Aging

Pipeline Programs

Companies

Clinical Trials

9 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule

375%

Vaccine

125%

+ 65 programs with unclassified modality

Competitive Landscape

32 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Allergy TherapeuticsUK - West Sussex

1 program

Flu VaccinePhase 4Vaccine1 trial

Active Trials

NCT05518500Active Not Recruiting75Est. Dec 2026

Elysium TherapeuticsOH - Akron

1 program

Nicotinamide ribosidePhase 41 trial

Active Trials

NCT05483465Recruiting214Est. Dec 2027

AbbVieNORTH CHICAGO, IL

1 program

OnabotulinumtoxinA 50 UNT [Botox Cosmetic]Phase 41 trial

Active Trials

NCT04240535Not Yet Recruiting20Est. Jul 2020

GaldermaTX - Dallas

2 programs

Botulinum Toxin Type APhase 31 trial

Restylane RefyneN/A1 trial

Active Trials

NCT04162496Completed26Est. Nov 2021

NCT01529203Completed60Est. Apr 2013

Colorado TherapeuticsCO - Louisville

18 programs

Calcium Acetate Oral SolutionPhase 21 trial

MitoQPhase 21 trial

FisetinPhase 1/21 trial

Niagen™Phase 1/21 trial

Time Restricted FeedingPhase 1/21 trial

+13 more programs

Active Trials

NCT03264508Completed25Est. Jun 2021

NCT05300971Recruiting150Est. Feb 2028

NCT05000515Recruiting90Est. Feb 2027

+15 more trials

Angeles Therapeutics

5 programs

RapamycinPhase 21 trial

COMP-4Phase 1/21 trial

InterventionN/A1 trial

PecanN/A1 trial

Tai Chi ChihN/A1 trial

Active Trials

NCT03342729Completed180Est. Mar 2018

NCT06879626Active Not Recruiting60Est. Dec 2026

NCT00280020Completed123Est. Aug 2011

+2 more trials

PfizerNEW YORK, NY

2 programs

CP-424,391Phase 21 trial

AD-EasyN/A1 trial

Active Trials

NCT00328055Completed200Est. Jul 2005

NCT00527046Terminated396Est. Oct 2001

Martin PharmaceuticalsNY - New York

2 programs

fluvastatinPhase 2Small Molecule1 trial

preventive home visitN/A1 trial

Active Trials

NCT00644826Completed336Est. Mar 2010

NCT01045512Terminated96Est. Sep 2014

Alliance PharmaceuticalsUK - Wiltshire

1 program

ClimaraPhase 21 trial

Active Trials

NCT00220454Completed40Est. Mar 2005

SandozAustria - Kundl

1 program

fluvastatinPhase 2Small Molecule

Fountain TherapeuticsCA - South SF

1 program

Plasma TransfusionPhase 1/21 trial

Active Trials

NCT03353597Unknown2,120Est. Dec 2022

Human BioSciences

9 programs

Mental effort in muscle strengtheningPhase 11 trial

Active breakfastN/A1 trial

Combined endurance and resistance trainingN/A

Epigenetics in the Aging ProcessN/A1 trial

Freeze-dried BlueberryN/A1 trial

+4 more programs

Active Trials

NCT03743792Completed6Est. Apr 2023

NCT00242255Completed90Est. Feb 2021

NCT01888848Completed42Est. Feb 2014

+5 more trials

Purdue PharmaCT - Stamford

2 programs

Sham devicePhase 11 trial

Amino AcidsN/A1 trial

Active Trials

NCT04064528Completed20Est. Aug 2023

NCT05543980Completed24Est. Feb 2024

Hexagon PharmaSweden - Stockholm

1 program

Human Umbilical Cord Blood PlasmaPhase 11 trial

Active Trials

NCT03229785Unknown200Est. Aug 2019

Oregon Therapeutics

3 programs

Conversational EngagementN/A1 trial

Share activity data with care teamN/A1 trial

WalnutsN/A1 trial

Active Trials

NCT02871921Completed186Est. Aug 2021

NCT02566239Completed96Est. Aug 2019

NCT06942351Recruiting80Est. May 2029

Innovation PharmaceuticalsMA - Wakefield

2 programs

FIT to Grow Old - Functionality of the Immune System and Healthy AgingN/A

Goal Management TrainingN/A1 trial

Active Trials

NCT03602768Completed800Est. Aug 2020

City TherapeuticsMA - Cambridge

2 programs

InterventionN/A

None of interventionN/A1 trial

Active Trials

NCT05468905RecruitingEst. Dec 2026

LundbeckDenmark - Copenhagen

1 program

Biological Aging, Medication, Malnutrition and Inflammation Among Acutely Ill and Healthy Elderly.N/A1 trial

Active Trials

NCT03052192Unknown212Est. Dec 2019

Shield TherapeuticsMA - Wellesley

1 program

Community-based personalized careN/A1 trial

Active Trials

NCT03263169Unknown1,100Est. Sep 2018

ETSMO - Rolla

1 program

Counterclockwise programN/A1 trial

Active Trials

NCT03552042Completed90Est. Dec 2020

Novo NordiskBAGSVAERD DENMARK, Denmark

1 program

D-β-hydroxybutyrate/D 1,3 butanediol monoesterN/A1 trial

Active Trials

NCT05732909Completed25Est. Jan 2024

UNION therapeutics

1 program

ICOPEN/A1 trial

Active Trials

NCT05933798Completed2,148Est. Aug 2021

Johnson & JohnsonNEW BRUNSWICK, NJ

1 program

Long-term Caloric Restriction and Cellular Aging MarkersN/A1 trial

Active Trials

NCT01256840Completed71Est. Aug 2014

GenomicsUK - Oxford

1 program

NMNN/A1 trial

Active Trials

NCT06592859Recruiting240Est. Dec 2026

Cognition TherapeuticsPA - Pittsburgh

1 program

Nitrate enriched beetroot juiceN/A1 trial

Active Trials

NCT07572266Not Yet Recruiting226Est. May 2031

Ambrosia BiosciencesCO - Boulder

1 program

PlasmaN/A1 trial

Active Trials

NCT02803554Completed200Est. Jan 2018

LabcorpBURLINGTON, NC

1 program

Positive Emotion Skills InterventionN/A

Fitzpatrick Company

1 program

Secret RFN/A1 trial

Active Trials

NCT03426098Unknown40Est. Jun 2019

BGI

1 program

Study of Microbiota in Longevity County, YongfuN/A1 trial

Active Trials

NCT04210934Completed160Est. May 2016

ExeGi Pharma

1 program

VisbiomeN/A1 trial

Active Trials

NCT07415707Recruiting20Est. Apr 2027

+2 more companies

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

2030

2031

Elysium TherapeuticsNicotinamide riboside

Allergy TherapeuticsFlu Vaccine

AbbVieOnabotulinumtoxinA 50 UNT [Botox Cosmetic]

GaldermaBotulinum Toxin Type A

Colorado TherapeuticsCalcium Acetate Oral Solution

Colorado TherapeuticsMitoQ

Angeles TherapeuticsRapamycin

Martin Pharmaceuticalsfluvastatin

Alliance PharmaceuticalsClimara

PfizerCP-424,391

Colorado TherapeuticsFisetin

Angeles TherapeuticsCOMP-4

Fountain TherapeuticsPlasma Transfusion

Colorado TherapeuticsTime Restricted Feeding

Colorado TherapeuticsNiagen™

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 14,449 patients across 50 trials

NCT05483465 Elysium TherapeuticsNicotinamide riboside

The Effect of NAD Supplementation on Brain Vascular Health in Aging

Start: May 2023Est. completion: Dec 2027214 patients

Phase 4Recruiting

NCT05518500 Allergy TherapeuticsFlu Vaccine

A Deep Longitudinal Analysis of Next Generation Influenza Vaccines in Older Adults

Start: Aug 2022Est. completion: Dec 202675 patients

Phase 4Active Not Recruiting

NCT04240535 AbbVieOnabotulinumtoxinA 50 UNT [Botox Cosmetic]

Evaluation of the Safety and Efficacy of OnabotulinumtoxinA to the Depressor Anguli Oris

Start: Jan 2020Est. completion: Jul 202020 patients

Phase 4Not Yet Recruiting

NCT01529203 GaldermaBotulinum Toxin Type A

Subjects' Satisfaction on Pan Facial Aesthetic Enhancement After Treatment With Azzalure® and the Restylane® Range

Start: Feb 2012Est. completion: Apr 201360 patients

Phase 3Completed

NCT05424263 Colorado TherapeuticsCalcium Acetate Oral Solution

Acetate and Age-associated Arterial Dysfunction

Start: Sep 2022Est. completion: Sep 202566 patients

Phase 2Unknown

NCT04851288 Colorado TherapeuticsMitoQ

Mitochondrial-targeted Antioxidant Supplementation for Improving Age-related Vascular Dysfunction in Humans

Start: Apr 2021Est. completion: Dec 2026112 patients

Phase 2Active Not Recruiting

NCT04488601 Angeles TherapeuticsRapamycin

Participatory Evaluation (of) Aging (With) Rapamycin (for) Longevity Study

Start: Jan 2020Est. completion: Dec 2023129 patients

Phase 2Completed

NCT01045512 Martin Pharmaceuticalsfluvastatin

The Role of the "Inflammatory/ Pathogen Burden" for Cardiac Ageing

Start: Oct 2009Est. completion: Sep 201496 patients

Phase 2Terminated

NCT00220454 Alliance PharmaceuticalsClimara

Effect of Estrogen & Stress for Postmenopausal Women

Start: Dec 2002Est. completion: Mar 200540 patients

Phase 2Completed

NCT00527046 PfizerCP-424,391

Effects Of An Oral Growth Hormone Secretagogue In Older Functionally Limited Adults

Start: Dec 1999Est. completion: Oct 2001396 patients

Phase 2Terminated

NCT06133634 Colorado TherapeuticsFisetin

Fisetin to Improve Vascular Function in Older Adults

Start: Sep 2023Est. completion: Mar 202770 patients

Phase 1/2Active Not Recruiting

NCT05595915 Angeles TherapeuticsCOMP-4

COMP-4 Supplementation and Brachial Artery FMD

Start: Jun 2023Est. completion: Nov 202532 patients

Phase 1/2Completed

NCT03353597 Fountain TherapeuticsPlasma Transfusion

Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects

Start: May 2018Est. completion: Dec 20222,120 patients

Phase 1/2Unknown

NCT02970188 Colorado TherapeuticsTime Restricted Feeding

The Effect of Time-restricted Feeding on Physiological Function in Middle-aged and Older Adults

Start: Apr 2016Est. completion: Sep 201912 patients

Phase 1/2Unknown

NCT02921659 Colorado TherapeuticsNiagen™

Safety & Efficacy of Nicotinamide Riboside Supplementation for Improving Physiological Function in Middle-Aged and Older Adults

Start: Apr 2015Est. completion: Oct 201630 patients

Phase 1/2Completed

NCT01384591 Lantheus Medical ImagingN-acetylcysteine

Pilot Study of Losartan and N-acetylcysteine as Inhibitors of Muscle Oxidative Stress in Elderly

Start: Jul 2011Est. completion: May 20156 patients

Phase 1/2Completed

NCT05686967 Colorado TherapeuticsMitoQ

MitoQ and Exercise Effects on Vascular Health

Start: Jan 2023Est. completion: Nov 202522 patients

Phase 1Active Not Recruiting

NCT05543980 Purdue PharmaSham device

Leg Heat Therapy in Elderly Individuals

Start: Sep 2022Est. completion: Feb 202424 patients

Phase 1Completed

NCT03229785 Hexagon PharmaHuman Umbilical Cord Blood Plasma

Quality of Life Improvements With Cord Blood Plasma

Start: Apr 2018Est. completion: Aug 2019200 patients

Phase 1Unknown

NCT00059436 Human BioSciencesMental effort in muscle strengthening

Mental Effort and Muscle Strength

Start: Oct 1999

Phase 1Completed

NCT07572266 Cognition TherapeuticsNitrate enriched beetroot juice

Adjuvant Nitrate to Boost Exercise-induced Health Benefits in Older Adults

Start: Jul 2026Est. completion: May 2031226 patients

N/ANot Yet Recruiting

NCT07406243 Colorado TherapeuticsMitoquinone

Oral Antioxidant Therapy Targeted to the Mitochondria for Improving Brain Artery Health in Postmenopausal Women

Start: Apr 2026Est. completion: Jul 203086 patients

N/ANot Yet Recruiting

NCT07415707 ExeGi PharmaVisbiome

The GLUCID Study: Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers

Start: Feb 2026Est. completion: Apr 202720 patients

N/ARecruiting

NCT07334106 Human BioSciencesPositive Emotion Skills Intervention

Emotional Well-being and Measures of Healthy Aging

Start: Sep 2025Est. completion: Aug 202880 patients

N/ARecruiting

NCT06940037 Human BioSciencesProgressive Resistance Training

The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults

Start: Aug 2025Est. completion: Aug 2030300 patients

N/ARecruiting

NCT03803566 Colorado TherapeuticsPegboard practice

Age-independent Decline in Manual Dexterity of Middle-aged and Older Adults

Start: Aug 2025Est. completion: Jul 20260

N/AWithdrawn

NCT06942351 Oregon TherapeuticsWalnuts

Effect of Walnuts on Cognitive Function and Gut Microbiome in Older Adults

Start: Jun 2025Est. completion: May 202980 patients

N/ARecruiting

NCT06879626 Angeles TherapeuticsPecan

Effect of Snacks on Aging

Start: May 2025Est. completion: Dec 202660 patients

N/AActive Not Recruiting

NCT06592859 GenomicsNMN

Intervention of Nicotinamide Mononucleotide in Middle-aged and Elderly People

Start: Aug 2023Est. completion: Dec 2026240 patients

N/ARecruiting

NCT05377411 Soterix MedicaltDCS

SMART Stimulation: Precision Neuromodulation of Cognition in Older Adults

Start: Jan 2023Est. completion: Jun 202433 patients

N/ACompleted

NCT05732909 Novo NordiskD-β-hydroxybutyrate/D 1,3 butanediol monoester

The Metabolic Effects of β-hydroxybutyrate on Working Skeletal Muscle

Start: Dec 2022Est. completion: Jan 202425 patients

N/ACompleted

NCT05300971 Colorado TherapeuticsHeat therapy

Passive Heat Therapy for Lowering Systolic Blood Pressure and Improving Vascular Function in Mid-life and Older Adults

Start: Aug 2022Est. completion: Feb 2028150 patients

N/ARecruiting

NCT05492240 Colorado Therapeuticsi-STRONGER

Advancing Rehabilitation Paradigms for Older Adults in Skilled Nursing Facilities

Start: Jul 2022Est. completion: Sep 20254,383 patients

N/ACompleted

NCT05000515 Colorado TherapeuticsHigh-resistance inspiratory muscle strength training

Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise

Start: Apr 2022Est. completion: Feb 202790 patients

N/ARecruiting

NCT04630418 Colorado TherapeuticsNanoSilk Cosmo

NanoSilk Cosmo: Evaluation of a Novel Silk Complex on Biophysical Parameters Related to Skin Aging

Start: May 2021Est. completion: Jan 202246 patients

N/ACompleted

NCT05468905 City TherapeuticsNone of intervention

China Longitudinal Aging and Cognitive Impairment Study

Start: Jan 2021Est. completion: Dec 2026

N/ARecruiting

NCT05933798 UNION therapeuticsICOPE

China Pilot of ICOPE (Integrated Care for Older People) in Chaoyang

Start: Sep 2020Est. completion: Aug 20212,148 patients

N/ACompleted

NCT04162496 GaldermaRestylane Refyne

Restylane Refyne for Correction of Horizontal Neck Rhytides

Start: Aug 2020Est. completion: Nov 202126 patients

N/ACompleted

NCT04064528 Purdue PharmaAmino Acids

Effects of Age on Amino Acid Delivery to Tendon

Start: Sep 2019Est. completion: Aug 202320 patients

N/ACompleted

NCT04239898 Colorado TherapeuticsRed cabbage microgreens

Microgreen Consumption for Healthy Aging

Start: Jul 2019Est. completion: Nov 201926 patients

N/ACompleted

NCT03743792 Human BioSciencesActive breakfast

Acute Raspberry Intake on Metabolic Control and Cognitive Function

Start: Feb 2019Est. completion: Apr 20236 patients

N/ACompleted

NCT03552042 ETSCounterclockwise program

Ageing as a Mindset: A Counterclockwise Experiment to Rejuvenate Older Adults

Start: Jul 2018Est. completion: Dec 202090 patients

N/ACompleted

NCT03602768 Innovation PharmaceuticalsGoal Management Training

Evaluation of the Online Memory & Aging Program and Online Goal Management Training

Start: Jun 2018Est. completion: Aug 2020800 patients

N/ACompleted

NCT02871921 Oregon TherapeuticsConversational Engagement

Internet-based Conversational Engagement Clinical Trial

Start: Jun 2018Est. completion: Aug 2021186 patients

N/ACompleted

NCT03426098 Fitzpatrick CompanySecret RF

Secret Micro-Needle Fractional RF System® for the Treatment of Facial Wrinkles

Start: Feb 2018Est. completion: Jun 201940 patients

N/AUnknown

NCT03264508 Colorado TherapeuticsHeat therapy

Passive Heat Therapy and Age-associated Physiological Function

Start: Oct 2017Est. completion: Jun 202125 patients

N/ACompleted

NCT03162913 Human BioSciencesStrawberry

The Effects of Strawberry Supplementation on Memory and Gait Among Over-weight Older Adults

Start: Oct 2017Est. completion: Oct 202347 patients

N/ACompleted

NCT03263169 Shield TherapeuticsCommunity-based personalized care

Community-based Personalized Care and QOL

Start: Jul 2017Est. completion: Sep 20181,100 patients

N/AUnknown

NCT03342729 Angeles TherapeuticsIntervention

Aging Mastery Program® (AMP) Evaluation

Start: May 2017Est. completion: Mar 2018180 patients

N/ACompleted

NCT03052192 LundbeckBiological Aging, Medication, Malnutrition and Inflammation Among Acutely Ill and Healthy Elderly.

Biological Aging, Medication, Malnutrition and Inflammation Among Acutely Ill and Healthy Elderly.

Start: Nov 2016Est. completion: Dec 2019212 patients

N/AUnknown

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals

9 actively recruiting trials targeting 14,449 patients

30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.