NDAORALTABLET
Approved
Dec 1991
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
11
Data completeness
3/8 — Basic
ZOLOFT (sertraline hydrochloride) by Viatris (2) is 12. First approved in 1991.
Drug data last refreshed 8h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Zoloft (sertraline hydrochloride) is an oral selective serotonin reuptake inhibitor (SSRI) approved in 1991 for depression, anxiety, OCD, PTSD, panic disorder, and other psychiatric conditions. It works by blocking neuronal reuptake of serotonin in the central nervous system, potentiating serotonergic activity with minimal effects on norepinephrine and dopamine receptors.
LOE Approaching
As a mature, off-patent product approaching loss of exclusivity, Zoloft represents a consolidation phase requiring focus on generic competition management and cost-efficiency rather than growth expansion.
Mechanism of Action
12.1 Mechanism of Action Sertraline potentiates serotonergic activity in the central nervous system through inhibition of neuronal reuptake of serotonin (5-HT). 12.2 Pharmacodynamics Studies at clinically relevant doses have demonstrated that sertraline blocks the uptake of serotonin into human…
Worked on ZOLOFT at Viatris (2)? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.