Infertility

63
Pipeline Programs
15
Companies
50
Clinical Trials
2 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
13
1
25
21
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Ferring Pharmaceuticals
MENOPURApproved
menotropins
Ferring Pharmaceuticals
subcutaneous2004

Competitive Landscape

15 companies ranked by most advanced pipeline stage

Ferring Pharmaceuticals
Ferring PharmaceuticalsArgentina - Buenos Aires
42 programs
2
6
1
11
7
BravellePhase 41 trial
EndometrinPhase 41 trial
Endometrin® plus Progesterone in OilPhase 41 trial
MenotrophinPhase 41 trial
MenotrophinPhase 41 trial
+37 more programs
Active Trials
NCT06280677Recruiting160Est. Sep 2026
NCT02032264Completed309Est. Jan 2017
NCT00963625Completed100Est. Oct 2010
+39 more trials
M&
Merck & Co.RAHWAY, NJ
29 programs
5
5
10
10000 IU urinary HCGPhase 41 trial
CrinonePhase 41 trial
Double StimulationPhase 41 trial
FSHPhase 41 trial
ForiellePhase 41 trial
+24 more programs
Active Trials
NCT04710264CompletedEst. Sep 2025
NCT01318291Completed166Est. Sep 2014
NCT01109654Completed2,175Est. Dec 2010
+34 more trials
IBSA Institut Biochimique
IBSA Institut BiochimiqueSwitzerland - Lugano-Pazzallo
12 programs
1
1
7
1
UrofollitrophinPhase 41 trial
FSH-IBSAPhase 31 trial
Follicle Stimulating HormonePhase 31 trial
MenotropinsPhase 31 trial
Progesterone-IBSA Injectable SolutionPhase 31 trial
+7 more programs
Active Trials
NCT01107470UnknownEst. Apr 2013
NCT03735030CompletedEst. Aug 2019
NCT03701490CompletedEst. Dec 2022
+8 more trials
Guerbet
GuerbetFrance - Villepinte
1 program
1
Lipiodol UFPhase 41 trial
Active Trials
NCT03604549Completed58Est. Aug 2021
COUR Pharmaceuticals
1 program
1
rFSH drug dosePhase 41 trial
Active Trials
NCT00374634CompletedEst. Oct 2008
Teva
TevaIsrael - Petach Tikva
2 programs
1
1
DR-2011Phase 31 trial
DR-2011Phase 21 trial
Active Trials
NCT00117468Completed20Est. Apr 2006
NCT00615251Completed1,297Est. Aug 2009
Qilu Pharmaceutical
Qilu PharmaceuticalChina - Jinan
1 program
1
QL1012Phase 31 trial
Active Trials
NCT05149924CompletedEst. Oct 2019
Progyny
ProgynyNY - New York
9 programs
Correlating Time-Lapse Parameters With aCGH Testing in IVF Treatment (aCGH Study)N/A1 trial
Eeva System StudyN/A1 trial
Eeva™ Continued Access Study: Assessing the Usability of Eeva in a Clinical SettingN/A1 trial
Eeva™ Pregnancy Investigational Clinical Study: A Postmarket Follow-Up StudyN/A1 trial
Eeva™ TestN/A1 trial
+4 more programs
Active Trials
NCT02141685Unknown50Est. Feb 2016
NCT01369446Completed160Est. Apr 2012
NCT01617993Completed31Est. Feb 2013
+6 more trials
Conception
ConceptionCA - Berkeley
2 programs
Lifestyle behaviour and dietary habits assessmentN/A1 trial
PIPELLE ENDOMETRIAL SAMPLINGN/A1 trial
Active Trials
NCT03050944CompletedEst. Dec 2016
NCT00796341CompletedEst. Sep 2008
Abbott
AbbottABBOTT PARK, IL
1 program
Duphaston®N/A1 trial
Active Trials
NCT04249297Unknown1,150Est. Dec 2022
Femasys
FemasysSUWANEE, GA
1 program
FemaSeed Localized Directional InseminationN/A1 trial
Active Trials
NCT04968847Completed314Est. Apr 2024
Alife
AlifeGEORGE TOWN, Cayman Islands
1 program
Hera ScoreN/A1 trial
Active Trials
NCT05483985Active Not Recruiting440Est. Jan 2025
Genomics
GenomicsUK - Oxford
1 program
Non-invasive chromosome screening(NICS)N/A1 trial
Active Trials
NCT04339166Completed1,152Est. Aug 2024
Genesis Therapeutics
Genesis TherapeuticsCA - Burlingame
1 program
Preimplantation Genetic Screening by NGSN/A1 trial
Active Trials
NCT02268786Completed661Est. Dec 2016
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
measuring cell freeDNAN/A1 trial
Active Trials
NCT02480491CompletedEst. May 2015

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Merck & Co.rhFSH+rhLH
Merck & Co.Double Stimulation
Merck & Co.Crinone
GuerbetLipiodol UF
Merck & Co.GERI+ incubator
Merck & Co.Forielle
Merck & Co.corifollitropin alfa
Ferring Pharmaceuticalsmenotropin
Merck & Co.corifollitropin alfa
Ferring PharmaceuticalsEndometrin® plus Progesterone in Oil
IBSA Institut BiochimiqueUrofollitrophin
Merck & Co.HCG
Merck & Co.FSH
Ferring PharmaceuticalsBravelle
Ferring PharmaceuticalsMenotrophin

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 12,385 patients across 50 trials

PErsonalized Addition of Recombinant LH in Ovarian Stimulation

Start: Feb 2021Est. completion: Nov 2025
Phase 4Recruiting
NCT04446845Merck & Co.Double Stimulation

Double Stimulation Followed by a Fresh Embryo Transfer

Start: Oct 2020Est. completion: May 2023120 patients
Phase 4Completed

Efficacy and Safety of Crinone Versus Combination Medication (ACCESS)

Start: May 2019Est. completion: Oct 2021172 patients
Phase 4Terminated

Sonographic Hysterosalpingography: Oil vs Water Based Media (SHOW Trial)

Start: Jan 2019Est. completion: Aug 202158 patients
Phase 4Completed
NCT03164551Merck & Co.GERI+ incubator

TICON-Day 3, Time Lapse Versus Conventional Method in Day 3 Embryo Culture and Assessment

Start: Apr 2018Est. completion: Nov 2019408 patients
Phase 4Terminated

Clinical Performance and Safety Investigation of ENDOmetrial Washing MEdical DEvice Forielle

Start: Jan 2018Est. completion: Jun 20189 patients
Phase 4Terminated
NCT02606500Merck & Co.corifollitropin alfa

Efficacy of Corifollitropin Alfa in Obese Women in Terms of Clinical and Molecular Parameters of IVF Success

Start: Mar 2016Est. completion: Mar 201770 patients
Phase 4Completed

MENOPUR® in a Gonadotropin-Releasing Hormone (GnRH) Antagonist Cycle With Single-Blastocyst Transfer in a High Responder Subject Population

Start: Aug 2015Est. completion: Feb 2017620 patients
Phase 4Completed
NCT02466204Merck & Co.corifollitropin alfa

Efficacy of Corifollitropin Alfa Versus Follitropin Beta in Aged IVF (In-vitro Fertilization) Patients

Start: Jun 2015Est. completion: Aug 2017400 patients
Phase 4Completed
NCT02254577Ferring PharmaceuticalsEndometrin® plus Progesterone in Oil

Vaginal Compared to Intramuscular Progesterone for Frozen Embryo Transfer

Start: Oct 2014Est. completion: Apr 20181,139 patients
Phase 4Completed

FSH in GnRH-AntagoniST Controlled Ovarian Hyperstimulation Cycles (FAST)

Start: Jan 2014Est. completion: Aug 2017
Phase 4Completed

Study of Dual Trigger Ovulation in Oocyte Donors

Start: Jan 2013Est. completion: Jun 201626 patients
Phase 4Terminated

Anti-Mullerian Hormone (AMH) Versus Antral Follicle Count (AFC) Guided rFSH Dosing Study

Start: Oct 2011Est. completion: Dec 2012348 patients
Phase 4Completed

Menopur Mixed Protocol

Start: Jul 2011Est. completion: Jan 2012122 patients
Phase 4Completed

Progesterone Serum Levels in Subfertile Female Patients Undergoing in Vitro Fertilisation (IVF)

Start: Oct 2010Est. completion: Jun 2013124 patients
Phase 4Completed

Vaginal Progesterone Versus Progesterone in Oil in Donor Egg Recipient In Vitro Fertilization Cycles Utilizing Vitrified Donor Eggs

Start: Feb 2010Est. completion: Sep 201110 patients
Phase 4Completed

MENOPUR® Versus FOLLISTIM®

Start: Dec 2008Est. completion: Jan 2010173 patients
Phase 4Completed
NCT00829244Merck & Co.GONAL f® prefilled pen

CONSORT Randomized Controlled Trial in Assisted Reproductive Technology

Start: Aug 2008Est. completion: Jan 2010
Phase 4Completed

Individual Versus Standard Follicle Stimulating Hormone Dose for Controlled Ovarian Stimulation and Insemination

Start: Sep 2006Est. completion: Oct 2008
Phase 4Completed

A Study of the Efficacy and Safety of Highly Purified Menotrophin Versus Recombinant Follitropin Alfa

Start: Oct 2005Est. completion: Apr 200980 patients
Phase 4Completed
NCT00953628Merck & Co.10000 IU urinary HCG

Endometrial Advancement After Rec or u-HCG Triggering

Start: Aug 2005Est. completion: Dec 2008
Phase 4Completed
NCT07340827Merck & Co.Follitropin alfa/lutropin alfa

A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH and FSH Deficiency Undergoing ART (HINATA)

Start: Feb 2026Est. completion: Jun 2029333 patients
Phase 3Recruiting
NCT04549116IBSA Institut BiochimiqueProgesterone-IBSA Injectable Solution

Subcutaneous Progesterone in Frozen- Thawed Single Euploid Blastocyst Transfer.

Start: Oct 2022Est. completion: Jun 2026
Phase 3Active Not Recruiting

A Trial to Compare the Ovarian Response of REKOVELLE and GONAL-F in Conventional Dosing in Women Undergoing Controlled Ovarian Stimulation

Start: Jul 2022Est. completion: Apr 2024302 patients
Phase 3Completed

Efficacy and Safety of FE 999049 in Controlled Ovarian Stimulation in Indian Women

Start: Dec 2021Est. completion: Dec 2023220 patients
Phase 3Completed
NCT03895099Merck & Co.Desogestrel early follicular phase

New Ovarian Stimulation With Random Start, Use of Progestin Protocol for Oocyte Donors

Start: Sep 2020Est. completion: Oct 2023110 patients
Phase 3Completed
NCT04163458Ferring PharmaceuticalsMENOPUR solution for injection in pre-filled pen, 1200 IU/1.92 mL

Comparison of MENOPUR Liquid and Powder in Women Undergoing Assisted Reproductive Technology (ART)

Start: Oct 2019Est. completion: Jul 2021405 patients
Phase 3Completed

Efficacy and Safety of QL1012 in Women for Assisted Reproductive Treatment

Start: Oct 2018Est. completion: Oct 2019
Phase 3Completed

Recombinant FSH Investigation in the Treatment of Infertility With Assisted Reproductive Technology (ART) (RITA-1)

Start: Oct 2018Est. completion: Nov 2020579 patients
Phase 3Completed
NCT03197077Merck & Co.corifollitropin alfa

Optimisation of Follicular Recruitment in IVM Cycles

Start: Nov 2017Est. completion: Dec 2022145 patients
Phase 3Completed

Efficacy and Safety of FE 999049 in Controlled Ovarian Stimulation in Japanese Women

Start: Jul 2017Est. completion: Jul 2019373 patients
Phase 3Completed
NCT02884245Merck & Co.corifollitropin alfa

Interest of Estrogen Scheduling Before Ovarian Stimulation With Corifollitropin Alfa

Start: Nov 2016Est. completion: Jan 2023334 patients
Phase 3Completed
NCT02449889Ferring Pharmaceuticalshighly purified human chorionic gonadotropin

A Randomised Trial Using Highly Purified Human Chorionic Gonadotropin (HP-hCG) and Recombinant Human Chorionic Gonadotropin (rhCG) in Women Undergoing Controlled Ovarian Stimulation

Start: Apr 2016Est. completion: Mar 2018176 patients
Phase 3Completed
NCT02310919Ferring PharmaceuticalsLow dose hCG plus FSH co-trigger

Administration of Follicle-stimulating Hormone (FSH) and Low Dose Human Chorionic Gonadotropin (hCG) for Oocyte Maturity While Decreasing hCG Exposure in In Vitro Fertilization (IVF) Cycles

Start: Sep 2014Est. completion: Jun 2018105 patients
Phase 3Completed

Evidence-based Stimulation Trial With Human rFSH in Europe and Rest of World 2

Start: Mar 2014Est. completion: Jan 2017513 patients
Phase 3Completed

Phase 3 Study to Evaluate the Efficacy and Safety of Pergoveris® in Assisted Reproductive Technology (ESPART)

Start: Jan 2014Est. completion: Aug 2015939 patients
Phase 3Completed
NCT01922193Ferring PharmaceuticalsHighly Purified Urofollitropin

Evaluation of Efficacy and Safety of Highly Purified Urofollitropin in Chinese Females Undergoing an Assisted Reproductive Technology (ART) Program

Start: Oct 2013Est. completion: Apr 2015263 patients
Phase 3Completed

Evidence-based Stimulation Trial With Human rFSH in Europe and Rest of World 1

Start: Oct 2013Est. completion: Jan 20171,329 patients
Phase 3Completed

PERgoveriS In Stratified Treatment for Assisted Reproductive Technique

Start: May 2011Est. completion: Oct 2012202 patients
Phase 3Completed

Safety and Efficacy Study in in Vitro Fertilisation (IVF) Patients

Start: Feb 2011Est. completion: Dec 2013
Phase 3Completed
NCT00884221Ferring PharmaceuticalsHighly purified menotrophin

MENOPUR in Gonadotrophin-releasing Hormone (GnRH) Antagonist Cycles With Single Embryo Transfer

Start: Jul 2009Est. completion: Jan 2011749 patients
Phase 3Completed

A Clinical Trial to Evaluate the Efficacy and Safety of DR-2011 for In Vitro Fertilization

Start: Feb 2008Est. completion: Aug 20091,297 patients
Phase 3Completed

Clinical Tolerance and Equivalence of hCG-IBSA vs Recombinant Human Chorionic Gonadotrophin in Women Undergoing In Vitro Fertilisation

Start: Aug 2005Est. completion: Dec 2008
Phase 3Completed

Clinical Study of Clinical Efficacy and Tolerability of hMG-IBSA s.c.in Women Undergoing COH in an ART Programme (IVF).

Start: May 2005Est. completion: Mar 2009
Phase 3Completed

Clinical Efficacy and Tolerability of Two FSH Preparations (Human FSH Versus rFSH - Follitropin Alpha) in Women Undergoing IVF

Start: Mar 2005Est. completion: May 2006
Phase 3Completed
NCT01081652Merck & Co.Micronised Progesterone

A Study Using Micronised Progesterone (Crinone® 8%) in the Luteal Phase Support of Women Undergoing in Vitro Fertilisation (IVF) and Embryo Transfer (ET)

Start: May 2004Est. completion: May 2005
Phase 3Completed
NCT01081639Merck & Co.Follitropin alfa liquid formulation

To Evaluate the Convenience, Safety and Efficacy of Follitropin Alfa Liquid Pen Compared With Follitropin Beta Liquid Pen

Start: Nov 2003Est. completion: Sep 2004
Phase 3Completed
NCT00335725IBSA Institut BiochimiqueFollicle Stimulating Hormone

Efficacy and Tolerability of Human FSH Versus Recombinant FSH (Follitropin Alpha) in ICSI.

Start: Mar 2003Est. completion: Dec 2005
Phase 3Completed

Prospective, Randomized, Controlled, Clinical Study on Tolerability and Efficacy of hMG-IBSA

Start: Dec 2001Est. completion: Apr 2005
Phase 3Completed
NCT00296465Ferring PharmaceuticalsPulsatile gonadotropin-releasing hormone

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Three Dosage Strengths of Pulsatile GnRH

Start: Feb 2005Est. completion: Nov 2005132 patients
Phase 2/3Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

25 late-stage (Phase 3) programs — potential near-term approvals
2 actively recruiting trials targeting 12,385 patients
15 companies competing in this space