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Hematologic Malignancy

12
Pipeline Programs
22
Companies
22
Clinical Trials
4 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
7
2
2
0
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
375%
Cell Therapy
125%
+ 21 programs with unclassified modality

Competitive Landscape

20 companies ranked by most advanced pipeline stage

Sandoz
SandozAustria - Kundl
1 program
1
PelabresibPhase 31 trial
Active Trials
NCT06401356Recruiting50Est. Jun 2027
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
2 programs
1
1
Azacitidine in Combination With VenetoclaxPhase 21 trial
Fludarabine + Cyclophosphamide + CD7-specific CAR-T CellsPhase 1/2Cell Therapy1 trial
Active Trials
NCT06720324Recruiting80Est. Dec 2027
NCT04809181Unknown95Est. Mar 2026
Astellas
AstellasChina - Shenyang
1 program
1
IsavuconazolePhase 2Small Molecule1 trial
Active Trials
NCT03149055Completed99Est. Nov 2021
TargetRx
TargetRxChina - Shenzhen
1 program
1
TGRX-814Phase 1/21 trial
Active Trials
NCT06206174Recruiting30Est. Feb 2029
iCell Gene Therapeutics
iCell Gene TherapeuticsNY - Stony Brook
2 programs
2
CD123-CD33 cCAR T cellsPhase 1
CLL1-CD33 cCAR T cellsPhase 1
Biocorp
BiocorpFrance - Issoire
2 programs
2
CD123-CD33 cCAR T cellsPhase 11 trial
CLL1-CD33 cCAR T cellsPhase 11 trial
Active Trials
NCT04156256Unknown20Est. Sep 2020
NCT03795779Unknown20Est. Sep 2022
Kite Pharma
Kite PharmaCA - El Segundo
1 program
1
EntospletinibPhase 1Small Molecule1 trial
Active Trials
NCT03135028Terminated9Est. Feb 2019
Innovent Biologics
Innovent BiologicsChina - Jiangsu
1 program
1
IBI322Phase 11 trial
Active Trials
NCT04795128Completed70Est. Aug 2023
BioTherapeutics Inc
BioTherapeutics IncVA - Blacksburg
1 program
1
IvaltinostatPhase 1Small Molecule1 trial
Active Trials
NCT05716919Unknown32Est. Dec 2023
Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
2 programs
CPX-351PHASE_11 trial
FludarabinePHASE_21 trial
Active Trials
NCT03555955Completed21Est. May 2021
NCT02718755Withdrawn0Est. May 2022
Chia Tai TianQing Pharmaceutical Group
2 programs
TQB3702 tabletsPHASE_11 trial
TQB3909 tabletsPHASE_11 trial
Active Trials
NCT05610202Unknown137Est. Aug 2024
NCT06211751Not Yet Recruiting208Est. Jun 2026
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
BioStickerN/A1 trial
Active Trials
NCT05180838Completed20Est. Mar 2024
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
1 program
HM-PRON/A1 trial
Active Trials
NCT04757545Completed94Est. Feb 2023
CRISPR Therapeutics
1 program
Non InterventionalN/A1 trial
Active Trials
NCT06208878Enrolling By Invitation70Est. Aug 2038
Leuko
LeukoSpain - Madrid
1 program
PointCheckN/A1 trial
Active Trials
NCT04889937Completed46Est. Jul 2023
SPARK Biopharma
SPARK BiopharmaKorea - Seoul
1 program
TempTraqN/A1 trial
Active Trials
NCT06415656Completed32Est. Jul 2025
BioCity Biopharma
BioCity BiopharmaChina - Wuxi
1 program
BC3402 InjectionPHASE_11 trial
Active Trials
NCT05690425Unknown13Est. Jun 2024
Tr1X
Tr1XCA - San Diego
1 program
TRX103PHASE_11 trial
Active Trials
NCT06462365Recruiting36Est. Apr 2027
Mereo BioPharma
Mereo BioPharmaUK - London
1 program
MPH966PHASE_1_21 trial
Active Trials
NCT03986086Withdrawn0Est. Dec 2023
Novartis
NovartisBASEL, Switzerland
1 program
PelabresibPHASE_3

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
SandozPelabresib
UNION therapeuticsAzacitidine in Combination With Venetoclax
Jazz PharmaceuticalsFludarabine
AstellasIsavuconazole
UNION therapeuticsFludarabine + Cyclophosphamide + CD7-specific CAR-T Cells
TargetRxTGRX-814
Mereo BioPharmaMPH966
Tr1XTRX103
Chia Tai TianQing Pharmaceutical GroupTQB3909 tablets
BioCity BiopharmaBC3402 Injection
BioTherapeutics IncIvaltinostat
Chia Tai TianQing Pharmaceutical GroupTQB3702 tablets
Innovent BiologicsIBI322
Jazz PharmaceuticalsCPX-351
BiocorpCD123-CD33 cCAR T cells

Showing 15 of 22 trials with date data

Clinical Trials (22)

Total enrollment: 1,182 patients across 22 trials

An Extension Study for Patients Previously Enrolled in Studies With Pelabresib

Start: Aug 2024Est. completion: Jun 202750 patients
Phase 3Recruiting
NCT04809181UNION therapeuticsAzacitidine in Combination With Venetoclax

Azacitidine in Combination With Venetoclax Treatment for MRD Positive Post Allo-HSCT AML/MDS Patients

Start: Mar 2021Est. completion: Mar 202695 patients
Phase 2Unknown

Phase II Study of Fludarabine, Cytarabine (ARA-C) and Erwinase IV in Patients With Relapsed or Refractory Hematologic Malignancies

Start: May 2018Est. completion: May 20220
Phase 2Withdrawn
NCT03149055AstellasIsavuconazole

Fungal Prophylaxis With Isavuconazole for Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant (HCT)

Start: May 2017Est. completion: Nov 202199 patients
Phase 2Completed
NCT06720324UNION therapeuticsFludarabine + Cyclophosphamide + CD7-specific CAR-T Cells

CD7-specific CAR-T Cell in the Treatment of CD7-positive Relapsed/Refractory Hematologic Tumors

Start: Dec 2024Est. completion: Dec 202780 patients
Phase 1/2Recruiting

TGRX-814 Chinese Phase I/II in Patients With Hematological Malignancies

Start: Mar 2024Est. completion: Feb 202930 patients
Phase 1/2Recruiting

MPH966 for Prevention of Graft-versus-host Disease After Allogeneic Hematopoietic Stem Cell Transplantation

Start: Sep 2021Est. completion: Dec 20230
Phase 1/2Withdrawn

Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT)

Start: Apr 2024Est. completion: Apr 202736 patients
Phase 1Recruiting

A Clinical Trial of TQB3909 Tablets Combined With TQB3702 Tablets in Patients With Hematologic Malignancy

Start: Jan 2024Est. completion: Jun 2026208 patients
Phase 1Not Yet Recruiting

A Phase I Study of BC3402 as a Single Agent in Patients With MDS and CMML

Start: Jul 2023Est. completion: Jun 202413 patients
Phase 1Unknown

Multiple Ascending Dose Study of CG200745 'Ivaltinostat' Oral Capsule

Start: Mar 2023Est. completion: Dec 202332 patients
Phase 1Unknown

Tolerability and Pharmacokinetics Study of TQB3702 Tablets in Hematologic Tumor Subjects

Start: Nov 2022Est. completion: Aug 2024137 patients
Phase 1Unknown

A Study Evaluating the Safety, Tolerability and Preliminary Efficacy of IBI322 in Subjects With Hematologic Malignancy

Start: May 2021Est. completion: Aug 202370 patients
Phase 1Completed

A Trial to Evaluate the Potential Impact of Renal Impairment on the Pharmacokinetics and Safety of CPX-351

Start: Nov 2018Est. completion: May 202121 patients
Phase 1Completed
NCT04156256BiocorpCD123-CD33 cCAR T cells

CD123-CD33 cCAR in Patients With Relapsed and/or Refractory, High Risk Hematologic Malignancies

Start: Mar 2018Est. completion: Sep 202020 patients
Phase 1Unknown
NCT03795779BiocorpCLL1-CD33 cCAR T cells

CLL1-CD33 cCAR in Patients With Relapsed and/or Refractory, High Risk Hematologic Malignancies

Start: Mar 2018Est. completion: Sep 202220 patients
Phase 1Unknown

Entospletinib (ENTO) as Monotherapy and in Combination With Chemotherapy in Japanese Adults

Start: May 2017Est. completion: Feb 20199 patients
Phase 1Terminated

VitalTraq for the Detection of CRS

Start: Oct 2024Est. completion: Jul 202532 patients
N/ACompleted

A Long-term Follow-up Study of Subjects Who Received CRISPR CAR T Cellular Therapies

Start: Nov 2023Est. completion: Aug 203870 patients
N/AEnrolling By Invitation

Remote Temperature Data for Early Detection of Febrile Neutropenia

Start: Oct 2021Est. completion: Mar 202420 patients
N/ACompleted

Usability, Adherence and Diagnostic Performance of PointCheck in Pediatric Population

Start: Sep 2021Est. completion: Jul 202346 patients
N/ACompleted

Symptom Identification and Management in Patients With Hematological Malignancy During Follow-up Care

Start: Feb 2021Est. completion: Feb 202394 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
4 actively recruiting trials targeting 1,182 patients
22 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.