Post-Traumatic Stress Disorder

9
Pipeline Programs
7
Companies
9
Clinical Trials
4
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
3
2
0
4
Early DiscoveryClinical DevelopmentMarket

On Market (4)

Approved therapies currently available

UP
KEPPRAApproved
levetiracetam
UCB Pharma
oral2003
UP
KEPPRA XRApproved
levetiracetam
UCB Pharma
oral2008
U
LEVETIRACETAMApproved
levetiracetam
Unknown Company
oral2012
U
SPRITAMApproved
levetiracetam
Unknown Company
oral2015

Competitive Landscape

7 companies ranked by most advanced pipeline stage

UP
UCB PharmaBelgium - Brussels
1 program
1
1
levetiracetamPhase 2/31 trial
Active Trials
NCT00413296Completed16Est. Mar 2008
Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
1 program
1
NabiximolsPhase 2/31 trial
Active Trials
NCT04592159Withdrawn0Est. Mar 2023
Precision BioSciences
1 program
1
60 mg PRAX-114 or 40 mg PRAX-114Phase 21 trial
Active Trials
NCT05260541Terminated11Est. Sep 2022
Praxis Precision Medicines
1 program
1
60 mg PRAX-114 or 40 mg PRAX-114Phase 2
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
1
BI 1358894Phase 21 trial
Active Trials
NCT05103657Completed318Est. Nov 2023
Alliance Pharmaceuticals
3 programs
Common Elements Treatment ApproachN/A1 trial
PARTS ProgramN/A2 trials
SeroquelN/A1 trial
Active Trials
NCT01856673Completed521Est. Jun 2014
NCT05095428Completed82Est. Nov 2023
NCT04713501Completed15Est. Jul 2021
+1 more trials
BrainsWay
BrainsWayJerusalem, Israel
1 program
Deep TMS SystemN/A1 trial
Active Trials
NCT02479906TerminatedEst. Mar 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Jazz PharmaceuticalsNabiximols
UCB Pharmalevetiracetam
Precision BioSciences60 mg PRAX-114 or 40 mg PRAX-114
Boehringer IngelheimBI 1358894
Alliance PharmaceuticalsPARTS Program
Alliance PharmaceuticalsPARTS Program
BrainsWayDeep TMS System
Alliance PharmaceuticalsCommon Elements Treatment Approach
Alliance PharmaceuticalsSeroquel

Clinical Trials (9)

Total enrollment: 997 patients across 9 trials

NCT04592159Jazz PharmaceuticalsNabiximols

Study of the Safety and Efficacy of Nabiximols Oromucosal Spray Versus Placebo in Patients With Post-traumatic Stress Disorder

Start: Feb 2021Est. completion: Mar 20230
Phase 2/3Withdrawn
NCT00413296UCB Pharmalevetiracetam

Levetiracetam in Post-Traumatic Stress Disorder

Start: Nov 2005Est. completion: Mar 200816 patients
Phase 2/3Completed
NCT05260541Precision BioSciences60 mg PRAX-114 or 40 mg PRAX-114

A Clinical Trial of PRAX-114 in Participants With Post-Traumatic Stress Disorder

Start: Jan 2022Est. completion: Sep 202211 patients
Phase 2Terminated
NCT05103657Boehringer IngelheimBI 1358894

A Study to Test Whether Taking BI 1358894 for 8 Weeks Helps Adults With Post-traumatic Stress Disorder

Start: Dec 2021Est. completion: Nov 2023318 patients
Phase 2Completed
NCT05095428Alliance PharmaceuticalsPARTS Program

Program for Alleviating and Resolving Trauma and Stress 2

Start: Apr 2022Est. completion: Nov 202382 patients
N/ACompleted
NCT04713501Alliance PharmaceuticalsPARTS Program

Program for Alleviating and Resolving Trauma and Stress 1

Start: Dec 2020Est. completion: Jul 202115 patients
N/ACompleted
NCT02479906BrainsWayDeep TMS System

A Safety & Efficacy Study With Deep Transcranial Magnetic Stimulation for the Treatment of Post-Traumatic Stress Disorder (PTSD)

Start: Nov 2016Est. completion: Mar 2020
N/ATerminated
NCT01856673Alliance PharmaceuticalsCommon Elements Treatment Approach

Evaluation of Two Community-based Mental Health Interventions for Violence-Displaced Afro-Descendants in Colombia.

Start: Jun 2012Est. completion: Jun 2014521 patients
N/ACompleted
NCT01066156Alliance PharmaceuticalsSeroquel

Post-Traumatic Stress Disorder (PTSD) and Seroquel

Start: Feb 2010Est. completion: Mar 201534 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

7 companies competing in this space