Chronic Graft Versus Host Disease

8
Pipeline Programs
5
Companies
27
Clinical Trials
8 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
1
6
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 7 programs with unclassified modality

Competitive Landscape

5 companies ranked by most advanced pipeline stage

CT
2 programs
1
1
TQ05105 tabletsPhase 21 trial
TQ05105 TabletPhase 1/21 trial
Active Trials
NCT04944043Active Not RecruitingEst. Dec 2026
NCT06300320RecruitingEst. Apr 2026
Sanofi
SanofiPARIS, France
2 programs
2
BelumosudilPhase 21 trial
BelumosudilPhase 25 trials
Active Trials
NCT07116031Recruiting37Est. Feb 2031
NCT07135973Not Yet Recruiting26Est. Mar 2028
NCT05567406Withdrawn0Est. Aug 2026
+3 more trials
GS
Gilead SciencesFOSTER CITY, CA
2 programs
2
ENTOPhase 2
ENTOPhase 24 trials
Active Trials
NCT03135028Terminated9Est. Feb 2019
NCT02983617Completed36Est. Oct 2020
NCT02701634Terminated66Est. Mar 2018
+1 more trials
Genentech
GenentechCA - Oceanside
1 program
1
Laboratory Biomarker AnalysisPhase 21 trial
Active Trials
NCT02337517Terminated6Est. Jun 2018
Rigel Pharmaceuticals
Rigel PharmaceuticalsSOUTH SAN FRANCISCO, CA
1 program
1
FostamatinibPhase 1Small Molecule1 trial
Active Trials
NCT06233110Recruiting30Est. Jul 2029

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
SanofiBelumosudil
SanofiBelumosudil
SanofiBelumosudil
SanofiBelumosudil
SanofiBelumosudil
SanofiBelumosudil
SanofiBelumosudil
Chia Tai TianQing Pharmaceutical GroupTQ05105 tablets
SanofiBelumosudil
SanofiBelumosudil
SanofiBelumosudil
SanofiBelumosudil
SanofiBelumosudil
SanofiBelumosudil
Gilead SciencesENTO

Showing 15 of 27 trials with date data

Clinical Trials (27)

Total enrollment: 1,260 patients across 27 trials

A Study to Investigate Safety of Belumosudil in Participants Aged 12 Years and Above, With Chronic Graft-versus-host Disease (cGVHD)

Start: Apr 2026Est. completion: Mar 202826 patients
Phase 4Not Yet Recruiting

A Clinical Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Belumosudil in Chinese Adolescents With cGVHD Who Have Had an Inadequate Response to Glucocorticoids or Other Systemic Therapies

Start: Dec 2024Est. completion: May 20266 patients
Phase 4Active Not Recruiting

A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.

Start: Jan 2024Est. completion: Sep 2028260 patients
Phase 3Active Not Recruiting

A Study to Test How Effective Belumosudil Tablets Are for Treating Adult Participants With Chronic Lung Allograft Dysfunction

Start: Oct 2023Est. completion: Jun 2028180 patients
Phase 3Recruiting

A Study of Belumosudil in Children With Chronic Graft Versus Host Disease (schoolROCK)

Start: Dec 2025Est. completion: Feb 203137 patients
Phase 2Recruiting

Safety and Efficacy of Oral Belumosudil in Black or African American, American Indian or Alaska Native, and Native Hawaiian or Other Pacific Islander Male and Female Participants Aged 12 Years and Above With Chronic Graft Versus Host Disease (cGVHD) After At Least 2 Prior Lines of Systemic Therapy

Start: Jun 2025Est. completion: Aug 20260
Phase 2Withdrawn

BElumosudil for Bronchiolitis Obliterans Prevention/Therapy (BEBOP)

Start: May 2024Est. completion: Dec 202745 patients
Phase 2Recruiting

A Clinical Trial of TQ05105 Tablets in the Treatment of Chronic Graft-versus-host Disease

Start: May 2024Est. completion: Apr 2026
Phase 2Recruiting

Belumosudil and Rituximab for Primary Treatment of Chronic Graft-Versus-Host-Disease

Start: Jan 2024Est. completion: Dec 202725 patients
Phase 2Recruiting

Belumosudil for the Pre-emptive Treatment of Patients With Chronic Graft Versus Host Disease

Start: Dec 2023Est. completion: Nov 202882 patients
Phase 2Recruiting

Extended Treatment and Follow-up of Subjects Treated With Belumosudil in Study KD025-208 or Study KD025-213

Start: Feb 2022Est. completion: Jun 202423 patients
Phase 2Completed

Efficacy and Safety of Belumosudil in Subjects With Diffuse Cutaneous Systemic Sclerosis

Start: Mar 2021Est. completion: Dec 202210 patients
Phase 2Terminated

KD025 in Subjects With Diffuse Cutaneous Systemic Sclerosis

Start: Jun 2019Est. completion: Feb 202336 patients
Phase 2Terminated

Efficacy and Safety of KD025 in Subjects With cGVHD After At Least 2 Prior Lines of Systemic Therapy

Start: Oct 2018Est. completion: Dec 2023159 patients
Phase 2Terminated

Safety and Efficacy of the Combination of Tirabrutinib and Entospletinib With and Without Obinutuzumab in Adults With Chronic Lymphocytic Leukemia (CLL)

Start: Apr 2017Est. completion: Oct 202036 patients
Phase 2Completed

A Study to Evaluate the Safety, Tolerability, and Activity of KD025 in Subjects With Chronic Graft Versus Host Disease

Start: Sep 2016Est. completion: May 202254 patients
Phase 2Completed

Efficacy and Tolerability of Entospletinib in Combination With Systemic Corticosteroids as First-Line Therapy in Adults With Chronic Graft Versus Host Disease (cGVHD)

Start: May 2016Est. completion: Mar 201866 patients
Phase 2Terminated
NCT02337517GenentechLaboratory Biomarker Analysis

Vismodegib in Treating Patients With Steroid-Refractory Chronic Graft-Versus-Host Disease

Start: Sep 2015Est. completion: Jun 20186 patients
Phase 2Terminated

Phase I/II Open Label Study of Belumosudil Mesylate Alone, and in Combination With Dexamethasone, in Patients With Relapsed/Refractory Multiple Myeloma

Start: Jan 2024Est. completion: Aug 202936 patients
Phase 1/2Recruiting

A Study of TQ05105 in Patients With Chronic Graft Versus Host Disease

Start: Jun 2021Est. completion: Dec 2026
Phase 1/2Active Not Recruiting

Safety and Efficacy of Entospletinib (ENTO [GS-9973]) Combined With Vincristine (VCR) in Adult Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (NHL)

Start: Feb 2016Est. completion: Jun 201710 patients
Phase 1/2Terminated

Ruxolitinib Plus Fostamatinib for Steroid Refractory cGvHD

Start: Oct 2025Est. completion: Jul 202930 patients
Phase 1Recruiting

A Study to Assess the Effect of Oral Belumosudil on Inhibition of Various Proteins in the Fed State in Healthy Male Subjects

Start: Jul 2022Est. completion: Oct 202252 patients
Phase 1Completed

Entospletinib (ENTO) as Monotherapy and in Combination With Chemotherapy in Japanese Adults

Start: May 2017Est. completion: Feb 20199 patients
Phase 1Terminated

A Study to Determine the Effect of 500 mg Oral Dose of KD025 in Healthy Male and Post-menopausal Female Subjects

Start: Mar 2014Est. completion: Jun 20148 patients
Phase 1Completed

A Study to Determine the Effect of Multiple Oral Doses and Regimens of KD025 in Healthy Male and Post-menopausal Female Subjects

Start: Nov 2013Est. completion: Mar 201432 patients
Phase 1Completed

A Study to Determine the Effect of Multiple Oral Doses of SLx-2119 in Healthy Male Subjects

Start: Sep 2009Est. completion: Dec 200932 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

8 actively recruiting trials targeting 1,260 patients
5 companies competing in this space