Zambon
Italy - Bresso
BiotechnologyFocus: Small Molecules
Zambon is a life sciences company focused on Small Molecules.
OphthalmologyCardiovascular
Open Jobs
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Products & Portfolio (4)
DORZOLAMIDE HYDROCHLORIDE
dorzolamide hydrochloride
Post-LOE
OPHTHALMIC · SOLUTION/DROPS
components: Dorzolamide hydrochloride and timolol maleate. Each of these two components decreases elevated intraocular pressure, whether or not associated with glaucoma, by reducing aqueous humor secretion. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss. The higher the level of intraocular pressure, the greater the likelihood of glaucomatous field loss and optic nerve damage. Dorzolamide hydrochloride is an inhibitor of human carbonic anhydrase II. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. Timolol maleate is a beta1 and beta2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. The combined effect of these two agents administered as dorzolamide hydrochloride and timolol maleate ophthalmic solution twice daily results in additional intraocular pressure reduction compared to either component administered alone, but the reduction is not as much as when dorzolamide administered three times daily and timolol twice daily are administered concomitantly. [See Clinical Studies ()].
elevated intraocular pressure (IOP) in patients with open-angle glaucomaocular hypertensionhypertension+1 more
2013
30
DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE
dorzolamide hydrochloride; timolol maleate
Post-LOE
OPHTHALMIC · SOLUTION/DROPS
components: dorzolamide hydrochloride and timolol maleate. Each of these two components decreases elevated intraocular pressure, whether or not associated with glaucoma, by reducing aqueous humor secretion. Elevated intraocular pressure is a major risk factor in the pathogenesis of optic nerve damage and glaucomatous visual field loss. The higher the level of intraocular pressure, the greater the likelihood of glaucomatous field loss and optic nerve damage. Dorzolamide hydrochloride is an inhibitor of human carbonic anhydrase II. Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. Timolol maleate is a beta 1 and beta 2 (non-selective) adrenergic receptor blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. The combined effect of these two agents administered as dorzolamide hydrochloride and timolol maleate ophthalmic solution twice daily results in additional intraocular pressure reduction compared to either component administered alone, but the reduction is not as much as when dorzolamide administered three times daily and timolol twice daily are administered concomitantly [see Clinical Studies ()].
elevated intraocular pressure (IOP) in patients with open-angle glaucomaocular hypertensionhypertension+1 more
2013
30
MONUROL
fosfomycin tromethamine
LOE Approaching
ORAL · FOR SOLUTION
1996
30
OLOPATADINE HYDROCHLORIDE
olopatadine hydrochloride
Post-LOE
OPHTHALMIC · SOLUTION/DROPS
2015
30
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Interview Prep Quick Facts
Founded: 1906
Portfolio: 4 approved products
Top TAs: Cardiovascular, Ophthalmology
Portfolio Health
LOE Approaching1 (25%)
Post-LOE3 (75%)
4 total products