Pharmacology Research Scientist

Job Description

The Human Disease Modelling group is recruiting a Research Scientist at the Oxford Research site to design and execute preclinical in vivo studies to prosecute targets across multiple therapeutic areas. The successful candidate will leverage expertise with genetically modified mouse models as well as other state-of-the-art in vivo techniques to test therapeutic hypotheses, develop translational readouts of efficacy and profile drug candidates. A crucial requirement of this position will be the ability to effectively balance being a hands-on laboratory scientist with evaluating different methodologies and contributing to scientific direction. Excellent communication skills will also be necessary to successfully collaborate across drug discovery functions to deliver impactful results. The role will provide an exciting opportunity for a motivated and innovative scientist to develop in vivo strategies, implement novel technologies and influence project direction.

Key Responsibilities

• Design and execute technically challenging experiments using disease-relevant genetically modified mouse models.
• Identify the best methodologies (in vivo, ex vivo, molecular biology/biochemistry) to develop novel readouts and models.
• Analyse complex datasets and communicate results clearly in the context of in vivo project strategy.
• Collaborate effectively with colleagues in the In Vivo Pharmacology team and other teams to enable cross-functional delivery.
• Maintain accurate records in line with internal and Home Office compliance standards.

Key Requirements

• Ph.D. with wet lab experience in a relevant field (e.g. biology, pharmacology) or equivalent experience in an industrial setting.
• Expertise with genetically modified mouse models and other in vivo techniques such as CRISPR editing, RNAi, viral transgene expression, electrophysiology or imaging. Practical skills in small animal handling, dosing and surgery.
• Proficient in molecular biology/ biochemistry techniques as applied to ex vivo tissue and biofluid samples including qPCR, western blotting, immunohistochemistry and ELISA.
• Self-motivated, proactive and adaptable with a proven ability to solve scientific problems and deliver high-quality results as evidenced through a strong publication record and/ or other significant individual contributions.
• Excellent communicator with demonstrable delivery through collaboration. Strong teamwork skills.
• Familiarity with the regulatory framework surrounding in vivo research.

Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.  

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com