Burns

16
Pipeline Programs
15
Companies
35
Clinical Trials
1 recruiting
5
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
4
1
2
6
Early DiscoveryClinical DevelopmentMarket

On Market (5)

Approved therapies currently available

Pfizer
GENOTROPINApproved
somatropin
Pfizer
injection1995
Pfizer
GENOTROPIN PRESERVATIVE FREEApproved
somatropin
Pfizer
injection1995
U
SAIZENApproved
somatropin
Unknown Company
injection1996
U
SEROSTIMApproved
somatropin
Unknown Company
injection1996
U
SEROSTIM LQApproved
somatropin
Unknown Company
subcutaneous1996

Competitive Landscape

14 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
2 programs
1
1
1
SomatropinPhase 2/35 trials
linezolidPhase 11 trial
Active Trials
NCT00255996Completed16Est. Jan 2007
NCT04697381Completed33Est. Apr 2024
NCT03038594Completed13Est. Nov 2021
+3 more trials
Fresenius Kabi
Fresenius KabiGermany - Bad Homburg
1 program
1
VolulytePhase 41 trial
Active Trials
NCT01689506Terminated11Est. Sep 2013
Cutiss
CutissSwitzerland - Schlieren
3 programs
2
1
denovoSkinPhase 31 trial
EHSG-KFPhase 21 trial
EHSG-KFPhase 21 trial
Active Trials
NCT03229564Active Not RecruitingEst. Jun 2028
NCT03227146Active Not RecruitingEst. Dec 2025
NCT06745557RecruitingEst. Jun 2028
AP
Amryt PharmaUK - London
1 program
1
Oleogel-S10 ointmentPhase 31 trial
Active Trials
NCT01657292Completed61Est. Jul 2014
KB
Kuros BiosciencesSwitzerland - Schlieren
1 program
1
I-020502Phase 21 trial
Active Trials
NCT00471939CompletedEst. Jan 2009
J&
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
1
R-Pdf/Gbb 0.01% gelPhase 21 trial
Active Trials
NCT00812513Unknown120Est. Apr 2012
NT
NeoMatrix TherapeuticsNY - Stony Brook
1 program
1
cNP8Phase 11 trial
Active Trials
NCT06223009Completed32Est. Jul 2024
United Therapeutics
United TherapeuticsMD - Silver Spring
1 program
1
cNP8Phase 1
AVITA Medical
AVITA MedicalCA - Valencia
5 programs
RESN/A1 trial
ReCellN/A1 trial
ReCell TreatmentN/A1 trial
ReCell and Split-thickness skin graftN/A1 trial
ReCell® Autologous Cell Harvesting DeviceN/A1 trial
Active Trials
NCT03626701Terminated19Est. Jun 2022
NCT02994654Completed12Est. Sep 2018
NCT02380612Completed30Est. Feb 2017
+2 more trials
Carbon Biosciences
Carbon BiosciencesMA - Waltham
2 programs
BCT Antimicrobial DressingN/A1 trial
FlamazineN/A1 trial
Active Trials
NCT01598493CompletedEst. Mar 2014
NCT01598480CompletedEst. Mar 2014
PolyNovo
PolyNovoAustralia - Port Melbourne
2 programs
Biodegradable Temporizing MatrixN/A1 trial
NovoSorb BTMN/A1 trial
Active Trials
NCT02905435Completed15Est. Sep 2019
NCT04090424Active Not Recruiting150Est. Dec 2026
Arrowhead Pharmaceuticals
1 program
Difference in development of Acute Lung Injury in Amphetamine positive and negative patientsN/A1 trial
Active Trials
NCT05611385Completed49Est. Jan 2020
Kerecis
KerecisIceland - Isafjordur
1 program
Fish skinN/A1 trial
Active Trials
NCT03984331CompletedEst. Sep 2021
Bristol Myers Squibb
1 program
Fluid Shifts During Resuscitation: Impacts on Macrocirculation and MicrocirculationN/A1 trial
Active Trials
NCT00326729Unknown40

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Fresenius KabiVolulyte
PfizerSomatropin
PfizerSomatropin
PfizerSomatropin
CutissdenovoSkin
PfizerSomatropin
Amryt PharmaOleogel-S10 ointment
PfizerSomatropin
PfizerSomatropin
PfizerSomatropin
PfizerSomatropin
PfizerSomatropin
PfizerSomatropin
PfizerSomatropin
PfizerSomatropin

Showing 15 of 35 trials with date data

Clinical Trials (35)

Total enrollment: 2,606 patients across 35 trials

Fluid Resuscitation in Patients Suffering From Burns Injury

Start: Dec 2012Est. completion: Sep 201311 patients
Phase 4Terminated

Treatment Of Adult Growth Hormone Deficiency After Traumatic Brain Injury.

Start: Apr 20070
Phase 4Withdrawn

A Study to Evaluate the Efficacy of Somatropin in Adults With Growth Hormone Deficiency Caused by Trauma and/or Head Injury

Start: Nov 2002Est. completion: Nov 2003100 patients
Phase 4Terminated

Long Term Study of Genotropin (Somatropin) for Short Children Born Small for Gestational Age (SGA)

Start: Oct 2002Est. completion: Aug 201562 patients
Phase 4Completed

Phase III Study with an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Adults and Adolescents

Start: Dec 2024Est. completion: Jun 2028
Phase 3Recruiting

Study of the Efficacy and Safety of Somatropin in Japanese Participants With PWS

Start: Feb 2021Est. completion: Apr 202433 patients
Phase 3Completed
NCT01657292Amryt PharmaOleogel-S10 ointment

Oleogel-S10 Versus Standard of Care in Healing of Grade 2a Burn Wounds

Start: Aug 2012Est. completion: Jul 201461 patients
Phase 3Completed

Neuromuscular Changes In Small For Gestational Age Children During Somatropin Therapy

Start: Jul 2008Est. completion: Mar 201123 patients
Phase 3Terminated

Genotropin Treatment In Very Young Children Born Small For Gestational Age

Start: Feb 2008Est. completion: Dec 201343 patients
Phase 3Completed

Evolution Of Growth Rate In Children With Growth Retardation Due to Glucocorticosteroid Therapy And Treated By Genotonorm

Start: Jan 2005Est. completion: Dec 201498 patients
Phase 3Completed

Growth Retardation In Children With Special Pathological Conditions Or Disease

Start: Jan 2005Est. completion: Oct 201146 patients
Phase 3Completed

Treatment With Recombinant Human Growth Hormone (GH) in Children With Short Stature Secondary to a Long Term Corticoid Therapy

Start: Sep 2000Est. completion: Sep 201130 patients
Phase 3Terminated

Treatment With Recombinant Human Growth Hormone Genotonorm (Registered) In Children With Short Stature Secondary

Start: Feb 1997Est. completion: Oct 200614 patients
Phase 3Completed

Growth Hormone Therapy for Muscle Regeneration in Severely Burned Patients

Start: Nov 2015Est. completion: Nov 202113 patients
Phase 2/3Completed

Growth Hormone in Children With Juvenile Rheumatoid Arthritis (JRA) and With Crohn's Disease

Start: Aug 2007Est. completion: May 201010 patients
Phase 2/3Terminated

Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Adults and Adolescents

Start: Oct 2017Est. completion: Dec 2025
Phase 2Active Not Recruiting

Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Children

Start: Oct 2017Est. completion: Jun 2028
Phase 2Active Not Recruiting
NCT00812513Johnson & JohnsonR-Pdf/Gbb 0.01% gel

Efficacy of R-Pdf/Gbb in Healing Wounds Caused by Third Degree Thermal and Electrical Burns

Start: Jul 2011Est. completion: Apr 2012120 patients
Phase 2Unknown

Safety and Efficacy of I-020502 in Meshed Skin Autografting

Start: Apr 2007Est. completion: Jan 2009
Phase 2Completed

Phase 1 Healthy Volunteer Burn Therapy Study

Start: Jan 2024Est. completion: Jul 202432 patients
Phase 1Completed

Evaluation Of Linezolid Pk Profile In Burns Patients

Start: May 2006Est. completion: Jan 200716 patients
Phase 1Completed

Assessment of Safety and Effectiveness of NovoSorb® BTM in Severe Burns

Start: Sep 2021Est. completion: Dec 2026150 patients
N/AActive Not Recruiting

RES® Prepared With RECELL® Compared to Standard of Care Dressings of Partial-thickness Burns in Ages 1-16 Years

Start: Mar 2020Est. completion: Jun 202219 patients
N/ATerminated

Fish Skin Compared to Cadaver Skin as Temporary Cover for Full Thickness Burns

Start: Feb 2019Est. completion: Sep 2021
N/ACompleted
NCT05611385Arrowhead PharmaceuticalsDifference in development of Acute Lung Injury in Amphetamine positive and negative patients

Amphetamine Induced Adult Respiratory Distress Syndrome

Start: Jan 2019Est. completion: Jan 202049 patients
N/ACompleted
NCT03333941AVITA MedicalReCell® Autologous Cell Harvesting Device

Continued Access to the Recell® Device for Treatment of Acute Burn Injuries

Start: Oct 2017Est. completion: May 201976 patients
N/ACompleted
NCT02905435PolyNovoBiodegradable Temporizing Matrix

Assessment of Safety and Effectiveness of Biodegradable Temporizing Matrix in the Treatment of Deep Burn Skin Injuries

Start: Nov 2016Est. completion: Sep 201915 patients
N/ACompleted

CONTINUED ACCESS PROTOCOL: Demonstration of the Safety and Effectiveness of ReCell® Combined With Meshed Skin Graft for Reduction of Donor Area in the Treatment of Acute Burn Injuries

Start: Oct 2016Est. completion: Sep 201812 patients
N/ACompleted
NCT02380612AVITA MedicalReCell Treatment

ReCell® Combined With Meshed Skin Graft in the Treatment of Acute Burn Injuries

Start: Jan 2015Est. completion: Feb 201730 patients
N/ACompleted

Special Investigation Of Genotropin Long Follow-Up For Patients With A Small For Gestational Age "Scoped for Japanese"

Start: Sep 2013Est. completion: Jun 2017482 patients
N/ACompleted
NCT01598493Carbon BiosciencesBCT Antimicrobial Dressing

To Study the Healing Effect of Silver Impregnated Activated Carbon Fiber Wound Dressing on Deep Dermal Burn

Start: May 2012Est. completion: Mar 2014
N/ACompleted

To Study the Healing Effect of Silver Impregnated Activated Carbon Fiber Wound Dressing on Superficial Dermal Burn

Start: May 2012Est. completion: Mar 2014
N/ACompleted
NCT01138917AVITA MedicalReCell and Split-thickness skin graft

A Multicenter Comparative Study of the ReCell Device and Autologous Split-thickness Meshed Skin Graft in the Treatment of Acute Burn Injuries

Start: May 2010Est. completion: Aug 2015101 patients
N/ACompleted

Long Term Use of Somatropin in Patients Small for Gestational Age

Start: Feb 2009Est. completion: Dec 2012920 patients
N/ACompleted
NCT00326729Bristol Myers SquibbFluid Shifts During Resuscitation: Impacts on Macrocirculation and Microcirculation

Fluid Shifts During Resuscitation: Impacts on Macrocirculation and Microcirculation

Start: May 200640 patients
N/AUnknown

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 2,606 patients
15 companies competing in this space