Completed
NCT01363700SantenDE-114 ophthalmic solution

Study of DE-114 Ophthalmic Solution in Patients With Allergic Conjunctivitis

87 patients
Phase 3Completed
NCT01363713SantenDE-114 ophthalmic solution

A Long-term Study of DE-114 Ophthalmic Solution in Patients With Allergic Conjunctivitis

130 patients
Phase 3Completed

Study of Bet v1 Antibodies Effect on Eye Allergy Symptoms in Adolescents and Adults With Birch Pollen Allergy

Start: Jan 2026Est. completion: Jun 2027350 patients
Phase 3Recruiting

A Study to Demonstrate the Effect of REGN5713-5715 on Reducing Ocular Allergy Signs and Symptoms in Adult Participants With Birch Pollen Allergy

Start: Nov 2024Est. completion: Aug 202554 patients
Phase 3Completed
NCT05815758Bausch HealthBrimonidine Tartrate 0.025%/Ketotifen Fumarate 0.035% Ophthalmic Solution

Evaluation of the Safety and Pharmacokinetics of Brimonidine Tartrate 0.025%/Ketotifen Fumarate 0.035% Combination Ophthalmic Solution

Start: Apr 2023Est. completion: Sep 2023512 patients
Phase 3Completed
NCT05579730Bausch HealthBrimonidine tartrate 0.025%/ketotifen fumarate 0.035%

Evaluation of Brimonidine Tartrate/Ketotifen Fumarate Combination for the Treatment of Allergic Conjunctivitis

Start: Oct 2022Est. completion: Jul 2023188 patients
Phase 3Completed

Study to Assess the Safety, Tolerability and Efficacy of Bilastine Ophthalmic Solution 0.6% in Children

Start: Mar 2021Est. completion: Nov 202259 patients
Phase 3Completed

A Single-Center Evaluation of the Relative Efficacy of EM-100 Compared to Zaditor® (Ketotifen Fumarate Ophthalmic Solution 0.035%) and Vehicle

Start: Apr 2018Est. completion: Apr 201865 patients
Phase 3Completed
NCT03479307Faes FarmaBilastine Ophthalmic Solution 0.6%

A Study Evaluating Bilastine Ophthalmic Solution 0.6% in the Conjunctival Allergen Challenge (Ora-CAC®) Model.

Start: Apr 2018Est. completion: Aug 2018228 patients
Phase 3Completed
NCT02322216AlconOlopatadine Hydrochloride Ophthalmic Solution 0.2%

Olopatadine Hydrochloride Ophthalmic Solution Study in Chinese Subjects

Start: Dec 2014Est. completion: Oct 2015383 patients
Phase 3Completed

A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3)

Start: Nov 2014Est. completion: Oct 2015711 patients
Phase 3Completed
NCT01743027AlconAL-4943A ophthalmic solution

Efficacy and Safety of an Ophthalmic Solution in Patients With Allergic Conjunctivitis

Start: Jan 2013Est. completion: Jul 2013902 patients
Phase 3Completed

A Phase 3 Study to Evaluate the Efficacy of Lifitegrast in Subjects With Dry Eye

Start: Dec 2012Est. completion: Oct 2013720 patients
Phase 3Completed

Safety Study of Lifitegrast to Treat Dry Eye

Start: Oct 2012Est. completion: Mar 2014332 patients
Phase 3Completed
NCT01698814AlconAL-4943A ophthalmic solution

A Six-Week Safety Study of an Investigational Ophthalmic Solution

Start: Oct 2012Est. completion: Jan 2013518 patients
Phase 3Completed
NCT01479374AlconOlopatadine Hydrochloride Ophthalmic Solution, 0.2%

Efficacy and Safety of AL-4943A Ophthalmic Solution in Patients With Allergic Conjunctivitis Using the Conjunctival Allergen Challenge (CAC) Model

Start: Jan 2012Est. completion: Mar 2012397 patients
Phase 3Completed

Safety and Efficacy Study of SAR 1118 to Treat Dry Eye Conducted in a Controlled Adverse Environment (CAE) (OPUS-1)

Start: Aug 2011Est. completion: Apr 2012588 patients
Phase 3Completed

Study Evaluating the Safety of KetoNaph Ophthalmic Solution in Healthy Volunteers

Start: Jul 2010Est. completion: Oct 2010534 patients
Phase 3Completed
NCT00770133Bausch HealthKetotifen/naphazoline

Ketotifen/Naphazoline Ophthalmic Solution in the Conjunctival Allergen Challenge Model of Acute Allergic Conjunctivitis.

Start: Feb 2010Est. completion: Jun 2010141 patients
Phase 3Completed
NCT01037179AlconOlopatadine Hydrochloride Ophthalmic Solution, 0.2%

An Open-Label, Long-Term Study With AL-4943A Ophthalmic Solution, 0.2% in Patients With Allergic Conjunctivitis

Start: Feb 2010Est. completion: May 2010110 patients
Phase 3Completed
NCT00987272AlconOlopatadine Hydrochloride Ophthalmic Solution, 0.2%

Study of Olopatadine HCl Ophthalmic Solutions Compared to Vehicle Using the Conjunctival Allergen Challenge (CAC) Model of Acute Allergic Conjunctivitis in Japanese Subjects

Start: Oct 2009Est. completion: Nov 2009267 patients
Phase 3Completed
NCT00769886Bausch HealthKetotifen/naphazoline

Ketotifen/Naphazoline Ophthalmic Solution in the Conjunctival Allergen Challenge Model of Allergic Conjunctivitis.

Start: Oct 2008Est. completion: Jun 2009144 patients
Phase 3Completed
NCT00331500AlconOlopatadine Hydrochloride Ophthalmic Solution, 0.2%

Olopatadine 0.2% for the Treatment of Allergic Conjunctivitis

Start: Apr 2006Est. completion: Jul 2006287 patients
Phase 3Completed
NCT00375596Bausch HealthKetotifen/vasoconstrictor

A Study Of The Safety And Effectiveness Of A New Treatment For Allergic Conjunctivitis

0
Phase 2Withdrawn

Safety and Efficacy of VSJ-110 in the Treatment of Allergic Conjunctivitis in Adults With a History of Ocular Allergies

Start: Nov 2020Est. completion: Jun 202147 patients
Phase 2Completed
NCT04532710Marinomed BiotechEye Drops, Solution in Single-Dose Container

Therapeutic Effect of Tacrosolv in Patients With Allergic Rhinoconjunctivitis

Start: Aug 2020Est. completion: May 202164 patients
Phase 2Completed
NCT03231969Faes FarmaBilastine 0.2%

A Single-Center, Phase 2 Study Evaluating Bilastine Ophthalmic Solution in the CAC® Model

Start: Jul 2017Est. completion: Oct 2017121 patients
Phase 2Completed
NCT02079649AlconAL-53817 Ophthalmic Solution, 0.1%

Safety and Efficacy Study of AL-53817 and AL-78843 Ophthalmic Solutions for Allergic Conjunctivitis

Start: Apr 2014Est. completion: Jul 2014224 patients
Phase 2Completed

AGN-229666 for the Treatment of Allergic Conjunctivitis

Start: Oct 2012Est. completion: Feb 201390 patients
Phase 2Completed
NCT01001091AlconAL-38583 ophthalmic solution

AL-38583 Ophthalmic Solution for Allergic Conjunctivitis Associated Inflammation

Start: Dec 2009Est. completion: Apr 2010312 patients
Phase 2Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

24 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 11,388 patients
12 companies competing in this space