Uremic Pruritus

Dermatology
5
Pipeline Programs
3
Companies
5
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
0
2
1
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

3 companies ranked by most advanced pipeline stage

CONMED
CONMEDCO - Greenwood Village
1 program
1
AST-120Phase 41 trial
Active Trials
NCT04639674CompletedEst. Aug 2022
Qilu Pharmaceutical
Qilu PharmaceuticalChina - Jinan
1 program
1
QLG2198Phase 31 trial
Active Trials
NCT06446310RecruitingEst. Aug 2025
Trevi Therapeutics
Trevi TherapeuticsNEW HAVEN, CT
3 programs
1
2
nalbuphine HCl ERPhase 2/31 trial
nalbuphine HCl ER tablets 60 mg BIDPhase 2/31 trial
Nalbuphine HCL ERPhase 11 trial
Active Trials
NCT02373215CompletedEst. Nov 2013
NCT02143973CompletedEst. Jan 2016
NCT02143648CompletedEst. Jul 2015

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
CONMEDAST-120
Qilu PharmaceuticalQLG2198
Trevi Therapeuticsnalbuphine HCl ER
Trevi Therapeuticsnalbuphine HCl ER tablets 60 mg BID
Trevi TherapeuticsNalbuphine HCL ER

Clinical Trials (5)

NCT04639674CONMEDAST-120

AST-120 in Hemodialysis Patients With Uremic Pruritus

Start: Jul 2020Est. completion: Aug 2022
Phase 4Completed
NCT06446310Qilu PharmaceuticalQLG2198

Phase 3 Study of QLG2198 in Haemodialysis Chinese Adult Subjects With Moderate-to-Severe Pruritus

Start: Jun 2024Est. completion: Aug 2025
Phase 3Recruiting
NCT02143973Trevi Therapeuticsnalbuphine HCl ER

Open Label Extension Study of Nalbuphine HCl ER in Hemodialysis Patients With Uremic Pruritus

Start: Sep 2014Est. completion: Jan 2016
Phase 2/3Completed
NCT02143648Trevi Therapeuticsnalbuphine HCl ER tablets 60 mg BID

Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus

Start: Jun 2014Est. completion: Jul 2015
Phase 2/3Completed
NCT02373215Trevi TherapeuticsNalbuphine HCL ER

Phase 1 Study of Nalbuphine HCl ER Tablets in Hemodialysis Patients With Uremic Pruritus

Start: Apr 2013Est. completion: Nov 2013
Phase 1Completed

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials
3 companies competing in this space

Related Indications

Dermatitis, Atopic(42)Hidradenitis Suppurativa(30)Chronic Spontaneous Urticaria(21)Alopecia Areata(17)Hidradenitis Suppurativa (HS)(10)Vitiligo(9)Rosacea(6)Chronic Urticaria(5)Pruritus(5)Androgenetic Alopecia(5)