Osteoarthritis, Knee

25
Pipeline Programs
30
Companies
50
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
10
1
6
5
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
4100%
+ 34 programs with unclassified modality

On Market (1)

Approved therapies currently available

Bayer
ALEVE PMApproved
diphenhydramine hydrochloride and naproxen sodium
Bayer
oral2014

Competitive Landscape

29 companies ranked by most advanced pipeline stage

Bayer
BayerLEVERKUSEN, Germany
2 programs
1
1
ALEVE PM(Naproxen Sodium)Phase 25 trials
BPI 1000013N/A1 trial
Active Trials
NCT03556787Completed89Est. Nov 2018
NCT05485805Completed541Est. Jan 2024
NCT04307940Completed221Est. Oct 2020
+3 more trials
Astellas
AstellasChina - Shenyang
2 programs
1
1
Capsaicin Topical SolutionPhase 41 trial
CGS-200-1Phase 21 trial
Active Trials
NCT03528369Completed122Est. Dec 2018
NCT03124407Completed120Est. Oct 2016
Bioiberica
BioibericaSpain - Barcelona
1 program
1
DroglicanPhase 41 trial
Active Trials
NCT02821468Unknown20Est. Jun 2018
IBSA Institut Biochimique
IBSA Institut BiochimiqueSwitzerland - Lugano-Pazzallo
1 program
1
Sinovial®Phase 41 trial
Active Trials
NCT00556608Completed381Est. May 2010
T-Therapeutics
T-TherapeuticsUK - Cambridge
1 program
1
Transdermal Glucosamine CreamPhase 41 trial
Active Trials
NCT03743896CompletedEst. Mar 2017
Regeneron
RegeneronTARRYTOWN, NY
3 programs
1
1
1
FasinumabPhase 3Monoclonal Antibody
REGN475Phase 2/31 trial
FasinumabPhase 2Monoclonal Antibody
Active Trials
NCT02447276Completed421Est. Nov 2016
Teva
TevaIsrael - Petach Tikva
2 programs
1
1
FasinumabPhase 3Monoclonal Antibody5 trials
FasinumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT03949673Terminated23Est. Aug 2020
NCT03491904Completed100Est. Dec 2020
NCT03691974Completed180Est. Jan 2021
+3 more trials
GSK
GSKLONDON, United Kingdom
2 programs
1
1
GW406381Phase 31 trial
GW842166Phase 21 trial
Active Trials
NCT00447486Completed308
NCT00120900Completed1,340Est. Sep 2007
Axsome Therapeutics
Axsome TherapeuticsNY - New York
1 program
1
AXS-02Phase 31 trial
Active Trials
NCT02746068Unknown346Est. Dec 2020
Design Therapeutics
1 program
1
AmchafibrinPhase 31 trial
Active Trials
NCT03386656Completed150Est. May 2019
Anika Therapeutics
Anika TherapeuticsMA - Bedford
1 program
1
CingalPhase 31 trial
Active Trials
NCT04231318CompletedEst. May 2022
Bioventus
BioventusDURHAM, NC
2 programs
1
PTP-001Phase 21 trial
StimRouter Neuromodulation SystemN/A1 trial
Active Trials
NCT05644639Completed13Est. Jun 2024
NCT05100225Active Not Recruiting210Est. Nov 2022
Pfizer
PfizerNEW YORK, NY
2 programs
2
PF-04383119Phase 21 trial
PF-04457845Phase 21 trial
Active Trials
NCT00669409Completed83Est. Dec 2009
NCT00981357Completed76Est. May 2010
AB
A2 BiotherapeuticsCA - Agoura Hills
1 program
1
Bone marrow mesenchymal stem cellsPhase 21 trial
Active Trials
NCT05027581Completed72Est. Jun 2025
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
1
LY2951742Phase 21 trial
Active Trials
NCT02192190Terminated268Est. Jun 2015
Vivex Biologics
Vivex BiologicsGA - Atlanta
1 program
1
AlloGen LiquidPhase 11 trial
Active Trials
NCT04835389Withdrawn0Est. Jun 2022
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
1
JNJ-39439335; Placebo; NaproxenPhase 11 trial
Active Trials
NCT00933582Completed33Est. Jun 2010
M&
Merck & Co.RAHWAY, NJ
1 program
1
M6495Phase 11 trial
Active Trials
NCT03583346Completed32Est. Jul 2019
Medacta
MedactaSwitzerland - Castel San Pietro
2 programs
Kinematic alignmentN/A1 trial
Unicompartmental Knee ArthroplastyN/A1 trial
Active Trials
NCT03446391CompletedEst. May 2019
NCT03522025Active Not RecruitingEst. Dec 2026
AB
AP BiosciencesTaiwan - Taipei
1 program
BFRN/A1 trial
Active Trials
NCT05437770CompletedEst. Feb 2025
OD
1 program
Balanced Knee SystemN/A1 trial
Active Trials
NCT02362867CompletedEst. Jun 2019
Pierre Fabre
Pierre FabreFrance - Aignan
1 program
Chondroitin sulfateN/A1 trial
Active Trials
NCT06623773Completed151Est. Oct 2024
Opko Health
Opko HealthMIAMI, FL
1 program
ENKO 1N/A1 trial
Active Trials
NCT03762408Completed175Est. May 2020
Ferring Pharmaceuticals
Ferring PharmaceuticalsArgentina - Buenos Aires
1 program
EUFLEXXA™N/A1 trial
Active Trials
NCT00379236Completed588Est. May 2008
Cook Medical
Cook MedicalIN - Bloomington
1 program
EmbolizationN/A1 trial
Active Trials
NCT03884049Completed58Est. Jan 2023
Varian Medical Systems
1 program
Shoulder/Hip/Knee Embolization with Embozene MicrospheresN/A1 trial
Active Trials
NCT05700682RecruitingEst. Aug 2026
Ambrosia Biosciences
1 program
Solgar No7 ComplexN/A1 trial
Active Trials
NCT03442153UnknownEst. May 2018
Arthrex
1 program
Study of Patient Outcomes 5 Years After Partial Knee ReplacementN/A1 trial
Active Trials
NCT01620892CompletedEst. Apr 2015
C
CorinUK - Cirencester
1 program
Unity Knee™ TKR using measured resectionN/A1 trial
Active Trials
NCT03511144Withdrawn0Est. Jul 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
BayerNaproxen Sodium
AstellasCapsaicin Topical Solution
BioibericaDroglican
T-TherapeuticsTransdermal Glucosamine Cream
BayerNaproxen Sodium
IBSA Institut BiochimiqueSinovial®
BayerNaproxen Sodium
Anika TherapeuticsCingal
Design TherapeuticsAmchafibrin
TevaFasinumab
TevaFasinumab
TevaFasinumab
Axsome TherapeuticsAXS-02
BayerNaproxen Sodium
BayerNaproxen Sodium

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 13,865 patients across 50 trials

NCT04307940BayerNaproxen Sodium

Study to Collect Information on How Well the Study Drug Naproxen Sodium Tablets Works Compared to Hydrocodone/Acetaminophen Tablets in Order to Relieve Pain in Participants Experiencing Moderate to Severe Pain After Having Their Wisdom Teeth Removed

Start: Mar 2020Est. completion: Oct 2020221 patients
Phase 4Completed
NCT03124407AstellasCapsaicin Topical Solution

Osteoarthritis Knee Pain Relief Study of 0.25% 920-CGS-200

Start: Jul 2016Est. completion: Oct 2016120 patients
Phase 4Completed

Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN

Start: Jun 2016Est. completion: Jun 201820 patients
Phase 4Unknown
NCT03743896T-TherapeuticsTransdermal Glucosamine Cream

Transdermal Delivery of Glucosamine to the Synovial Fluid of Male and Female With Knee Osteoarthritis

Start: May 2016Est. completion: Mar 2017
Phase 4Completed
NCT01118273BayerNaproxen Sodium

Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine

Start: Jan 2008Est. completion: Feb 2008162 patients
Phase 4Completed

Efficacy Study of Intra-articular Hyaluronic Acid in the Knee Osteoarthritis

Start: Nov 2007Est. completion: May 2010381 patients
Phase 4Completed
NCT05485805BayerNaproxen Sodium

A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo

Start: Sep 2022Est. completion: Jan 2024541 patients
Phase 3Completed

Study of Cingal® and Triamcinolone Hexacetonide for the Relief of Knee Osteoarthritis Pain

Start: Sep 2020Est. completion: May 2022
Phase 3Completed

Efficacy and Safety of Topical Application of Tranexamic Acid for Saving Blood Losses in Patients Subjected to Prosthetic Knee Surgery

Start: Nov 2017Est. completion: May 2019150 patients
Phase 3Completed

Evaluate the Efficacy and Safety of Fasinumab in Patients With Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hip or Knee

Start: Oct 2017Est. completion: May 201963 patients
Phase 3Terminated

Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip

Start: Oct 2017Est. completion: Nov 20201,650 patients
Phase 3Completed

A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip

Start: Aug 2017Est. completion: Aug 20213,307 patients
Phase 3Completed

A Study to Assess the Efficacy and Safety of AXS-02 in Subjects With Knee OA Associated With Bone Marrow Lesions

Start: Mar 2016Est. completion: Dec 2020346 patients
Phase 3Unknown
NCT01495858BayerNaproxen Sodium

Evaluate Analgesic / Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain

Start: Dec 2011Est. completion: Feb 2012267 patients
Phase 3Completed
NCT01427803BayerNaproxen Sodium

Actual Use Trial of Naproxen Sodium

Start: Sep 2011Est. completion: Dec 2011778 patients
Phase 3Completed
NCT01383486BayerNaproxen Sodium

Self Selection Trial of Naproxen Sodium

Start: Jul 2011Est. completion: Aug 2011253 patients
Phase 3Completed
NCT01389284BayerNaproxen Sodium

Evaluate Efficacy and Safety of Extended Release (ER) Naproxen Sodium

Start: Jun 2011Est. completion: Sep 2011300 patients
Phase 3Completed
NCT01280591BayerNaproxen Sodium

Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine in Patients With Postsurgical Dental Pain

Start: Oct 2010Est. completion: Feb 2011712 patients
Phase 3Completed
NCT00751400BayerNaproxen Sodium

Naproxen Sodium Extended-Release Actual Use Study

Start: Jul 2008Est. completion: Nov 2008497 patients
Phase 3Completed

Evaluation of GW406381 in Treating Adults With Osteoarthritis Of The Knee

Start: May 2005Est. completion: Sep 20071,340 patients
Phase 3Completed

Study of REGN475 in Patients With Pain Due to Osteoarthritis of the Knee or Hip

Start: May 2015Est. completion: Nov 2016421 patients
Phase 2/3Completed
NCT05027581A2 BiotherapeuticsBone marrow mesenchymal stem cells

Chondrochymal® for Subjects With Knee Osteoarthritis (Knee OA)

Start: Oct 2021Est. completion: Jun 202572 patients
Phase 2Completed

Efficacy and Safety Trial of PTP-001 (MOTYS) for Symptomatic Knee Osteoarthritis

Start: Sep 2021Est. completion: Nov 2022210 patients
Phase 2Active Not Recruiting
NCT04132336BayerNaproxen Sodium

Study to Find Out the Optimal Dose of Caffeine in the Combination Tablet of Naproxen Sodium and Caffeine in Patients Experiencing Moderate to Severe Pain After Having Wisdom Teeth Removed

Start: Nov 2019Est. completion: Mar 2020193 patients
Phase 2Completed

Study to Evaluate Arthroplasty Specimens for Osteoarthritis of the Knee and Hip

Start: Apr 2019Est. completion: Aug 202023 patients
Phase 2Terminated

Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients With Pain Due to Osteoarthritis of the Hip or Knee

Start: Oct 2018Est. completion: Jan 2021180 patients
Phase 2Completed
NCT03570554BayerNaproxen Sodium

A Pilot Study Assessing the Treatment Responsiveness of a Novel Osteoarthritis Stiffness Scale

Start: Jun 2018Est. completion: Jun 201941 patients
Phase 2Completed

A Phase 2 Clinical Trial Examining the Effects on Osteoarthritic Knee Pain of CGS-200-1, CGS-200-5 and Vehicle Control

Start: May 2018Est. completion: Dec 2018122 patients
Phase 2Completed

A Study of LY2951742 in Participants With Mild to Moderate Osteoarthritis Knee Pain

Start: Jul 2014Est. completion: Jun 2015268 patients
Phase 2Terminated

A Study To Investigate Whether PF-04457845 Is Effective In Treating Pain, Is Safe And Tolerable In Patients With Osteoarthritis Of The Knee

Start: Nov 2009Est. completion: May 201076 patients
Phase 2Completed

A Phase 1/2A, Single Dose Study Of PF-04383119 In Japanese Patients With Moderate To Severe Pain From Osteoarthritis Of The Knee

Start: Jun 2008Est. completion: Dec 200983 patients
Phase 2Completed

A Study of GW842166 in Adults With Osteoarthritis Pain

Start: Apr 2007308 patients
Phase 2Completed

Study of AlloGen® Liquid Intra-articular Injection for Knee Osteoarthritis

Start: Jun 2021Est. completion: Jun 20220
Phase 1Withdrawn

To Assess the Patients' Ability to Self-Administer Fasinumab

Start: Jan 2019Est. completion: Dec 2020100 patients
Phase 1Completed

Multiple Ascending Doses (MAD) of Anti-A Disintegrin and Metalloproteinase With Thrombospondin Motifs-5 (Anti-ADAMTS-5) Nanobody in Participants With Knee Osteoarthritis (OA)

Start: Aug 2018Est. completion: Jul 201932 patients
Phase 1Completed
NCT03424135BayerNaproxen Sodium

A Pharmacokinetic Trial of Naproxen Sodium and Diphenhydramine Hydrochloride Soft Capsules Versus Naproxen Sodium and Diphenhydramine Hydrochloride Tablets in Healthy Adult Subjects Under Fed Conditions

Start: Mar 2018Est. completion: Apr 201860 patients
Phase 1Completed
NCT03396250BayerNaproxen Sodium

A Pharmacokinetic Trial of Naproxen Sodium and Diphenhydramine Hydrochloride Soft Capsules Versus Naproxen Sodium and Diphenhydramine Hydrochloride Tablets in Healthy Adult Subjects

Start: Feb 2018Est. completion: Mar 201836 patients
Phase 1Completed
NCT02229461BayerNaproxen Sodium

Naproxen Sodium/ASA Platelet Study

Start: Feb 2015Est. completion: May 2015117 patients
Phase 1Completed
NCT01666678BayerNaproxen Sodium

Compare Pharmacokinetic (PK) Profiles of Naproxen Sodium, Diphenhydramine Hydrochloride, and Naproxen Sodium and Diphenhydramine Hydrochloride Combination

Start: Jan 2012Est. completion: Mar 201232 patients
Phase 1Completed
NCT00933582Johnson & JohnsonJNJ-39439335; Placebo; Naproxen

A Clinical Study to Investigate the Effect on Pain Relief of a Single Dose of JNJ-39439335 in Patients With Chronic Osteoarthritis Pain of the Knee

Start: Aug 2009Est. completion: Jun 201033 patients
Phase 1Completed
NCT00818415BayerNaproxen Sodium

Naproxen Sodium ER Pharmacokinetic Study

Start: Nov 2008Est. completion: Nov 200832 patients
Phase 1Completed
NCT00751556BayerNaproxen Sodium

Single/Multiple Dose Bioavailability Trial

Start: Feb 2008Est. completion: Mar 200832 patients
Phase 1Completed
NCT00692016BayerNaproxen Sodium

Fast & Fed Pharmacokinetic (PK) Study

Start: Jan 2008Est. completion: Mar 200832 patients
Phase 1Completed
NCT02549469BayerNaproxen Sodium

Bioequivalence of Single Dose Extended Release Naproxen Sodium (660 mg) Tablet Versus Naproxen Sodium (220 mg) Tablet Three Times Daily

Start: Mar 2007Est. completion: May 200732 patients
Phase 1Completed
NCT05700682Varian Medical SystemsShoulder/Hip/Knee Embolization with Embozene Microspheres

Perfusion MRI-targeted Joint Embolization for Chronic Musculoskeletal Pain of the Shoulder, Hip and Knee

Start: Jul 2023Est. completion: Aug 2026
N/ARecruiting
NCT06623773Pierre FabreChondroitin sulfate

Study on Structum® in Adult Patients With Osteoarthritis (TRUST)

Start: Jun 2023Est. completion: Oct 2024151 patients
N/ACompleted
NCT05644639BioventusStimRouter Neuromodulation System

Study of StimRouter for Chronic Knee OA Pain

Start: Oct 2022Est. completion: Jun 202413 patients
N/ACompleted

Effects of Blood-flow Restricted Exercise Compared to Standard Rehabilitation in Patients With Knee Osteoarthritis

Start: Jan 2022Est. completion: Feb 2025
N/ACompleted

Neovascularization Embolisation for Knee Osteoarthritis.(NEO)

Start: Jun 2019Est. completion: Jan 202358 patients
N/ACompleted
NCT03522025MedactaUnicompartmental Knee Arthroplasty

GMK-UNI Anatomical UKA: Fixation of Cemented vs Cementless Designs

Start: Feb 2019Est. completion: Dec 2026
N/AActive Not Recruiting

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

6 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 13,865 patients
30 companies competing in this space