NDAORALTABLET
Approved
Dec 1991
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
ZOCOR (simvastatin) by Merck & Co. is hydroxymethylglutaryl-coa reductase inhibitors [moa]. First approved in 1991.
Drug data last refreshed 13h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ZOCOR (simvastatin) is an oral HMG-CoA reductase inhibitor (statin) approved in 1991 that lowers cholesterol by inhibiting hepatic cholesterol synthesis. It is used to reduce cardiovascular risk in patients with elevated LDL cholesterol and dyslipidemia. Simvastatin remains a foundational therapy in lipid management despite the emergence of newer statin classes.
$0.002BPart D
LOE ApproachingDeclining
Declining Part D spending and approaching loss of exclusivity signal a shrinking brand team and shift toward lifecycle extension or deprioritization strategies.
Mechanism of Action
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Pharmacologic Class:
HMG-CoA Reductase Inhibitor
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
A Study to Investigate the Effect of AZD5004 on Rosuvastatin, Atorvastatin, Simvastatin, Repaglinide and the Effect of Erythromycin on AZD5004 in Healthy Participants
Started May 2025
49 enrolled
Healthy Participants
Simvastatin Treatment to Improve Patient-reported Outcomes in Patients With Chronic Pancreatitis
Started Oct 2024
90 enrolled
Recurrent Acute PancreatitisChronic Pancreatitis
Bioequivalence Study of Simvastatin 40 mg Film-coated Tablets in Healthy Thai Volunteers
Started Aug 2024
46 enrolled
Healthy Volunteer
Effect of Repeated Oral Doses of Avacopan on the Pharmacokinetics (PK) of a Single Dose of Simvastatin
Started Jun 2022
32 enrolled
Healthy Volunteers
Drug-Drug Interaction Study to Investigate Effects of Voclosporin on Pharmacokinetics of Simvastatin
Started Jan 2022
24 enrolled
Drug-drug Interaction
Worked on ZOCOR at Merck & Co.? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.