TYSABRI

LOE ApproachingmAb

natalizumab

BLASINGLE-USEVIALPriority Review
Approved
Nov 2004
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20

Mechanism of Action

Integrin Receptor Antagonists

Pharmacologic Class:

Integrin Receptor Antagonist

Clinical Trials (5)

NCT05618301Phase 1Completed

Motixafortide and Natalizumab to Mobilize CD34+ Hematopoietic Stem Cells for Gene Therapies in Sickle Cell Disease (SCD)

Started Jul 2023
10 enrolled
Sickle Cell Disease
NCT05925049N/AActive Not Recruiting

A Study Utilising Data From European Union (EU) National Multiple Sclerosis (MS) Registries to Assess the Incidence of Anti-Natalizumab Antibody Among Participants Who Receive Subcutaneous Administration of Natalizumab for Treatment of Relapsing-remitting Multiple Sclerosis (RRMS)

Started Jun 2023
400 enrolled
Multiple Sclerosis
NCT05701423N/ATerminated

A Study of End of Dose Phenomena in Subcutaneous Natalizumab Treated Multiple Sclerosis (MS) Participants

Started Feb 2023
34 enrolled
Multiple Sclerosis
NCT05532163Phase 4Terminated

A Study to Investigate the Radiological Onset of Action After Treatment Initiation With Subcutaneous (SC) Natalizumab in Participants With Relapsing-Remitting Multiple Sclerosis (RRMS)

Started Jan 2023
1 enrolled
Multiple Sclerosis, Relapsing-Remitting
NCT05418010Phase 2Recruiting

Natalizumab for the Treatment of People With Inflammatory Demyelination Suggestive of Multiple Sclerosis, or Definite Multiple Sclerosis, at First Presentation (AttackMS)

Started Dec 2022
40 enrolled
Multiple SclerosisClinically Isolated Syndrome of Demyelination