Senior Director, Medical, Translational and Computational Pathologist

GSK is seeking a highly motivated Pathologist, preferable with industry experience to provide scientific, medical, and strategic leadership across translational and computational pathology. This role bridges traditional diagnostic pathology with advanced biomarker science, digital pathology, and AI‑enabled image analytics to support tissue‑based biomarker discovery, precision medicine, and diagnostic development from first‑in‑human studies through late‑stage clinical development. The candidate should be based in Philadelphia, USA or willing to relocate.

Key Responsibilities

Scientific, Medical, and Translational Leadership

• Provide timely, high‑quality pathology expertise to GSK leaders, scientists, and study teams, operating within GSK policies and regulatory frameworks.
• Guide and refine clinical development strategies across oncology (primary focus), respiratory, immunology, and infectious diseases, ensuring integration of histopathology, translational research, and precision medicine.
• Partner with biomarker scientists and translational research teams to enable rigorous biomarker strategies, including study selection, patient stratification, and hypothesis‑driven assay deployment.

Biomarker & Assay Development

• Provide strategic and scientific oversight of clinical biomarker assay development and validation, both internally and through external laboratories and CROs.
• Lead the development and deployment of innovative, clinical‑grade bioassays to support program needs, including:
  • Immunohistochemistry (IHC; conventional and multiplex/multicolor)
  • Multiplex immunofluorescence (mIF)
  • In situ hybridization (ISH)
  • Spatial ‘omics (high‑plex proteomics and/or transcriptomics)
  • Genomics (WGS, exome, bulk and single‑cell RNA‑seq, cfDNA)
  • Flow cytometry from tissue and liquid specimens (e.g., peripheral blood, pleural fluid)
• Ensure assay performance, analytical rigor, data interpretation, and regulatory readiness.

Clinical Development & Trial Support

• Provide direct pathology support to clinical development and translational medicine teams across programs.
• Advise on clinical trial design, execution, and governance, optimizing:
  • Diagnostic inclusion/exclusion criteria
  • Tissue collection strategies
  • Pathology endpoints and pathologic response assessments
  • Image and data asset generation
• Review and contribute to study protocols and key clinical documentation.
• Serve as a subject matter expert in interactions with health authorities, including preparation of regulatory submissions and responses, particularly for companion diagnostics.

Computational & Digital Pathology

• Drive computational pathology (CP) capabilities in collaboration with histotechnology, digital pathology, and AI/ML teams.
• Lead development of fit‑for‑purpose image analysis workflows and AI‑enabled models for quantification of high‑dimensional pathology data (e.g., histopathology images, spatial biology).
• Advance internal CP infrastructure, including whole‑slide imaging, QC review, metadata management, annotation strategies, and digital consensus workflows.
• Enable rapid, scalable data generation to support early through late‑phase clinical programs (Ph1–Ph3+).

External Engagement, Strategy & Leadership

• Support clinical trial advisory boards and engage external key opinion leaders to inform pathology‑related endpoints and strategy.
• Interface with clinical trial sites, external laboratories, CROs, and technology partners.
• Provide pathology input into external technology assessments, business development opportunities, and alliance management.
• Advise commercial and executive leadership on pathology, diagnostics, and biomarker‑related matters.
• Take on additional responsibilities as needed to meet evolving organizational priorities.

Basic Qualifications

• Medical Doctor
• Completion of formal postgraduate clinical training, clinical residency or specialty training in Pathology, Anatomic Pathology (AP) or AP/CP
• Fellowship or sub-specialty training in one or multiple surgical pathology and/or laboratory medicine disciplines.
• Minimum of 5+ years post-training experience in research, clinical practice, or industry.
• Experience with digital and computational pathology tools (e.g., HALO, Visiopharm) and strong interest in advancing CP applications.

Preferred Qualifications & Attributes

In addition to the above, the following would be preferred

• Medical Doctor + PhD
• Subspecialty expertise in surgical pathology relevant to GSK priorities (e.g., gynecologic, GU, head and neck, dermatopathology, soft tissue, hematopathology, pulmonary, renal, GI/liver).
• Experience in molecular pathology, genomics/NGS, flow cytometry, and/or immunopathology assay validation and clinical interpretation.
• Proven ability to manage multiple programs, work effectively in matrixed teams, and communicate clearly to diverse scientific, clinical, and leadership audiences.
• Demonstrated scholarly activity, hypothesis-driven research, and/or advanced degrees (MS, MPH, PhD).
• Experience in digital pathology, image analysis, AI/ML, data science, bioinformatics, or disease genetics.
• Track record of regulatory engagement and/or companion diagnostics development.
• Experience in laboratory leadership, quality systems, education, inspection, or CAP/RCP-related activities.
• Experience supporting clinical trials, protocol authorship, CRO interactions, and multinational matrix environments.

• If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $284,625 to $474,375. The US salary ranges take into account a number of factors including work location within the US market, the candidate’s skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process.

Please visit  GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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