NDAORALTABLET
Approved
Apr 2012
Lifecycle
Peak
Competitive Pressure
30/100
Clinical Trials
16
Data completeness
4/8 — Partial
STENDRA (avanafil) by Hetero is (no) in the corpus cavernosum during sexual stimulation. Approved for erectile dysfunction. First approved in 2012.
Drug data last refreshed 1w ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
STENDRA (avanafil) is an oral phosphodiesterase-5 (PDE-5) inhibitor approved for erectile dysfunction. It works by inhibiting PDE-5 in the corpus cavernosum, enhancing nitric oxide signaling and increasing cGMP to promote smooth muscle relaxation and penile blood flow during sexual stimulation. Avanafil demonstrates >100-fold selectivity for PDE-5 over PDE-6, reducing visual side effects compared to earlier-generation PDE-5 inhibitors.
Peak
Product is at peak lifecycle stage with moderate competitive pressure (30/100); team size likely stable but not expanding significantly.
Mechanism of Action
(NO) in the corpus cavernosum during sexual stimulation. NO then activates the enzyme guanylate cyclase, which results in increased levels of cGMP, producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. Avanafil has no direct relaxant effect on isolated human…
Indications (1)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.