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Human Immunodeficiency Virus

49
Pipeline Programs
20
Companies
50
Clinical Trials
3 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
15
0
13
0
5
16
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
14100%
+ 97 programs with unclassified modality

On Market (1)

Approved therapies currently available

GSK
SELZENTRYApproved
maraviroc
GSK
CCR5 Co-receptor Antagonist [EPC]oral2016
9M Part D

Competitive Landscape

20 companies ranked by most advanced pipeline stage

MSD
MSDIreland - Ballydine
12 programs
5
2
1
3
3-drug anti-HIV therapyPhase 41 trial
EBR/GZRPhase 41 trial
emtricitabine/tenofovir disoproxil fumaratePhase 41 trial
Comparator: raltegravirPhase 3Small Molecule1 trial
IslatravirPhase 2Small Molecule1 trial
+7 more programs
Active Trials
NCT02218320Completed20Est. Oct 2015
NCT03894124Completed24Est. Aug 2019
NCT03615183Completed17Est. Sep 2019
+9 more trials
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
12 programs
5
2
1
3
3-drug anti-HIV therapyPhase 4
EBR/GZRPhase 4
emtricitabine/tenofovir disoproxil fumaratePhase 4
Comparator: raltegravirPhase 3Small Molecule
IslatravirPhase 2Small Molecule
+7 more programs
ViiV Healthcare
ViiV HealthcareNC - Durham
10 programs
3
5
Clinically Driven MonitoringPhase 4
Dolutegravir/LamivudinePhase 4
MaravirocPhase 4
dolutegravir 50 mgPhase 4
dolutegravir/abacavir/lamivudinePhase 4
+5 more programs
GSK
GSKLONDON, United Kingdom
9 programs
1
Cabotegravir Injectable ProductN/A1 trial
Maraviroc along with an optimized background antiretroviral drug regimenN/A1 trial
MaravirocPHASE_21 trial
Raltegravir-MaravirocPHASE_2
Clinically Driven MonitoringPHASE_41 trial
+4 more programs
Active Trials
NCT06518408Active Not Recruiting287Est. Sep 2027
NCT00665561Completed2,500Est. Feb 2019
NCT00791700Unknown103Est. Jun 2023
+5 more trials
Kite Pharma
Kite PharmaCA - El Segundo
6 programs
2
3
BIKTARVY 50Mg-200Mg-25Mg TabletPhase 4
Single Dose ElivitegravirPhase 4Small Molecule
bictegravir/emtricitabine/tenofovir alafenamidePhase 4
BiktarvyPhase 3
E/C/F/TAF;Phase 3
+1 more programs
AbbVie
AbbVieNORTH CHICAGO, IL
3 programs
1
lopinavir/ritonavirPhase 4Small Molecule
Kaletra in Combination With Antiretroviral AgentsN/A
Kaletra: Therapy With Double Protease InhibitorsN/A
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
5 programs
1
VareniclinePhase 31 trial
Collaborative Care ModelN/A1 trial
Impact of ART Adherence on HIV Persistence and InflammationN/A1 trial
In-Person Program Management PlusN/A1 trial
cMMN/A1 trial
Active Trials
NCT06117163Recruiting900Est. May 2028
NCT02797093Completed71Est. Oct 2018
NCT05841797Completed120Est. Aug 2025
+2 more trials
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
12 programs
4
1
AspirinPhase 22 trials
3BNC117-LSPhase 11 trial
3BNC117-LSPhase 11 trial
LenacapavirPhase 1Small Molecule1 trial
TLC-ARTPhase 11 trial
+7 more programs
Active Trials
NCT06604663Enrolling By Invitation80,000Est. Oct 2026
NCT03512964Completed32Est. Sep 2020
NCT01460433Completed21Est. Jan 2013
+9 more trials
Human BioSciences
Human BioSciencesWV - Martinsburg
10 programs
1
Peer support and mentoringPhase 21 trial
A couples-focused intervention for HIV prevention and care in South AfricaN/A1 trial
Men-Centered HIV TestingN/A1 trial
Oraquick HIV Self TestN/A1 trial
Oraquick HIV Self Test - ChoiceN/A1 trial
+5 more programs
Active Trials
NCT05231707Active Not Recruiting544Est. May 2026
NCT03794245Completed1,806Est. Apr 2022
NCT03162965Completed898Est. Oct 2018
+6 more trials
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
4 programs
1
Peer support and mentoringPhase 2
AntiretroviralsN/A1 trial
Men-Centered HIV TestingN/A
flexible sigmoidoscopy or colonoscopy with biopsiesN/A1 trial
Active Trials
NCT03205696Completed101Est. Nov 2023
NCT02134431Completed13Est. Jun 2015
Pfizer
PfizerNEW YORK, NY
4 programs
3
CP-675,206Phase 22 trials
CapravirinePhase 21 trial
MaravirocPhase 2
Maraviroc along with an optimized background antiretroviral drug regimenN/A
Active Trials
NCT01008358Completed20Est. May 2012
NCT00488995Withdrawn0
NCT00051844Completed179Est. Nov 2004
TaiMed Biologics
TaiMed BiologicsTaiwan - Taipei
1 program
1
TMB-607Phase 11 trial
Active Trials
NCT03110549Terminated9Est. Jul 2019
Gilead Sciences
Gilead SciencesFOSTER CITY, CA
8 programs
Point-of-CareN/A1 trial
Point-of-CareN/A
BiktarvyPHASE_32 trials
E/C/F/TAF;PHASE_31 trial
E/C/F/TAF;PHASE_3
+3 more programs
Active Trials
NCT04560556Completed122Est. Nov 2021
NCT04653194Completed36Est. Jul 2023
NCT04519970Completed100Est. Apr 2024
+4 more trials
Merck & Co.
Merck & Co.RAHWAY, NJ
5 programs
RaltegravirN/ASmall Molecule
MK-8527PHASE_1
MK-8527PHASE_1
EBR/GZRPHASE_4
emtricitabine/tenofovir disoproxil fumaratePHASE_4
Impact Therapeutics
Impact TherapeuticsChina - Shanghai
4 programs
Provision of multiple self-testsN/A1 trial
Provision of multiple self-testsN/A1 trial
Provision of multiple self-testsN/A1 trial
Receives mobile banking account with incentives to saveN/A
Active Trials
NCT04772469Completed934Est. Apr 2023
NCT03135067Completed2,102Est. Mar 2020
NCT04805112Completed349Est. Jul 2021
Abbott
AbbottABBOTT PARK, IL
2 programs
Kaletra in Combination With Antiretroviral AgentsN/A1 trial
Kaletra: Therapy With Double Protease InhibitorsN/A1 trial
Active Trials
NCT01076179Completed502Est. Jan 2016
NCT01075191Completed65Est. Sep 2011
Allied Medical
Allied MedicalMO - St. Louis
1 program
Blood glucose and blood pressure testingN/A1 trial
Active Trials
NCT03098654Completed214Est. Aug 2022
Integrated Biosciences
Integrated BiosciencesCA - San Carlos
1 program
Community home-based care interventionN/A1 trial
Active Trials
NCT03505866Completed720Est. Aug 2015
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
Integrated e-healthcare servicesN/A1 trial
Active Trials
NCT04179344CompletedEst. Oct 2019
Genentech
GenentechCA - Oceanside
1 program
pegylated interferon-alphaN/A1 trial
Active Trials
NCT00909129Completed25

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Gilead SciencesBIKTARVY 50Mg-200Mg-25Mg Tablet
GSKDolutegravir/Lamivudine
Gilead Sciencesbictegravir/emtricitabine/tenofovir alafenamide
MSDEBR/GZR
GSKdolutegravir/abacavir/lamivudine
GSKdolutegravir 50 mg
Gilead SciencesSingle Dose Elivitegravir
GSKMaraviroc
MSDemtricitabine/tenofovir disoproxil fumarate
MSD3-drug anti-HIV therapy
GSKClinically Driven Monitoring
Colorado TherapeuticsVarenicline
Gilead SciencesBiktarvy
Gilead SciencesE/C/F/TAF;
MSDComparator: raltegravir

Showing 15 of 49 trials with date data

Clinical Trials (50)

Total enrollment: 89,386 patients across 50 trials

NCT04944654Gilead SciencesBIKTARVY 50Mg-200Mg-25Mg Tablet

Efficacy, Tolerability and Acceptability of Biktarvy by TPLWH

Start: Jan 2023Est. completion: May 20231 patients
Phase 4Terminated
NCT04826562GSKDolutegravir/Lamivudine

Switch to DOVATO in Patients Suppressed on Biktarvy (SOUND)

Start: Sep 2021Est. completion: Dec 202340 patients
Phase 4Unknown
NCT03502005Gilead Sciencesbictegravir/emtricitabine/tenofovir alafenamide

Efficacy, Safety & Tolerability of Switching EFV/TDF/FTC to BIC/FTC/TAF in Virologically Suppressed Adults With HIV-1

Start: Mar 2018Est. completion: Dec 2019100 patients
Phase 4Completed

Impact of Hepatitis C Therapy and Bone Health

Start: Aug 2017Est. completion: Nov 20186 patients
Phase 4Terminated
NCT02659761GSKdolutegravir/abacavir/lamivudine

Triumeq As an Integrase Single Tablet Regimen in People With HIV Who Inject Drugs

Start: Nov 2016Est. completion: Sep 202133 patients
Phase 4Terminated
NCT02211690GSKdolutegravir 50 mg

The Tolerability of, and Adherence to, Dolutegravir With Co-formulated Tenofovir-emtricitabine for HIV Non-occupational Post-exposure Prophylaxis

Start: Aug 2014Est. completion: Feb 2016100 patients
Phase 4Completed
NCT01855867Gilead SciencesSingle Dose Elivitegravir

HIV Non-Occupational Post-Exposure Prophylaxis

Start: May 2013Est. completion: Apr 2016100 patients
Phase 4Completed

Switching Undetectables to Selzentry

Start: Jan 2013Est. completion: Jun 201431 patients
Phase 4Completed
NCT01234116MSDemtricitabine/tenofovir disoproxil fumarate

Post-Exposure Prophylaxis in Health Care Workers

Start: Feb 2011Est. completion: May 201316 patients
Phase 4Completed
NCT00781287MSD3-drug anti-HIV therapy

Raltegravir (Isentress/MK-0518) and HIV-1 Infected CD4 Cells During Acute/Early HIV-1

Start: Feb 2009Est. completion: Oct 201310 patients
Phase 4Terminated
NCT02028676GSKClinically Driven Monitoring

Efficacy Study of Different Laboratory Management Strategies and Drug Regimens in HIV-infected Children in Africa

Start: Mar 2007Est. completion: Jun 20121,206 patients
Phase 4Completed

V+PSF-M for Tobacco Cessation in HIV Care in India

Start: Jan 2024Est. completion: Jul 2026400 patients
Phase 3Recruiting

Efficacy of BIC/F/TAF Versus Standard of Care in the Treatment of New HIV Infection Diagnoses in the Context of 'Test and Treat'

Start: Sep 2020Est. completion: Jul 202336 patients
Phase 3Completed

HIV Drug Switch Followed by HCV Therapy in HIV-HCV Co-Infection

Start: Apr 2016Est. completion: Jun 201825 patients
Phase 3Completed
NCT00764946MSDComparator: raltegravir

A Study of Raltegravir in a Diverse Cohort of HIV-Infected Patients (0518-055)

Start: Oct 2008Est. completion: Feb 2011209 patients
Phase 3Completed
NCT05115838MSDIslatravir

Radiopaque Matrix MK-8591 Implant in Participants at Low-Risk for Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591-043)

Start: Jan 2024Est. completion: Oct 20250
Phase 2Withdrawn

Mechanisms of Benefit of IL4RA Inhibition in Aspirin-Exacerbated Respiratory Disease

Start: Aug 2023Est. completion: Apr 202617 patients
Phase 2Active Not Recruiting

Elite Controller and ART-treated HIV+ Statin Versus ASA Treatment Intervention Study

Start: Apr 2014Est. completion: Oct 201953 patients
Phase 2Completed
NCT01420523MSDRaltegravir-Maraviroc

Evaluation of Raltegravir Plus Maraviroc Therapy in Controlled HIV Patients Presenting With Lipohypertrophy

Start: Dec 2011Est. completion: Apr 201348 patients
Phase 2Terminated

An Open Label Pharmacokinetic, Safety And Efficacy Study Of Maraviroc In Combination With Background Therapy For The Treatment Of HIV-1 Infected, CCR5 -Tropic Children

Start: Apr 2009Est. completion: Jun 2023103 patients
Phase 2Unknown

Anti-CTLA-4 Human Monoclonal Antibody CP-675,206 in Patients With Advanced Hepatocellular Carcinoma

Start: Dec 2008Est. completion: May 201220 patients
Phase 2Completed
NCT00972699Human BioSciencesPeer support and mentoring

Mentor Mothers: A Sustainable Family Intervention in South African Townships

Start: Jul 2008Est. completion: Dec 20111,200 patients
Phase 2Completed

Safety And Efficacy Study Of CP-675,206 In HIV-Infected Patients

Start: Jul 20070
Phase 2Withdrawn

Capravirine (AG1549) in Combination With Viracept and Two NRTIs in HIV Infected Patients Who Failed an Initial NNRTI Containing Regimen

Start: Aug 2002Est. completion: Nov 2004179 patients
Phase 2Completed

Lenacapavir Intensification to Disrupt HIV Reservoirs in Virologically Suppressed People With HIV Receiving Antiretroviral Therapy

Start: Jan 2026Est. completion: Jan 202950 patients
Phase 1Recruiting

First in Human Study of TLC-ART 101 (ACTU 2001)

Start: Apr 2023Est. completion: Jun 202412 patients
Phase 1Completed

3BNC117-LS and 10-1074-LS Plus N-803 (bNAb+N-803)

Start: Dec 2022Est. completion: Dec 202528 patients
Phase 1Completed

MK-8527 Single-Dose Trial in HIV-1 Infected Participants (MK-8527-004)

Start: Nov 2022Est. completion: Jan 202420 patients
Phase 1Completed

3BNC117-LS and 10-1074-LS in Viremic HIV-infected Individuals

Start: Oct 2020Est. completion: Feb 20226 patients
Phase 1Completed
NCT03894124MSDDoravirine

Pharmacokinetics of Plasma Doravirine Once Daily Over 72 Hours Following Drug Intake Cessation in Healthy Volunteers

Start: Jun 2019Est. completion: Aug 201924 patients
Phase 1Completed

A Study of MK-8527 in Human Immunodeficiency Type 1 Virus (HIV-1) Infected Participants (MK-8527-002)

Start: Feb 2019Est. completion: Sep 201917 patients
Phase 1Completed

Study of the Safety, Tolerability and Pharmacokinetics of TMB-607 in HIV-Negative Volunteers

Start: Nov 2016Est. completion: Jul 20199 patients
Phase 1Terminated
NCT01289951MSDRaltegravir 400 mg/12hours

Pharmacokinetic Study of Raltegravir in Human Immunodeficiency Virus/Hepatitis C Virus (HIV/VHC) Coinfected Patients With Advanced (Child-Pugh C) Hepatic Cirrhosis

Start: Dec 2010Est. completion: Oct 201110 patients
Phase 1Completed
NCT01027182MSDRaltegravir

Comparison of Concentration-time Course of Plasma and Intracellular Raltegravir in Healthy Volunteers

Start: Dec 2009Est. completion: Mar 20106 patients
Phase 1Completed
NCT00909129Genentechpegylated interferon-alpha

Interactions of Hepatitis C Viral (HCV) Dynamics and Immune Activation in HIV Coinfected Patients During HCV Treatment

25 patients
N/ACompleted
NCT06117163Colorado TherapeuticsCollaborative Care Model

Integrated Mental Health Care for Pregnant Women With HIV in Kenya: The Tunawiri Study

Start: Oct 2024Est. completion: May 2028900 patients
N/ARecruiting
NCT06604663Allergy TherapeuticsActivation of the CDSS system

Data Science and Qualitative Research for Decision Support in the HIV Care Cascade

Start: May 2024Est. completion: Oct 202680,000 patients
N/AEnrolling By Invitation
NCT05841797Colorado TherapeuticsIn-Person Program Management Plus

Evaluation of Problem Management Plus in Pregnant Women With HIV in Kenya

Start: Jun 2023Est. completion: Aug 2025120 patients
N/ACompleted
NCT06518408GSKCabotegravir Injectable Product

A Real-life Study of the Use of Cabotegravir Plus Rilpivirine Long-acting in ART-experienced Pre-treated People With HIV

Start: Jun 2023Est. completion: Sep 2027287 patients
N/AActive Not Recruiting
NCT05385484Human BioSciencesReceives mobile banking account with incentives to save

A Savings Intervention to Reduce Men's Engagement in HIV Risk Behaviors

Start: Jul 2022Est. completion: Mar 20261,500 patients
N/AActive Not Recruiting
NCT05231707Human BioSciencesA couples-focused intervention for HIV prevention and care in South Africa

Simunye: A Couples-focused Intervention for HIV Prevention and Care in South Africa

Start: Apr 2022Est. completion: May 2026544 patients
N/AActive Not Recruiting

Pilot Test of a Couple-Based Medication Adherence Intervention for HIV-Positive Women and Their Male Partners in South Africa

Start: Nov 2021Est. completion: Dec 202240 patients
N/ACompleted
NCT04772469Impact TherapeuticsProvision of multiple self-tests

Self-Test Strategies and Linkage Incentives to Improve ART and PrEP Uptake in Men

Start: Mar 2021Est. completion: Apr 2023934 patients
N/ACompleted
NCT04805112Impact TherapeuticsProvision of multiple self-tests

Acceptability, Feasibility and Impact of Oral HIV Self-testing for Partner Testing Among Kenyan Adolescent Girls Aged 15-19 Years: A Randomized Controlled Trial

Start: Mar 2021Est. completion: Jul 2021349 patients
N/ACompleted

Linking Persons With HIV, Discharged From Jail, With Community Care

Start: Nov 2020Est. completion: Nov 2021122 patients
N/ACompleted

Clinical Opportunities and Management to Exploit Biktarvy as Asynchronous Connection Key (COMEBACK)

Start: Sep 2020Est. completion: Apr 2024100 patients
N/ACompleted
NCT04179344City TherapeuticsIntegrated e-healthcare services

Usability Study of IeHS in Indonesia

Start: Aug 2019Est. completion: Oct 2019
N/ACompleted

2-5 Intermittent Caloric Restriction in HIV

Start: May 2018Est. completion: Dec 202135 patients
N/ATerminated
NCT03098654Allied MedicalBlood glucose and blood pressure testing

Impact of Integrated HIV/NCD Screening on HIV Testing Uptake and Engagement in HIV Care in Kisarawe, Tanzania

Start: Feb 2018Est. completion: Aug 2022214 patients
N/ACompleted

Prevention and Treatment Continuum for Youth at HIV Risk, Acutely Infected and With Established HIV Infection

Start: Aug 2017Est. completion: Nov 2023101 patients
N/ACompleted

Related Jobs

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 late-stage (Phase 3) programs, potential near-term approvals
3 actively recruiting trials targeting 89,386 patients
20 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.