Aging

Pipeline Programs

Companies

Clinical Trials

10 recruiting

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule

375%

Vaccine

125%

+ 63 programs with unclassified modality

Competitive Landscape

30 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Allergy TherapeuticsUK - West Sussex

1 program

Flu VaccinePhase 4Vaccine1 trial

Active Trials

NCT05518500Active Not Recruiting75Est. Dec 2026

Elysium TherapeuticsOH - Akron

1 program

Nicotinamide ribosidePhase 41 trial

Active Trials

NCT05483465Recruiting214Est. Dec 2027

AbbVieNORTH CHICAGO, IL

1 program

OnabotulinumtoxinA 50 UNT [Botox Cosmetic]Phase 41 trial

Active Trials

NCT04240535Not Yet Recruiting20Est. Jul 2020

GaldermaTX - Dallas

2 programs

Botulinum Toxin Type APhase 31 trial

Restylane RefyneN/A1 trial

Active Trials

NCT04162496Active Not Recruiting24Est. Sep 2021

NCT01529203Completed60Est. Apr 2013

Colorado TherapeuticsCO - Louisville

18 programs

Calcium Acetate Oral SolutionPhase 21 trial

MitoQPhase 21 trial

FisetinPhase 1/21 trial

Niagen™Phase 1/21 trial

Time Restricted FeedingPhase 1/21 trial

+13 more programs

Active Trials

NCT05300971Recruiting150Est. Feb 2028

NCT03264508Completed25Est. Jun 2021

NCT05000515Recruiting90Est. Feb 2027

+15 more trials

Angeles Therapeutics

5 programs

RapamycinPhase 21 trial

COMP-4Phase 1/21 trial

InterventionN/A1 trial

PecanN/A1 trial

Tai Chi ChihN/A1 trial

Active Trials

NCT03342729Completed180Est. Mar 2018

NCT06879626Recruiting60Est. Jun 2026

NCT00280020Completed123Est. Aug 2011

+2 more trials

PfizerNEW YORK, NY

2 programs

CP-424,391Phase 21 trial

AD-EasyN/A1 trial

Active Trials

NCT00328055Completed200Est. Jul 2005

NCT00527046Terminated396Est. Oct 2001

Martin PharmaceuticalsNY - New York

2 programs

fluvastatinPhase 2Small Molecule

preventive home visitN/A1 trial

Active Trials

NCT00644826Completed336Est. Mar 2010

Alliance PharmaceuticalsUK - Wiltshire

1 program

ClimaraPhase 21 trial

Active Trials

NCT00220454Completed40Est. Mar 2005

SandozAustria - Kundl

1 program

fluvastatinPhase 2Small Molecule1 trial

Active Trials

NCT01045512Terminated96Est. Sep 2014

Fountain TherapeuticsCA - South SF

1 program

Plasma TransfusionPhase 1/21 trial

Active Trials

NCT03353597Unknown2,120Est. Dec 2022

Human BioSciencesWV - Martinsburg

9 programs

Mental effort in muscle strengtheningPhase 11 trial

Active breakfastN/A1 trial

Combined endurance and resistance trainingN/A

Epigenetics in the Aging ProcessN/A1 trial

Freeze-dried BlueberryN/A1 trial

+4 more programs

Active Trials

NCT03743792Completed6Est. Apr 2023

NCT00242255Completed90Est. Feb 2021

NCT01888848Completed42Est. Feb 2014

+5 more trials

Purdue PharmaCT - Stamford

2 programs

Sham devicePhase 11 trial

Amino AcidsN/A1 trial

Active Trials

NCT04064528Completed20Est. Aug 2023

NCT05543980Completed24Est. Feb 2024

Hexagon PharmaSweden - Stockholm

1 program

Human Umbilical Cord Blood PlasmaPhase 11 trial

Active Trials

NCT03229785Unknown200Est. Aug 2019

Oregon Therapeutics

3 programs

Conversational EngagementN/A1 trial

Share activity data with care teamN/A1 trial

WalnutsN/A1 trial

Active Trials

NCT02871921Completed186Est. Aug 2021

NCT02566239Completed96Est. Aug 2019

NCT06942351Recruiting80Est. May 2029

Innovation PharmaceuticalsMA - Wakefield

2 programs

FIT to Grow Old - Functionality of the Immune System and Healthy AgingN/A

Goal Management TrainingN/A1 trial

Active Trials

NCT03602768Completed800Est. Aug 2020

City TherapeuticsMA - Cambridge

2 programs

InterventionN/A

None of interventionN/A1 trial

Active Trials

NCT05468905RecruitingEst. Dec 2026

LundbeckDenmark - Copenhagen

1 program

Biological Aging, Medication, Malnutrition and Inflammation Among Acutely Ill and Healthy Elderly.N/A1 trial

Active Trials

NCT03052192Unknown212Est. Dec 2019

Shield TherapeuticsMA - Wellesley

1 program

Community-based personalized careN/A1 trial

Active Trials

NCT03263169Unknown1,100Est. Sep 2018

Novo NordiskBAGSVAERD DENMARK, Denmark

1 program

D-β-hydroxybutyrate/D 1,3 butanediol monoesterN/A1 trial

Active Trials

NCT05732909Completed25Est. Jan 2024

UNION therapeutics

1 program

ICOPEN/A1 trial

Active Trials

NCT05933798Completed2,148Est. Aug 2021

Johnson & JohnsonNEW BRUNSWICK, NJ

1 program

Long-term Caloric Restriction and Cellular Aging MarkersN/A1 trial

Active Trials

NCT01256840Completed71Est. Aug 2014

GenomicsUK - Oxford

1 program

NMNN/A1 trial

Active Trials

NCT06592859Recruiting240Est. Dec 2026

Ambrosia BiosciencesCO - Boulder

1 program

PlasmaN/A1 trial

Active Trials

NCT02803554Completed200Est. Jan 2018

LabcorpBURLINGTON, NC

1 program

Positive Emotion Skills InterventionN/A

Fitzpatrick Company

1 program

Secret RFN/A1 trial

Active Trials

NCT03426098Unknown40Est. Jun 2019

BGI

1 program

Study of Microbiota in Longevity County, YongfuN/A1 trial

Active Trials

NCT04210934Completed160Est. May 2016

ExeGi PharmaMD - Rockville

1 program

VisbiomeN/A1 trial

Active Trials

NCT07415707Recruiting20Est. Apr 2027

Soterix MedicalNJ - Woodbridge

1 program

tDCSN/A1 trial

Active Trials

NCT05377411Completed33Est. Jun 2024

Lantheus Medical ImagingMA - Bedford

1 program

N-acetylcysteinePHASE_1_21 trial

Active Trials

NCT01384591Completed6Est. May 2015

Trial Timeline

Clinical trial activity over time

2021

2022

2023

2024

2025

2026

2027

2028

2029

2030

Elysium TherapeuticsNicotinamide riboside

Allergy TherapeuticsFlu Vaccine

AbbVieOnabotulinumtoxinA 50 UNT [Botox Cosmetic]

GaldermaBotulinum Toxin Type A

Colorado TherapeuticsCalcium Acetate Oral Solution

Colorado TherapeuticsMitoQ

Angeles TherapeuticsRapamycin

Sandozfluvastatin

Alliance PharmaceuticalsClimara

PfizerCP-424,391

Colorado TherapeuticsFisetin

Angeles TherapeuticsCOMP-4

Fountain TherapeuticsPlasma Transfusion

Colorado TherapeuticsTime Restricted Feeding

Colorado TherapeuticsNiagen™

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 14,491 patients across 50 trials

NCT05483465 Elysium TherapeuticsNicotinamide riboside

The Effect of NAD Supplementation on Brain Vascular Health in Aging

Start: May 2023Est. completion: Dec 2027214 patients

Phase 4Recruiting

NCT05518500 Allergy TherapeuticsFlu Vaccine

A Deep Longitudinal Analysis of Next Generation Influenza Vaccines in Older Adults

Start: Aug 2022Est. completion: Dec 202675 patients

Phase 4Active Not Recruiting

NCT04240535 AbbVieOnabotulinumtoxinA 50 UNT [Botox Cosmetic]

Evaluation of the Safety and Efficacy of OnabotulinumtoxinA to the Depressor Anguli Oris

Start: Jan 2020Est. completion: Jul 202020 patients

Phase 4Not Yet Recruiting

NCT01529203 GaldermaBotulinum Toxin Type A

Subjects' Satisfaction on Pan Facial Aesthetic Enhancement After Treatment With Azzalure® and the Restylane® Range

Start: Feb 2012Est. completion: Apr 201360 patients

Phase 3Completed

NCT05424263 Colorado TherapeuticsCalcium Acetate Oral Solution

Acetate and Age-associated Arterial Dysfunction

Start: Sep 2022Est. completion: Sep 202566 patients

Phase 2Unknown

NCT04851288 Colorado TherapeuticsMitoQ

Mitochondrial-targeted Antioxidant Supplementation for Improving Age-related Vascular Dysfunction in Humans

Start: Apr 2021Est. completion: Dec 2026112 patients

Phase 2Active Not Recruiting

NCT04488601 Angeles TherapeuticsRapamycin

Participatory Evaluation (of) Aging (With) Rapamycin (for) Longevity Study

Start: Jan 2020Est. completion: Dec 2023129 patients

Phase 2Completed

NCT01045512 Sandozfluvastatin

The Role of the "Inflammatory/ Pathogen Burden" for Cardiac Ageing

Start: Oct 2009Est. completion: Sep 201496 patients

Phase 2Terminated

NCT00220454 Alliance PharmaceuticalsClimara

Effect of Estrogen & Stress for Postmenopausal Women

Start: Dec 2002Est. completion: Mar 200540 patients

Phase 2Completed

NCT00527046 PfizerCP-424,391

Effects Of An Oral Growth Hormone Secretagogue In Older Functionally Limited Adults

Start: Dec 1999Est. completion: Oct 2001396 patients

Phase 2Terminated

NCT06133634 Colorado TherapeuticsFisetin

Fisetin to Improve Vascular Function in Older Adults

Start: Sep 2023Est. completion: Mar 202770 patients

Phase 1/2Active Not Recruiting

NCT05595915 Angeles TherapeuticsCOMP-4

COMP-4 Supplementation and Brachial Artery FMD

Start: Jun 2023Est. completion: Nov 202532 patients

Phase 1/2Completed

NCT03353597 Fountain TherapeuticsPlasma Transfusion

Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects

Start: May 2018Est. completion: Dec 20222,120 patients

Phase 1/2Unknown

NCT02970188 Colorado TherapeuticsTime Restricted Feeding

The Effect of Time-restricted Feeding on Physiological Function in Middle-aged and Older Adults

Start: Apr 2016Est. completion: Sep 201912 patients

Phase 1/2Unknown

NCT02921659 Colorado TherapeuticsNiagen™

Safety & Efficacy of Nicotinamide Riboside Supplementation for Improving Physiological Function in Middle-Aged and Older Adults

Start: Apr 2015Est. completion: Oct 201630 patients

Phase 1/2Completed

NCT01384591 Lantheus Medical ImagingN-acetylcysteine

Pilot Study of Losartan and N-acetylcysteine as Inhibitors of Muscle Oxidative Stress in Elderly

Start: Jul 2011Est. completion: May 20156 patients

Phase 1/2Completed

NCT05686967 Colorado TherapeuticsMitoQ

MitoQ and Exercise Effects on Vascular Health

Start: Jan 2023Est. completion: Nov 202522 patients

Phase 1Active Not Recruiting

NCT05543980 Purdue PharmaSham device

Leg Heat Therapy in Elderly Individuals

Start: Sep 2022Est. completion: Feb 202424 patients

Phase 1Completed

NCT03229785 Hexagon PharmaHuman Umbilical Cord Blood Plasma

Quality of Life Improvements With Cord Blood Plasma

Start: Apr 2018Est. completion: Aug 2019200 patients

Phase 1Unknown

NCT00059436 Human BioSciencesMental effort in muscle strengthening

Mental Effort and Muscle Strength

Start: Oct 1999

Phase 1Completed

NCT07406243 Colorado TherapeuticsMitoquinone

Oral Antioxidant Therapy Targeted to the Mitochondria for Improving Brain Artery Health in Postmenopausal Women

Start: Apr 2026Est. completion: Jul 203086 patients

N/ANot Yet Recruiting

NCT07415707 ExeGi PharmaVisbiome

The GLUCID Study: Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers

Start: Feb 2026Est. completion: Apr 202720 patients

N/ARecruiting

NCT07334106 Human BioSciencesPositive Emotion Skills Intervention

Emotional Well-being and Measures of Healthy Aging

Start: Sep 2025Est. completion: Aug 202880 patients

N/ARecruiting

NCT06940037 Human BioSciencesProgressive Resistance Training

The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults

Start: Aug 2025Est. completion: Aug 2030300 patients

N/ARecruiting

NCT03803566 Colorado TherapeuticsPegboard practice

Age-independent Decline in Manual Dexterity of Middle-aged and Older Adults

Start: Aug 2025Est. completion: Jul 20260

N/AWithdrawn

NCT06942351 Oregon TherapeuticsWalnuts

Effect of Walnuts on Cognitive Function and Gut Microbiome in Older Adults

Start: Jun 2025Est. completion: May 202980 patients

N/ARecruiting

NCT06879626 Angeles TherapeuticsPecan

Effect of Snacks on Aging

Start: May 2025Est. completion: Jun 202660 patients

N/ARecruiting

NCT06592859 GenomicsNMN

Quzhou Population Cohort Research Project (Aging Related Research: Intervention of Nicotinamide Mononucleotide in Middle-aged and Elderly People)

Start: Aug 2023Est. completion: Dec 2026240 patients

N/ARecruiting

NCT05377411 Soterix MedicaltDCS

SMART Stimulation: Precision Neuromodulation of Cognition in Older Adults

Start: Jan 2023Est. completion: Jun 202433 patients

N/ACompleted

NCT05732909 Novo NordiskD-β-hydroxybutyrate/D 1,3 butanediol monoester

The Metabolic Effects of β-hydroxybutyrate on Working Skeletal Muscle

Start: Dec 2022Est. completion: Jan 202425 patients

N/ACompleted

NCT05300971 Colorado TherapeuticsHeat therapy

Passive Heat Therapy for Lowering Systolic Blood Pressure and Improving Vascular Function in Mid-life and Older Adults

Start: Aug 2022Est. completion: Feb 2028150 patients

N/ARecruiting

NCT05492240 Colorado Therapeuticsi-STRONGER

Advancing Rehabilitation Paradigms for Older Adults in Skilled Nursing Facilities

Start: Jul 2022Est. completion: Sep 20254,383 patients

N/ACompleted

NCT05000515 Colorado TherapeuticsHigh-resistance inspiratory muscle strength training

Inspiratory Muscle Strength Training for Lowering Blood Pressure and Improving Endothelial Function in Postmenopausal Women: Comparison With "Standard of Care" Aerobic Exercise

Start: Apr 2022Est. completion: Feb 202790 patients

N/ARecruiting

NCT04630418 Colorado TherapeuticsNanoSilk Cosmo

NanoSilk Cosmo: Evaluation of a Novel Silk Complex on Biophysical Parameters Related to Skin Aging

Start: May 2021Est. completion: Jan 202246 patients

N/ACompleted

NCT05468905 City TherapeuticsNone of intervention

China Longitudinal Aging and Cognitive Impairment Study

Start: Jan 2021Est. completion: Dec 2026

N/ARecruiting

NCT05933798 UNION therapeuticsICOPE

China Pilot of ICOPE (Integrated Care for Older People) in Chaoyang

Start: Sep 2020Est. completion: Aug 20212,148 patients

N/ACompleted

NCT04162496 GaldermaRestylane Refyne

Restylane Refyne for Correction of Horizontal Neck Rhytides

Start: Aug 2020Est. completion: Sep 202124 patients

N/AActive Not Recruiting

NCT04064528 Purdue PharmaAmino Acids

Effects of Age on Amino Acid Delivery to Tendon

Start: Sep 2019Est. completion: Aug 202320 patients

N/ACompleted

NCT04239898 Colorado TherapeuticsRed cabbage microgreens

Microgreen Consumption for Healthy Aging

Start: Jul 2019Est. completion: Nov 201926 patients

N/ACompleted

NCT03743792 Human BioSciencesActive breakfast

Acute Raspberry Intake on Metabolic Control and Cognitive Function

Start: Feb 2019Est. completion: Apr 20236 patients

N/ACompleted

NCT03602768 Innovation PharmaceuticalsGoal Management Training

Evaluation of the Online Memory & Aging Program and Online Goal Management Training

Start: Jun 2018Est. completion: Aug 2020800 patients

N/ACompleted

NCT02871921 Oregon TherapeuticsConversational Engagement

Internet-based Conversational Engagement Clinical Trial

Start: Jun 2018Est. completion: Aug 2021186 patients

N/ACompleted

NCT03426098 Fitzpatrick CompanySecret RF

Secret Micro-Needle Fractional RF System® for the Treatment of Facial Wrinkles

Start: Feb 2018Est. completion: Jun 201940 patients

N/AUnknown

NCT03264508 Colorado TherapeuticsHeat therapy

Passive Heat Therapy and Age-associated Physiological Function

Start: Oct 2017Est. completion: Jun 202125 patients

N/ACompleted

NCT03162913 Human BioSciencesStrawberry

The Effects of Strawberry Supplementation on Memory and Gait Among Over-weight Older Adults

Start: Oct 2017Est. completion: Oct 202347 patients

N/ACompleted

NCT03263169 Shield TherapeuticsCommunity-based personalized care

Community-based Personalized Care and QOL

Start: Jul 2017Est. completion: Sep 20181,100 patients

N/AUnknown

NCT03342729 Angeles TherapeuticsIntervention

Aging Mastery Program® (AMP) Evaluation

Start: May 2017Est. completion: Mar 2018180 patients

N/ACompleted

NCT03052192 LundbeckBiological Aging, Medication, Malnutrition and Inflammation Among Acutely Ill and Healthy Elderly.

Biological Aging, Medication, Malnutrition and Inflammation Among Acutely Ill and Healthy Elderly.

Start: Nov 2016Est. completion: Dec 2019212 patients

N/AUnknown

NCT02803554 Ambrosia BiosciencesPlasma

Young Donor Plasma Transfusion and Age-Related Biomarkers

Start: Jun 2016Est. completion: Jan 2018200 patients

N/ACompleted

NCT04210934 BGIStudy of Microbiota in Longevity County, Yongfu

Study of Microbiota in Longevity County, Yongfu

Start: May 2016Est. completion: May 2016160 patients

N/ACompleted

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals

10 actively recruiting trials targeting 14,491 patients

30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.