NDAORALTABLET
Approved
Aug 1965
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
TRIAVIL 4-10 (amitriptyline hydrochloride; perphenazine) by PharmaIN is clinical pharmacology amitriptyline hydrochloride is an antidepressant with sedative effects. Approved for depression. First approved in 1965.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TRIAVIL 4-10 is a fixed-dose combination tablet containing amitriptyline hydrochloride (tricyclic antidepressant) and perphenazine (antipsychotic) indicated for depression. Amitriptyline works by inhibiting reuptake of norepinephrine and serotonin in adrenergic and serotonergic neurons, thereby prolonging neuronal activity and producing antidepressant effects.
LOE Approaching
As a vintage antidepressant approaching loss of exclusivity, the brand team is likely consolidating around managed care and generic transition strategies rather than expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY Amitriptyline hydrochloride is an antidepressant with sedative effects. Its mechanism of action in man is not known. It is not a monoamine oxidase inhibitor and it does not act primarily by stimulation of the central nervous system. Amitriptyline inhibits the membrane pump…
Indications (1)
Career Relevance
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.