Skip to main content

Osteoarthritis, Knee

83
Pipeline Programs
30
Companies
50
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
16
5
32
2
17
11
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
867%
Monoclonal Antibody
433%
+ 161 programs with unclassified modality

On Market (1)

Approved therapies currently available

Pfizer
ACHES-N-PAINApproved
ibuprofen
Pfizer
oral1987

Competitive Landscape

86 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
9 programs
5
4
CelecoxibPhase 4Small Molecule1 trial
CelecoxibPhase 4Small Molecule1 trial
IbuprofenPhase 4Small Molecule1 trial
IbuprofenPhase 4Small Molecule1 trial
PF-04136309Phase 21 trial
+4 more programs
Active Trials
NCT00689273Completed159Est. Nov 2008
NCT01147458Terminated190Est. Feb 2011
NCT00981357Completed76Est. May 2010
+6 more trials
ViiV Healthcare
3 programs
1
1
1
ParacetamolPhase 4
GW406381Phase 3
GW842166Phase 2
Astellas
AstellasChina - Shenyang
2 programs
1
1
Capsaicin Topical SolutionPhase 41 trial
CGS-200-1Phase 21 trial
Active Trials
NCT03528369Completed122Est. Dec 2018
NCT03124407Completed120Est. Oct 2016
Palm Therapeutics
1
Capsaicin Topical SolutionPhase 4
KiOmed Pharma
1 program
1
KiOmedine® CM-ChitosanPhase 41 trial
Active Trials
NCT05214807Unknown104Est. Feb 2024
Ache Laboratorios Farmaceuticos
1
MotorePhase 41 trial
Active Trials
NCT02409381Completed288Est. Jun 2016
Lipogems International
1
injection of autologous micro-fragmented adipose tissuePhase 41 trial
Active Trials
NCT03117608Unknown118Est. Feb 2024
Yooyoung Pharmaceutical
2
1
2
YYC301-1 & YYC301-2 & YYC301-3Phase 31 trial
YYD302 2mlPhase 31 trial
Celecoxib 200mgPhase 21 trial
YY1201 2mlPhase 1/21 trial
YYD302 2mlPhase 1/21 trial
+1 more programs
Active Trials
NCT05348525Unknown54Est. Mar 2023
NCT02554552Withdrawn0Est. Oct 2016
NCT02965495Completed30Est. Sep 2017
+3 more trials
Biocorp
5 programs
1
1
GID SVF-2 Device SystemPhase 3
Bone marrow mesenchymal stem cellsPhase 2
MegaCarti®N/A1 trial
MegaCarti®N/A1 trial
MegaCarti®N/A1 trial
Active Trials
NCT06278480Completed40Est. Mar 2024
NCT05440370Active Not Recruiting90Est. Jan 2027
NCT06249828Completed61Est. Dec 2025
Sorrento Therapeutics
1
1
2
ResiniferatoxinPhase 31 trial
ResiniferatoxinPhase 31 trial
ResiniferatoxinPhase 21 trial
ResiniferatoxinPhase 11 trial
Active Trials
NCT03542838Completed94Est. Feb 2021
NCT04885972Unknown124Est. Nov 2023
NCT04386980Withdrawn0Est. Jun 2022
+1 more trials
Sandoz
SandozAustria - Kundl
4 programs
2
2
LumiracoxibPhase 3Small Molecule
diclofenac diethylamine, DDEA 2.32% gelPhase 3
QUC398Phase 2
RHH646Phase 2
Colorado Therapeutics
1
DronabinolPhase 31 trial
Knee OsteoarthritisN/A1 trial
PB125N/A1 trial
Active Trials
NCT02664896Completed187Est. May 2016
NCT04638387Terminated4Est. Sep 2021
NCT04298528Unknown460Est. Feb 2025
Paradigm Biopharmaceuticals
1
1
Pentosan Polysulfate Sodium twice weeklyPhase 3
Pentosan Polysulfate Sodium twice weeklyPhase 2/3
Pentosan Polysulphate SodiumN/A
Paradigm Therapeutics
1
1
Pentosan Polysulfate Sodium twice weeklyPhase 31 trial
Pentosan Polysulfate Sodium twice weeklyPhase 2/31 trial
Pentosan Polysulphate SodiumN/A1 trial
Active Trials
NCT04814719Completed133Est. Dec 2024
NCT04809376Active Not Recruiting602Est. Jan 2025
NCT06917404Recruiting466Est. Jul 2027
Centrexion Therapeutics
1
1
CNTX-4975-05Phase 31 trial
Ice Pack and Cooling DevicePhase 11 trial
Active Trials
NCT03472677Completed20Est. Aug 2018
NCT03429049Completed332Est. Nov 2019
Axsome Therapeutics
Axsome TherapeuticsNY - New York
2 programs
2
AXS-02Phase 31 trial
zoledronatePhase 31 trial
Active Trials
NCT02746068Unknown346Est. Dec 2020
NCT02504008Unknown190Est. Jan 2019
Design Pharmaceuticals
1
AmchafibrinPhase 3
Anika Therapeutics
1
CingalPhase 31 trial
Active Trials
NCT04231318Completed231Est. May 2022
GID Bio
1 program
1
GID SVF-2 Device SystemPhase 31 trial
Active Trials
NCT04440189Active Not Recruiting114Est. Jun 2025
Nordic Pharma
6 programs
1
1
SpriferminPhase 21 trial
AllocetraPhase 1/21 trial
Cycling then runningN/A1 trial
Device: Robotic MAKO total kneeN/A1 trial
Ergometer Cycling followed by treadmill runningN/A1 trial
+1 more programs
Active Trials
NCT04542668Completed40Est. Jun 2021
NCT05744895Completed123Est. Jun 2025
NCT04542655Completed40Est. May 2019
+3 more trials
Xalud Therapeutics
3
1
XT-150Phase 21 trial
XT-150Phase 11 trial
XT-150Phase 11 trial
XT-150Phase 11 trial
Active Trials
NCT03769662Completed16Est. Dec 2019
NCT03282149Completed24Est. Jun 2019
NCT03477487Completed32Est. Sep 2019
+1 more trials
Prevail Therapeutics
3
LY2828360Phase 2
LY2951742Phase 2
LY3016859 ISAPhase 2
Kolon TissueGene
1
1
TissueGene-CPhase 21 trial
TissueGene-CPhase 11 trial
Active Trials
NCT00599248Completed12Est. May 2010
NCT01221441Completed102Est. Oct 2014
Dong-A ST
2 programs
2
DA-5202 20mgPhase 21 trial
SI000413Phase 21 trial
Active Trials
NCT02554240Completed115Est. Oct 2016
NCT01525758Unknown152Est. Dec 2013
Medivir
2 programs
2
MIV-711Phase 21 trial
MIV-711Phase 21 trial
Active Trials
NCT03037489Completed50Est. Nov 2017
NCT02705625Completed244Est. May 2017
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
Adalimumab 40 mgPhase 21 trial
Active Trials
NCT02471118Completed62Est. Mar 2021
Marius Pharmaceuticals
1 program
1
GLA:DPhase 21 trial
Active Trials
NCT03843931Completed206Est. Dec 2020
Cytopeutics
1 program
1
Human umbilical cord-derived mesenchymal stem cellsPhase 21 trial
Active Trials
NCT05016011Completed28Est. Mar 2022
Menarini
1 program
1
MEN16132 - 0.125 mgPhase 21 trial
Active Trials
NCT01091116Completed423Est. Mar 2011
Ono Pharmaceutical
1
ONO-4474Phase 21 trial
Active Trials
NCT02997696Terminated70Est. Jan 2018

+56 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
KiOmed PharmaKiOmedine® CM-Chitosan
Lipogems Internationalinjection of autologous micro-fragmented adipose tissue
AstellasCapsaicin Topical Solution
BioibericaDroglican
T-TherapeuticsTransdermal Glucosamine Cream
Ache Laboratorios FarmaceuticosMotore
IBSA Institut BiochimiqueSinovial®
PfizerCelecoxib
PfizerCelecoxib
PfizerIbuprofen
PfizerIbuprofen
Paradigm TherapeuticsPentosan Polysulfate Sodium twice weekly
Yooyoung PharmaceuticalYYC301-1 & YYC301-2 & YYC301-3
Sorrento TherapeuticsResiniferatoxin
Sorrento TherapeuticsResiniferatoxin

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 17,528 patients across 50 trials

NCT05214807KiOmed PharmaKiOmedine® CM-Chitosan

Long-term Safety and Performance of KiOmedine CM-Chitosan Supplementation in Advanced Symptomatic Knee Osteoarthritis

Start: Jan 2022Est. completion: Feb 2024104 patients
Phase 4Unknown
NCT03117608Lipogems Internationalinjection of autologous micro-fragmented adipose tissue

A Single Intra-articular Injection of aMAT vs PRP in Patients With OA of the Knee

Start: Feb 2017Est. completion: Feb 2024118 patients
Phase 4Unknown
NCT03124407AstellasCapsaicin Topical Solution

Osteoarthritis Knee Pain Relief Study of 0.25% 920-CGS-200

Start: Jul 2016Est. completion: Oct 2016120 patients
Phase 4Completed

Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN

Start: Jun 2016Est. completion: Jun 201820 patients
Phase 4Unknown
NCT03743896T-TherapeuticsTransdermal Glucosamine Cream

Transdermal Delivery of Glucosamine to the Synovial Fluid of Male and Female With Knee Osteoarthritis

Start: May 2016Est. completion: Mar 2017
Phase 4Completed

Extract of Curcuma Longa Complexed With Phosphatidilcholine(Motore®)in the Treatment of Adults With Knee Osteoarthritis

Start: Jun 2015Est. completion: Jun 2016288 patients
Phase 4Completed

Efficacy Study of Intra-articular Hyaluronic Acid in the Knee Osteoarthritis

Start: Nov 2007Est. completion: May 2010381 patients
Phase 4Completed

Study Of "Continuous Use" Of Celecoxib Vs. "Usual or Intermittent Use"

Start: Jul 2005Est. completion: Feb 2008875 patients
Phase 4Completed

Safety and Efficacy of Celecoxib Versus Naproxen in the 6-month Treatment of Knee Osteoarthritis

Start: Mar 2004Est. completion: Jan 2005586 patients
Phase 4Completed

Efficacy and Safety of Celecoxib Versus Ibuprofen in the Treatment of Osteoarthritis of the Knee (Europe)

Start: Jan 2003Est. completion: Feb 2004388 patients
Phase 4Completed

Efficacy and Safety of Celecoxib Versus Ibuprofen in the Treatment of Osteoarthritis of the Knee (United States)

Start: Oct 2002Est. completion: Mar 2003393 patients
Phase 4Completed
NCT06917404Paradigm TherapeuticsPentosan Polysulfate Sodium twice weekly

A Study to Investigate the Treatment Effect of Subcutaneous Injections of Pentosan Polysulfate Sodium Compared With Placebo in Adult Participants With Knee Osteoarthritis Pain.

Start: May 2025Est. completion: Jul 2027466 patients
Phase 3Recruiting
NCT05362851Yooyoung PharmaceuticalYYC301-1 & YYC301-2 & YYC301-3

Clinical Trial of YYC301 P3 for Treatment of Osteoarthritis of the Knee

Start: Nov 2021Est. completion: Mar 2023692 patients
Phase 3Unknown

Study to Evaluate Resiniferatoxin in Patients With Knee Osteoarthritis Whose Total Knee Replacement Surgery is Delayed

Start: Apr 2021Est. completion: Jun 20220
Phase 3Withdrawn

A Phase 3 Study to Evaluate the Efficacy and Safety of Resiniferatoxin for Pain Due to Osteoarthritis of the Knee

Start: Dec 2020Est. completion: Mar 20230
Phase 3Withdrawn
NCT04440189GID BioGID SVF-2 Device System

Autologous Adipose-derived Stromal Vascular Fraction for Treatment of Knee Osteoarthritis

Start: Oct 2020Est. completion: Jun 2025114 patients
Phase 3Active Not Recruiting

Study of Cingal® and Triamcinolone Hexacetonide for the Relief of Knee Osteoarthritis Pain

Start: Sep 2020Est. completion: May 2022231 patients
Phase 3Completed

A RCT Comparing Dronabinol to a Placebo for Post-operative Pain in Total Joint Arthroplasty

Start: Feb 2020Est. completion: Feb 2025460 patients
Phase 3Unknown

Clinical Trial of YYD302 (Phase3) for Treatment of Osteoarthritis of the Knee

Start: Feb 2018Est. completion: Oct 2019184 patients
Phase 3Completed

A Phase 3 Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain

Start: Jan 2018Est. completion: Nov 2019332 patients
Phase 3Completed

Efficacy and Safety of Topical Application of Tranexamic Acid for Saving Blood Losses in Patients Subjected to Prosthetic Knee Surgery

Start: Nov 2017Est. completion: May 2019150 patients
Phase 3Completed

Evaluate the Efficacy and Safety of Fasinumab in Patients With Moderate-to-Severe Chronic Low Back Pain and Osteoarthritis of the Hip or Knee

Start: Oct 2017Est. completion: May 201963 patients
Phase 3Terminated

Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Nonsteroidal Anti-inflammatory Drugs (NSAIDs) for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip

Start: Oct 2017Est. completion: Nov 20201,650 patients
Phase 3Completed

A Study to Determine the Safety and the Efficacy of Fasinumab Compared to Placebo and Naproxen for Treatment of Adults With Pain From Osteoarthritis of the Knee or Hip

Start: Aug 2017Est. completion: Aug 20213,307 patients
Phase 3Completed

A Study to Assess the Efficacy and Safety of AXS-02 in Subjects With Knee OA Associated With Bone Marrow Lesions

Start: Mar 2016Est. completion: Dec 2020346 patients
Phase 3Unknown

CREATE-1: A Study to Assess the Efficacy and Safety of AXS-02 in Patients With CRPS-1

Start: Jul 2015Est. completion: Jan 2019190 patients
Phase 3Unknown

Evaluation of GW406381 in Treating Adults With Osteoarthritis Of The Knee

Start: May 2005Est. completion: Sep 20071,340 patients
Phase 3Completed
NCT04809376Paradigm TherapeuticsPentosan Polysulfate Sodium twice weekly

Treatment Effects of Subcutaneous Injections of Pentosan Polysulfate Sodium vs Placebo in Participants With Knee OA Pain

Start: Oct 2021Est. completion: Jan 2025602 patients
Phase 2/3Active Not Recruiting

Study of REGN475 in Patients With Pain Due to Osteoarthritis of the Knee or Hip

Start: May 2015Est. completion: Nov 2016421 patients
Phase 2/3Completed

PPV-06 Vaccine in Inflammatory Knee Osteoarthritis

Start: Dec 2025Est. completion: Dec 2028204 patients
Phase 2Not Yet Recruiting

Study to Evaluate Intra-articular Resiniferatoxin to Treat Moderate to Severe Pain From Knee Osteoarthritis

Start: Nov 2021Est. completion: Nov 2023124 patients
Phase 2Unknown
NCT05027581A2 Biotherapeuticsbone marrow mesenchymal stem cells

Chondrochymal® for Subjects With Knee Osteoarthritis (Knee OA)

Start: Oct 2021Est. completion: Jun 202572 patients
Phase 2Completed

Efficacy and Safety Trial of PTP-001 (MOTYS) for Symptomatic Knee Osteoarthritis

Start: Sep 2021Est. completion: Nov 2022210 patients
Phase 2Active Not Recruiting
NCT05016011CytopeuticsHuman umbilical cord-derived mesenchymal stem cells

Efficacy of Allogeneic UCMSCs for Treating Large Defects Knee Injury

Start: Jul 2020Est. completion: Mar 202228 patients
Phase 2Completed

Efficacy and Safety of XT-150 in Osteoarthritis of the Knee

Start: Feb 2020Est. completion: Apr 2022289 patients
Phase 2Completed

Saline Injections vs Education and Exercise in Knee Osteoarthritis

Start: Aug 2019Est. completion: Dec 2020206 patients
Phase 2Completed

Study to Evaluate Arthroplasty Specimens for Osteoarthritis of the Knee and Hip

Start: Apr 2019Est. completion: Aug 202023 patients
Phase 2Terminated

Safety & Efficacy FloGraft (Micronized Human Amnion Chorion Membrane)® in Adults With Pain Due to OA of the Knee

Start: Nov 2018Est. completion: Mar 2019320 patients
Phase 2Unknown

Study to Evaluate the Effects of Fasinumab on Peripheral Nerve Function in Patients With Pain Due to Osteoarthritis of the Hip or Knee

Start: Oct 2018Est. completion: Jan 2021180 patients
Phase 2Completed

Clinical Trial of YYC301 for Treatment of Osteoarthritis of the Knee

Start: Aug 2018Est. completion: Sep 2020261 patients
Phase 2Completed

A Phase 2 Clinical Trial Examining the Effects on Osteoarthritic Knee Pain of CGS-200-1, CGS-200-5 and Vehicle Control

Start: May 2018Est. completion: Dec 2018122 patients
Phase 2Completed

SI-613 Study for Knee Osteoarthritis

Start: Oct 2017Est. completion: Nov 201880 patients
Phase 2Completed

A Study to Evaluate ONO-4474 in Patients With Pain Due to Osteoarthritis of the Knee

Start: Jan 2017Est. completion: Jan 201870 patients
Phase 2Terminated

A Study to Evaluate Safety and Tolerability of MIV-711 in Osteoarthritis Patients

Start: Sep 2016Est. completion: Nov 201750 patients
Phase 2Completed

A Study to Evaluate the Efficacy, Safety and Tolerability of MIV-711 in Osteoarthritis Patients

Start: Jan 2016Est. completion: May 2017244 patients
Phase 2Completed
NCT02471118AbbVieAdalimumab 40 mg

Osteoarthritis of the Knee, Inflammation, and the Effect of Adalimumab (OKINADA)

Start: Mar 2015Est. completion: Mar 202162 patients
Phase 2Completed

Study to Evaluate the Efficacy and Safety of Intra-articular DA-5202 in Patients With Osteoarthritis of the Knee

Start: Dec 2014Est. completion: Oct 2016115 patients
Phase 2Completed

A Study of LY2951742 in Participants With Mild to Moderate Osteoarthritis Knee Pain

Start: Jul 2014Est. completion: Jun 2015268 patients
Phase 2Terminated

A Study to Investigate the Safety and Effectiveness of Different Doses of Sprifermin in Participants With Osteoarthritis of the Knee

Start: Jul 2013Est. completion: May 2019549 patients
Phase 2Completed
NCT01688934Purdue PharmaV116517 50-mg tablets

Analgesic Efficacy and Safety of V116517 in Subjects With Moderate to Severe Chronic Pain Due to Osteoarthritis (OA) of the Knee

Start: Sep 2012Est. completion: Aug 2013230 patients
Phase 2Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

17 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 17,528 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.