NDAORALCAPSULE
Approved
Mar 1973
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
TOFRANIL-PM (imipramine pamoate) by Hikma is clinical pharmacology the mechanism of action of imipramine is not definitely known. Approved for depression. First approved in 1973.
Drug data last refreshed 8h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
TOFRANIL-PM is an oral tricyclic antidepressant (imipramine pamoate) approved in 1973 for depression treatment. It works by blocking norepinephrine reuptake at nerve endings, potentiating adrenergic synapses. The pamoate salt formulation provides sustained-release delivery in capsule form.
LOE Approaching
As a legacy tricyclic nearing loss of exclusivity with moderate competitive pressure (30%), brand team is likely focused on defending market share and transitioning assets.
Mechanism of Action
CLINICAL PHARMACOLOGY The mechanism of action of imipramine is not definitely known. However, it does not act primarily by stimulation of the central nervous system. The clinical effect is hypothesized as being due to potentiation of adrenergic synapses by blocking uptake of norepinephrine at nerve…
Indications (1)
Career Relevance
TOFRANIL-PM is a legacy brand with zero linked job openings, reflecting minimal growth headcount expansion. Career opportunities are limited to market-defense and managed-care roles focused on generic penetration and lifecycle extension.
Brand Manager
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.