Skip to main content

Burns

21
Pipeline Programs
30
Companies
50
Clinical Trials
2 recruiting
3
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
5
4
1
1
2
8
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 47 programs with unclassified modality

On Market (3)

Approved therapies currently available

Pfizer
GENOTROPINApproved
somatropin
Pfizer
injection1995
27M Part D
Bayer
CIPROApproved
ciprofloxacin
Bayer
oral1997
396K Part D
Pfizer
GENOTROPIN PRESERVATIVE FREEApproved
somatropin
Pfizer
injection1995

Competitive Landscape

37 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
2 programs
1
1
1
SomatropinPhase 2/31 trial
linezolidPhase 14 trials
Active Trials
NCT01356472Unknown60
NCT01363271Completed7,260Est. May 2012
NCT00255996Completed16Est. Jan 2007
+2 more trials
Bayer
BayerLEVERKUSEN, Germany
1 program
1
1
CiprofloxacinPhase 3Small Molecule1 trial
Active Trials
NCT00668044Completed18Est. Nov 2003
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
Ceftolozane/tazobactamPhase 4
MSD
MSDIreland - Ballydine
1 program
1
Ceftolozane/tazobactamPhase 41 trial
Active Trials
NCT03002506Terminated6Est. Jun 2020
Cerus
CerusCA - Concord
1 program
1
Pathogen-Reduced PlasmaPhase 41 trial
Active Trials
NCT04681638Terminated13Est. Sep 2024
AVITA Medical
AVITA MedicalCA - Valencia
1 program
1
RECELLPhase 45 trials
Active Trials
NCT05971381Completed109Est. Jan 2025
NCT05386368Terminated1Est. May 2024
NCT04271501Terminated5Est. Aug 2021
+2 more trials
CellTherX
1 program
1
Split thickness skin graftPhase 41 trial
Active Trials
NCT04589442Recruiting20Est. Dec 2021
Cumberland Pharmaceuticals
1
CaldolorPhase 31 trial
Active Trials
NCT00606489Completed61Est. May 2009
Baxter
BaxterCosta Rica - Cartago
1 program
1
I-020502Phase 2
Biocorp
3 programs
1
human umbilical cord mesenchymal stem cellsPhase 1/21 trial
BCT Antimicrobial DressingN/A1 trial
FlamazineN/A1 trial
Active Trials
NCT01598493Completed30Est. Mar 2014
NCT01598480Completed30Est. Mar 2014
NCT01443689Unknown20Est. Jul 2013
Vomaris Innovations
1
ProcelleraPhase 1/21 trial
Active Trials
NCT01061502Completed17Est. Nov 2010
Noveome Biotherapeutics
1 program
1
ST266Phase 1/2
BioTherapeutics Inc
BioTherapeutics IncVA - Blacksburg
1 program
1
ST266Phase 1/21 trial
Active Trials
NCT00886470Terminated16Est. Mar 2010
Aegle Therapeutics
1 program
1
AGLE-102Phase 11 trial
Active Trials
NCT05078385Completed1Est. Nov 2024
Innovation Pharmaceuticals
1 program
1
Integra®Phase 11 trial
Active Trials
NCT05344521Not Yet Recruiting29Est. Feb 2027
ViiV Healthcare
ViiV HealthcareNC - Durham
1 program
1
Lactulose and Mannitol solutionPhase 1
Neomatrix
NeomatrixItaly - Rome
1 program
1
cNP8Phase 1
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
3 programs
Fresh Frozen PlasmaN/A1 trial
Suprathel or Xeroform donor site applicationN/A1 trial
triple antibiotic ointment dressingN/A1 trial
Active Trials
NCT05069922Completed59Est. Aug 2025
NCT04014400Terminated10Est. Jul 2020
NCT02681757Completed96Est. Sep 2017
Cutiss
3 programs
EHSG-KFPHASE_21 trial
EHSG-KFPHASE_21 trial
denovoSkinPHASE_31 trial
Active Trials
NCT03227146Active Not Recruiting14Est. Dec 2025
NCT03229564Active Not Recruiting12Est. Jun 2028
NCT06745557Recruiting70Est. Jun 2028
Carbon Biosciences
Carbon BiosciencesMA - Waltham
2 programs
BCT Antimicrobial DressingN/A
FlamazineN/A
PolyNovo
PolyNovoAustralia - Port Melbourne
2 programs
Biodegradable Temporizing MatrixN/A
NovoSorb BTMN/A1 trial
Active Trials
NCT04090424Active Not Recruiting150Est. Dec 2026
Human BioSciences
Human BioSciencesWV - Martinsburg
2 programs
Biodegradable Temporizing MatrixN/A1 trial
Face-to-face burn careN/A1 trial
Active Trials
NCT02905435Completed15Est. Sep 2019
NCT05019144Completed130Est. Mar 2024
MTI
MTIUT - Salt Lake City
2 programs
Proprioceptive neuromuscular facilitationN/A1 trial
Russian current and muscle energy techniquesN/A1 trial
Active Trials
NCT07183943Completed150Est. Jan 2026
NCT07174232Completed100Est. Jan 2026
Arrowhead Pharmaceuticals
1 program
Difference in development of Acute Lung Injury in Amphetamine positive and negative patientsN/A1 trial
Active Trials
NCT05611385Completed49Est. Jan 2020
Kerecis
1 program
Fish skinN/A1 trial
Active Trials
NCT03984331Completed5Est. Sep 2021
Bristol Myers Squibb
1 program
Fluid Shifts During Resuscitation: Impacts on Macrocirculation and MicrocirculationN/A1 trial
Active Trials
NCT00326729Unknown40
Medtronic
MedtronicNJ - Phillipsburg
1 program
Kerlix AMD gauzeN/A1 trial
Active Trials
NCT00656708Completed108Est. Jan 2011
Integra LifeSciences
MEDIHONEY® GEL WITH ACTIVE LEPTOSPERMUM HONEYN/A1 trial
Active Trials
NCT02250183Terminated21Est. Aug 2016
Zimmer Biomet
Zimmer BiometFL - Jacksonville
1 program
With PRPN/A1 trial
Active Trials
NCT00858442Completed44Est. Nov 2012
Martin Pharmaceuticals
1 program
virtual realityN/A1 trial
Active Trials
NCT06596837Completed71Est. Aug 2023

+7 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
AVITA MedicalRECELL
CerusPathogen-Reduced Plasma
CellTherXSplit thickness skin graft
MSDCeftolozane/tazobactam
AVITA MedicalRECELL
AVITA MedicalRECELL
Fresenius KabiVolulyte
Pfizerlinezolid
CutissdenovoSkin
Cumberland PharmaceuticalsCaldolor
BayerCiprofloxacin
Pfizerlinezolid
PfizerSomatropin
CutissEHSG-KF
CutissEHSG-KF

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 2,160 patients across 50 trials

RECELL to Promote Healing Following Carbon Dioxide (CO2) Laser Treatment in Cosmetic Patients

Start: Mar 2023Est. completion: May 20241 patients
Phase 4Terminated
NCT04681638CerusPathogen-Reduced Plasma

Plasma Resuscitation Without Lung Injury

Start: Aug 2022Est. completion: Sep 202413 patients
Phase 4Terminated
NCT04589442CellTherXSplit thickness skin graft

Microsurfaced Grafts in Deep Burn Wounds

Start: Jan 2021Est. completion: Dec 202120 patients
Phase 4Recruiting
NCT03002506MSDCeftolozane/tazobactam

Pharmacokinetics of Ceftolozane/Tazobactam in Patients With Burns

Start: Aug 2017Est. completion: Jun 20206 patients
Phase 4Terminated

Autologous Cell Suspension Grafting Using ReCell in Vitiligo and Piebaldism Patients

Start: May 2015Est. completion: Jan 201610 patients
Phase 4Completed

A Pilot Trial of the Use of ReCell® Autologous Cell Harvesting Device for Venous Leg Ulcers

Start: Jan 2013Est. completion: Oct 201552 patients
Phase 4Completed

Fluid Resuscitation in Patients Suffering From Burns Injury

Start: Dec 2012Est. completion: Sep 201311 patients
Phase 4Terminated

Linezolid Alone or Combined With Carbapenem Against Methicillin-resistant Staphylococcus Aureus (MRSA) in Ventilator-associated Pneumonia

Start: Jun 201160 patients
Phase 4Unknown

Phase III Study with an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Adults and Adolescents

Start: Dec 2024Est. completion: Jun 202870 patients
Phase 3Recruiting

Efficacy and Safety Study of Caldolor (Intravenous Ibuprofen) in Hospitalized Adult and Pediatric Burn Patients

Start: Nov 2007Est. completion: May 200961 patients
Phase 3Completed
NCT00668044BayerCiprofloxacin

Ciprofloxacin on Burned Patients

Start: Nov 2002Est. completion: Nov 200318 patients
Phase 3Completed

Treatment of Neutropenic Patients With Fever Who Are Suspected to Have A Gram Positive Infection

Start: Nov 2001Est. completion: Nov 2002120 patients
Phase 3Completed

Growth Hormone Therapy for Muscle Regeneration in Severely Burned Patients

Start: Nov 2015Est. completion: Nov 202113 patients
Phase 2/3Completed

Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Children

Start: Oct 2017Est. completion: Jun 202812 patients
Phase 2Active Not Recruiting

Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Adults and Adolescents

Start: Oct 2017Est. completion: Dec 202514 patients
Phase 2Active Not Recruiting
NCT00812513Johnson & JohnsonR-Pdf/Gbb 0.01% gel

Efficacy of R-Pdf/Gbb in Healing Wounds Caused by Third Degree Thermal and Electrical Burns

Start: Jul 2011Est. completion: Apr 2012120 patients
Phase 2Unknown

Safety and Efficacy of I-020502 in Meshed Skin Autografting

Start: Apr 2007Est. completion: Jan 200910 patients
Phase 2Completed
NCT01443689Biocorphuman umbilical cord mesenchymal stem cells

Allogenic Stem Cell Therapy in Patients With Acute Burn

Start: Jul 2011Est. completion: Jul 201320 patients
Phase 1/2Unknown

Efficacy Study of a Bioelectric Dressing to Treat Skin Graft Donor Site Wounds

Start: Sep 2009Est. completion: Nov 201017 patients
Phase 1/2Completed

ST266 Versus Standard Care In Treating Partial Thickness Burns

Start: Jun 2009Est. completion: Mar 201016 patients
Phase 1/2Terminated
NCT00161759Baxter InternationalSheet skin grafts affixed with Fibrin Sealant

Safety and Efficacy Study of Fibrin Sealant (FS 4IU) for Skin Graft Fixation and Wound Healing in Subjects With Burn Wounds

Start: Mar 2002Est. completion: Jan 200440 patients
Phase 1/2Completed

A Phase I, Single-blind, Randomized Study of the Safety and Efficacy of Cellularized Integra® Using Autologous Burn-derived Stem Cells

Start: Feb 2024Est. completion: Feb 202729 patients
Phase 1Not Yet Recruiting

Phase 1 Healthy Volunteer Burn Therapy Study

Start: Jan 2024Est. completion: Jul 202432 patients
Phase 1Completed

Safety of Extracellular Vesicles for Burn Wounds

Start: Aug 2023Est. completion: Nov 20241 patients
Phase 1Completed
NCT03242434GSKLactulose and Mannitol solution

Investigation of Thermal Injury on Intestinal Permeability in Both Thermal Injury and Healthy Participants

Start: Jan 2018Est. completion: Mar 201818 patients
Phase 1Terminated

Evaluation Of Linezolid Pk Profile In Burns Patients

Start: May 2006Est. completion: Jan 200716 patients
Phase 1Completed
NCT07183943MTIProprioceptive neuromuscular facilitation

VR Gaming Based PNF on Spatiotemporal Parameters in Upper Limb Burned Patients

Start: Oct 2025Est. completion: Jan 2026150 patients
N/ACompleted
NCT07174232MTIRussian current and muscle energy techniques

Russian Current and Muscle Energy Techniques on Circumferential Upper Arm Burn

Start: Oct 2025Est. completion: Jan 2026100 patients
N/ACompleted

Repigmentation of Stable Vitiligo Lesions Using Spray-On Skin™ Cells

Start: Aug 2023Est. completion: Jan 2025109 patients
N/ACompleted
NCT05019144Human BioSciencesFace-to-face burn care

Telemedicine Optimized Burn Intervention

Start: Jun 2022Est. completion: Mar 2024130 patients
N/ACompleted

Randomized Trial of Fresh Frozen Plasma Versus Albumin in Acute Burn Resuscitation

Start: Feb 2022Est. completion: Aug 202559 patients
N/ACompleted

Assessment of Safety and Effectiveness of NovoSorb® BTM in Severe Burns

Start: Sep 2021Est. completion: Dec 2026150 patients
N/AActive Not Recruiting

Virtual Reality and Coping with Procedural Pain in Burn Patients

Start: Sep 2021Est. completion: Aug 202371 patients
N/ACompleted

Feasibility Study to Evaluate RECELL and Melanocyte Keratinocyte Transplantation Procedure for Repigmentation of Stable Vitiligo Lesions

Start: Sep 2020Est. completion: Aug 20215 patients
N/ATerminated

Clinical Study to Investigate the Safety and Effectiveness of RECELL for Repigmentation of Stable Vitiligo Lesions

Start: Sep 2020Est. completion: Jan 202325 patients
N/ACompleted

RES® Prepared With RECELL® Compared to Standard of Care Dressings of Partial-thickness Burns in Ages 1-16 Years

Start: Mar 2020Est. completion: Jun 202219 patients
N/ATerminated

RECELL® System Combined With Meshed Autograft for Reduction of Donor Skin Harvesting in Soft Tissue Reconstruction

Start: Mar 2020Est. completion: Feb 202365 patients
N/ACompleted
NCT04014400Colorado TherapeuticsSuprathel or Xeroform donor site application

Suprathel Versus Xeroform for the Management of Skin Graft Donor Sites

Start: Jul 2019Est. completion: Jul 202010 patients
N/ATerminated

Fish Skin Compared to Cadaver Skin as Temporary Cover for Full Thickness Burns

Start: Feb 2019Est. completion: Sep 20215 patients
N/ACompleted
NCT05611385Arrowhead PharmaceuticalsDifference in development of Acute Lung Injury in Amphetamine positive and negative patients

Amphetamine Induced Adult Respiratory Distress Syndrome

Start: Jan 2019Est. completion: Jan 202049 patients
N/ACompleted

RES Prepared With RECELL® Compared to Conventional Care for Healing of Donor Sites in Ages 1-16 Years

Start: Sep 2018Est. completion: Jan 20203 patients
N/ATerminated

Continued Access to the Recell® Device for Treatment of Acute Burn Injuries

Start: Oct 2017Est. completion: May 201976 patients
N/ACompleted
NCT02905435Human BioSciencesBiodegradable Temporizing Matrix

Assessment of Safety and Effectiveness of Biodegradable Temporizing Matrix in the Treatment of Deep Burn Skin Injuries

Start: Nov 2016Est. completion: Sep 201915 patients
N/ACompleted

CONTINUED ACCESS PROTOCOL: Demonstration of the Safety and Effectiveness of ReCell® Combined With Meshed Skin Graft for Reduction of Donor Area in the Treatment of Acute Burn Injuries

Start: Oct 2016Est. completion: Sep 201812 patients
N/ACompleted
NCT02681757Colorado Therapeuticstriple antibiotic ointment dressing

Comparison of Mepitel Ag vs Antibiotic Ointment Used With Soft Cast Technique for Treatment of Pediatric Burns

Start: Sep 2016Est. completion: Sep 201796 patients
N/ACompleted

ReCell® Combined With Meshed Skin Graft in the Treatment of Acute Burn Injuries

Start: Jan 2015Est. completion: Feb 201730 patients
N/ACompleted

Prospective Evaluation of the ReCell® Autologous Cell Harvesting Device For Specific Compassionate Use Cases

Start: May 2014Est. completion: Jun 2020100 patients
N/ACompleted
NCT02250183Integra LifeSciencesMEDIHONEY® GEL WITH ACTIVE LEPTOSPERMUM HONEY

Medihoney and Santyl for Burn Injuries

Start: Mar 2014Est. completion: Aug 201621 patients
N/ATerminated
NCT01598493BiocorpBCT Antimicrobial Dressing

To Study the Healing Effect of Silver Impregnated Activated Carbon Fiber Wound Dressing on Deep Dermal Burn

Start: May 2012Est. completion: Mar 201430 patients
N/ACompleted

To Study the Healing Effect of Silver Impregnated Activated Carbon Fiber Wound Dressing on Superficial Dermal Burn

Start: May 2012Est. completion: Mar 201430 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 2,160 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.