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Acute Graft Versus Host Disease

3
Pipeline Programs
4
Companies
9
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
2
0
0
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
2100%
+ 2 programs with unclassified modality

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Astex Pharmaceuticals
Astex PharmaceuticalsUK - Cambridge
1 program
1
pentostatinPhase 3Small Molecule5 trials
Active Trials
NCT00541034Completed49Est. Jan 2016
NCT00144430Completed60Est. Aug 2008
NCT00254163Completed184Est. Sep 2011
+2 more trials
Design Pharmaceuticals
1 program
1
Adult Allogeneic Mesenchymal cells from adipose tissue.Phase 1/2
Sandoz
SandozAustria - Kundl
1 program
1
RuxolitinibPhase 1/2Small Molecule1 trial
Active Trials
NCT03491215Completed45Est. Feb 2023
Design Therapeutics
1 program
Adult Allogeneic Mesenchymal cells from adipose tissue.PHASE_1_21 trial
Active Trials
NCT02687646Completed16Est. Jan 2022

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Astex Pharmaceuticalspentostatin
Astex Pharmaceuticalspentostatin
Astex Pharmaceuticalspentostatin
Astex Pharmaceuticalspentostatin
Astex Pharmaceuticalspentostatin
SandozRuxolitinib
Design TherapeuticsAdult Allogeneic Mesenchymal cells from adipose tissue.
Astex Pharmaceuticalspentostatin
Astex Pharmaceuticalspentostatin

Clinical Trials (9)

Total enrollment: 644 patients across 9 trials

Fludarabine, Cyclophosphamide, and Rituximab Versus Pentostatin, Cyclophosphamide, and Rituximab in Previously Untreated or Treated B-Cell Chronic Lymphocytic Leukemia Patients

Start: Dec 2003Est. completion: Sep 2011184 patients
Phase 3Completed

Pentostatin, Cyclophosphamide, and Rituximab in Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia

Start: May 2005Est. completion: Jan 201649 patients
Phase 2Completed

Pentostatin for High Risk and Refractory Chronic Graft Versus Host Disease in Children

Start: Jan 2004Est. completion: Aug 200860 patients
Phase 2Completed

Pentostatin, and Rituximab With and Without Cyclophosphamide for Previously Untreated B-Chronic Lymphocytic Leukemia

Start: Jul 2002Est. completion: Sep 200628 patients
Phase 2Completed

Safety and Efficacy of Pentostatin and Low Dose TBI With Allogenic Peripheral Blood Stem Cell Transplant

Start: Dec 2000Est. completion: Dec 200876 patients
Phase 2Completed

Study of Pharmacokinetics, Activity and Safety of Ruxolitinib in Pediatric Patients With Grade II-IV Acute Graft vs. Host Disease

Start: Feb 2019Est. completion: Feb 202345 patients
Phase 1/2Completed
NCT02687646Design TherapeuticsAdult Allogeneic Mesenchymal cells from adipose tissue.

Clinical Trial With MSC for Graft Versus Host Disease Treatment

Start: Feb 2017Est. completion: Jan 202216 patients
Phase 1/2Completed

Dose-finding Study Using Pentostatin for Injection in the Treatment of Steroid-refractory aGvHD

Start: Jan 2002Est. completion: Nov 200536 patients
Phase 1/2Terminated

Phase I/II Study of Pentostatin Combined With Tacrolimus and Mini-Methotrexate for GVHD Prevention After MUD BMT

Start: Sep 2000Est. completion: Nov 2009150 patients
Phase 1/2Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.