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Heart Disease

6
Pipeline Programs
23
Companies
20
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
2
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 26 programs with unclassified modality

Competitive Landscape

23 companies ranked by most advanced pipeline stage

Medtronic
MedtronicNJ - Phillipsburg
2 programs
1
Implantable DefibrillatorPhase 41 trial
ICDN/A1 trial
Active Trials
NCT00281099Terminated1,031Est. Jul 2008
NCT00617175Completed1,902Est. Feb 2012
Abbott
AbbottABBOTT PARK, IL
2 programs
1
Unpaired remote monitoring transmitterPhase 41 trial
Unpaired remote monitoring transmitterN/A1 trial
Active Trials
NCT01871090Completed99Est. Jul 2015
NCT02421549Withdrawn0Est. Jan 2016
Pfizer
PfizerNEW YORK, NY
1 program
1
DexmedetomidinePhase 41 trial
Active Trials
NCT02004613Completed798Est. Dec 2020
CSL Seqirus
CSL SeqirusUK - Maidenhead
1 program
1
FibrinogenPhase 3
Artery Therapeutics
Artery TherapeuticsCA - San Ramon
1 program
1
coronary artery bypass graftingPhase 31 trial
Active Trials
NCT00719667Completed2,000Est. Oct 2011
Kite Pharma
Kite PharmaCA - El Segundo
1 program
1
regadenosonPhase 21 trial
Active Trials
NCT00907764Terminated22Est. Apr 2010
Human BioSciences
Human BioSciencesWV - Martinsburg
2 programs
Fish OilN/A1 trial
VICKYN/A1 trial
Active Trials
NCT00536185Completed166Est. Jul 2008
NCT02344433Completed279Est. Oct 2019
Rhythm Pharmaceuticals
2 programs
ICDN/A
Implantable DefibrillatorPHASE_4
AngioDynamics
AngioDynamicsChina - Hong Kong
1 program
AngioVacN/A1 trial
Active Trials
NCT02775565Completed51Est. May 2017
Medinol
MedinolIsrael - Tel Aviv
1 program
BioNIR Ridaforolimus Eluting Coronary StentN/A1 trial
Active Trials
NCT02736344Completed12Est. Sep 2021
Nordic Pharma
Nordic PharmaFrance - Paris
1 program
BurstN/A1 trial
Active Trials
NCT07354347Not Yet Recruiting3,980Est. Jul 2041
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
Comparison Endotracheal Cardiac Output Monitor (ECOM) to a Standard Device in Measuring Heart Blood N/A1 trial
Active Trials
NCT00883857Completed49Est. Nov 2010
MSD
MSDIreland - Ballydine
1 program
Contribution of Hepatic and Intestinal Lipoproteins to Human AtherosclerosisN/A1 trial
Active Trials
NCT01321476Withdrawn0
Merck & Co.
Merck & Co.RAHWAY, NJ
1 program
Contribution of Hepatic and Intestinal Lipoproteins to Human AtherosclerosisN/A
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
Contribution of Hepatic and Intestinal Lipoproteins to Human AtherosclerosisN/A
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
DAiLYN/A1 trial
Active Trials
NCT06629610Recruiting368Est. Apr 2029
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
Non-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF) N/A1 trial
Active Trials
NCT06675552Recruiting438Est. Jun 2027
Supira Medical
Supira MedicalCA - Los Gatos
1 program
Supira SystemN/A1 trial
Active Trials
NCT07407816Recruiting45Est. May 2027
Genome & Company
Genome & CompanyKorea - Suwon
1 program
VICKYN/A
Gilead Sciences
Gilead SciencesFOSTER CITY, CA
1 program
regadenosonPHASE_2
CSL Behring
CSL BehringIL - Bradley
1 program
FibrinogenPHASE_31 trial
Active Trials
NCT01471730Completed119Est. Dec 2014
Daiichi Sankyo
Daiichi SankyoChina - Shanghai
1 program
OlmesartanPHASE_3Small Molecule1 trial
Active Trials
NCT00098137Completed422Est. May 2009
Bracco
BraccoItaly - Milan
1 program
sulphur hexafluoride lipid-type A microspheresPHASE_31 trial
Active Trials
NCT02282163Terminated13Est. Aug 2018

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
AbbottUnpaired remote monitoring transmitter
PfizerDexmedetomidine
MedtronicImplantable Defibrillator
Braccosulphur hexafluoride lipid-type A microspheres
CSL BehringFibrinogen
Artery Therapeuticscoronary artery bypass grafting
Daiichi SankyoOlmesartan
Kite Pharmaregadenoson
Nordic PharmaBurst
Supira MedicalSupira System
AstraZenecaNon-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF)
Oregon TherapeuticsDAiLY
Human BioSciencesVICKY
MedinolBioNIR Ridaforolimus Eluting Coronary Stent
AngioDynamicsAngioVac

Showing 15 of 19 trials with date data

Clinical Trials (20)

Total enrollment: 11,794 patients across 20 trials

NCT02421549AbbottUnpaired remote monitoring transmitter

Remote Interrogation in Rural Emergency Departments

Start: Dec 2014Est. completion: Jan 20160
Phase 4Withdrawn
NCT02004613PfizerDexmedetomidine

Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery

Start: Jun 2013Est. completion: Dec 2020798 patients
Phase 4Completed
NCT00617175MedtronicImplantable Defibrillator

Avoid DeliVering TherApies for Non-sustained Arrhythmias in ICD PatiEnts III

Start: Mar 2008Est. completion: Feb 20121,902 patients
Phase 4Completed
NCT02282163Braccosulphur hexafluoride lipid-type A microspheres

Evaluation of Safety and Efficacy of Lumason in Pediatric Echocardiography

Start: Oct 2015Est. completion: Aug 201813 patients
Phase 3Terminated
NCT01471730CSL BehringFibrinogen

The ZEro PLASma Trial (ZEPLAST): Avoidance of Fresh Frozen Plasma in Cardiac Surgery

Start: Nov 2011Est. completion: Dec 2014119 patients
Phase 3Completed
NCT00719667Artery Therapeuticscoronary artery bypass grafting

German Off Pump Coronary Artery Bypass in Elderly Study

Start: Jul 2008Est. completion: Oct 20112,000 patients
Phase 3Completed
NCT00098137Daiichi SankyoOlmesartan

Trial to Investigate the Efficacy of Olmesartan in Paroxysmal Atrial Fibrillation

Start: Jan 2005Est. completion: May 2009422 patients
Phase 3Completed
NCT00907764Kite Pharmaregadenoson

Stress Echocardiography Study With Regadenoson

Start: Apr 2009Est. completion: Apr 201022 patients
Phase 2Terminated
NCT01321476MSDContribution of Hepatic and Intestinal Lipoproteins to Human Atherosclerosis

Contribution of Hepatic and Intestinal Lipoproteins to Human Atherosclerosis

0
N/AWithdrawn
NCT07354347Nordic PharmaBurst

Optimal Settings for Anti Tachycardia Pacing (ATP) on ICD

Start: Feb 2026Est. completion: Jul 20413,980 patients
N/ANot Yet Recruiting
NCT07407816Supira MedicalSupira System

Feasibility Study of the Supira System in Patients Undergoing HRPCI With Support Beyond the PCI Procedure

Start: Oct 2025Est. completion: May 202745 patients
N/ARecruiting
NCT06675552AstraZenecaNon-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF)

Non-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF) in Germany

Start: Nov 2024Est. completion: Jun 2027438 patients
N/ARecruiting
NCT06629610Oregon TherapeuticsDAiLY

Diet and Active Lifestyle - Yuuyaraq (The Yup'ik Way of Life)

Start: Oct 2024Est. completion: Apr 2029368 patients
N/ARecruiting
NCT02344433Human BioSciencesVICKY

Using Virtual Counselors to Overcome Genetic Literacy Barriers

Start: Nov 2016Est. completion: Oct 2019279 patients
N/ACompleted
NCT02736344MedinolBioNIR Ridaforolimus Eluting Coronary Stent

BIONICS - Pharmacokinetics (PK) Trial

Start: Apr 2016Est. completion: Sep 202112 patients
N/ACompleted
NCT02775565AngioDynamicsAngioVac

Initial Experience With the AngioVac Venous Drainage Cannula

Start: Feb 2016Est. completion: May 201751 patients
N/ACompleted
NCT01871090AbbottUnpaired remote monitoring transmitter

Remote Device Interrogation In The Emergency Department

Start: Sep 2013Est. completion: Jul 201599 patients
N/ACompleted
NCT00883857Angeles TherapeuticsComparison Endotracheal Cardiac Output Monitor (ECOM) to a Standard Device in Measuring Heart Blood

Comparison Endotracheal Cardiac Output Monitor (ECOM) to a Standard Device in Measuring Heart Blood Volume

Start: Oct 2007Est. completion: Nov 201049 patients
N/ACompleted
NCT00536185Human BioSciencesFish Oil

Heart & Health Study

Start: Dec 2006Est. completion: Jul 2008166 patients
N/ACompleted
NCT00281099MedtronicICD

Managed Ventricular Pacing ("MVP") Trial

Start: Oct 2004Est. completion: Jul 20081,031 patients
N/ATerminated

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
3 actively recruiting trials targeting 11,794 patients
23 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.