Skip to main content

Erectile Dysfunction

127
Pipeline Programs
30
Companies
50
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
26
1
10
2
48
40
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
5100%
+ 169 programs with unclassified modality

On Market (1)

Approved therapies currently available

VARDENAFIL HYDROCHLORIDEApproved
vardenafil
Unknown Company
oral2018

Competitive Landscape

41 companies ranked by most advanced pipeline stage

Bayer
BayerLEVERKUSEN, Germany
49 programs
2
2
1
22
16
LevitraPhase 4
LevitraPhase 4
LevitraPhase 4
LevitraPhase 4
LevitraPhase 41 trial
+44 more programs
Active Trials
NCT00874679Completed7,293Est. Apr 2010
NCT00470873Completed2,471Est. Feb 2008
NCT01106118Completed2,289Est. Aug 2013
+29 more trials
ViiV Healthcare
ViiV HealthcareNC - Durham
18 programs
1
1
8
8
LEVITRAPhase 4
LevitraPhase 4
LevitraPhase 4
LevitraPhase 4
LevitraPhase 4
+13 more programs
Prevail Therapeutics
1
1
5
7
TadalafilPhase 41 trial
TadalafilPhase 41 trial
TadalafilPhase 41 trial
TadalafilPhase 41 trial
TadalafilPhase 41 trial
+9 more programs
Active Trials
NCT01401543Completed24Est. Sep 2011
NCT01160289Completed410Est. Nov 2011
NCT00855582Completed606Est. Jul 2010
+11 more trials
Pfizer
PfizerNEW YORK, NY
13 programs
4
1
1
4
sildenafilPhase 41 trial
sildenafilPhase 41 trial
sildenafilPhase 41 trial
tadalafilPhase 41 trial
delivery systemPhase 31 trial
+8 more programs
Active Trials
NCT00874185Completed720Est. May 2008
NCT00743613Completed175Est. May 2008
NCT01108900Completed100Est. Oct 2011
+14 more trials
VIVUS
VIVUSCA - Campbell
11 programs
9
1
1
avanafilPhase 41 trial
avanafilPhase 31 trial
200 mg AvanafilPhase 11 trial
OmeprazolePhase 1Small Molecule1 trial
RitonavirPhase 1Small Molecule1 trial
+6 more programs
Active Trials
NCT01095588Completed24Est. May 2010
NCT01415128Completed60Est. May 2010
NCT00770042Completed44Est. Dec 2008
+8 more trials
Hanmi Pharmaceutical
6 programs
4
1
1
TadalafilPhase 41 trial
HCP1302Phase 31 trial
HCP1303Phase 11 trial
HCP1303Phase 11 trial
HIP0908Phase 11 trial
+1 more programs
Active Trials
NCT02712411Completed30Est. Sep 2015
NCT02715401Completed36Est. Nov 2015
NCT01514903Completed54Est. Dec 2011
+3 more trials
Martin Pharmaceuticals
1 program
1
NebivololPhase 4Small Molecule1 trial
Active Trials
NCT01885988Unknown70Est. Jun 2014
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
1
Sildenafil citratePhase 41 trial
Active Trials
NCT00512707Completed140Est. May 2010
Futura Medical
Futura MedicalUK - Surrey
4 programs
1
1
2
MED2005Phase 31 trial
MED3000Phase 31 trial
Glyceryl trinitratePhase 21 trial
MED2005Phase 11 trial
Active Trials
NCT04008732Completed40Est. Apr 2018
NCT02495467Completed232Est. Jul 2016
NCT03813992Completed1,005Est. Jan 2020
+1 more trials
JW Pharmaceutical
2
AvanafilPhase 31 trial
Avanafil 100 or 200mgPhase 31 trial
Active Trials
NCT00903981Completed208Est. Nov 2009
NCT01705197Completed195Est. Nov 2013
Dong-A ST
2 programs
2
DA-8159Phase 31 trial
DA-8159Phase 31 trial
Active Trials
NCT01901640Completed302Est. Nov 2012
NCT01774864Completed349Est. May 2012
EMS
2 programs
2
Tanzânia associationPhase 31 trial
Toronto associationPhase 31 trial
Active Trials
NCT04185441Completed295Est. Jul 2024
NCT05052879Not Yet Recruiting232Est. Aug 2026
Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
LevitraPhase 3
Abdi Ibrahim
1 program
1
udenafilPhase 31 trial
Active Trials
NCT01305083Completed118Est. Aug 2011
Dicot
2 programs
1
1
LIB-01Phase 21 trial
LIB-01Phase 11 trial
Active Trials
NCT06324006Completed64Est. May 2024
NCT06703840Completed156Est. Aug 2025
Medica Corp
Medica CorpMA - Bedford
2 programs
1
1
TPN171HPhase 21 trial
TPN171HPhase 11 trial
Active Trials
NCT05185011Completed24Est. Feb 2022
NCT04479917Completed255Est. Jul 2021
Initiator Pharma
Initiator PharmaDenmark - Copenhagen
2 programs
2
IP2018Phase 21 trial
IPED2015Phase 21 trial
Active Trials
NCT04686916Unknown24Est. Aug 2023
NCT04969666Unknown120Est. Nov 2022
Channel Therapeutics
Channel TherapeuticsNJ - North Brunswick
1 program
1
hMaxi-K Single Treatment/ 2 escalating dose levelsPhase 21 trial
Active Trials
NCT02713789Completed26Est. Aug 2017
Tritech Biopharmaceuticals
1 program
1
TR-399Phase 1/21 trial
Active Trials
NCT03102398Unknown26Est. Mar 2018
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
Vardenafil ODT,Phase 1
MSD
MSDIreland - Ballydine
1 program
1
Vardenafil ODT,Phase 11 trial
Active Trials
NCT01348880Completed42Est. Dec 2011
Vigonvita
VigonvitaChina - Suzhou
8 programs
TPN171HPHASE_11 trial
TPN171HPHASE_1
TPN171HPHASE_11 trial
TPN171H 10mgPHASE_11 trial
TPN171HPHASE_2
+3 more programs
Active Trials
NCT06090136Completed12Est. Jul 2022
NCT06090123Completed24Est. Sep 2020
NCT05585931Completed18Est. Dec 2022
+3 more trials
Boston Scientific
Boston ScientificCA - Valencia
3 programs
AMS Penile Prosthesis DevicesN/A1 trial
Registry for Patients Undergoing Penile Prosthesis Implantation for Male Erectile DysfunctionN/A1 trial
Tactra MalleableN/A1 trial
Active Trials
NCT01383018Completed1,457Est. Jul 2018
NCT03849586Active Not Recruiting1,076Est. Feb 2032
NCT04200937Enrolling By Invitation450Est. Dec 2031
Coloplast
ColoplastAustralia - Mulgrave
3 programs
Inflatable Penile ProsthesisN/A1 trial
Inflatable Penile ProsthesisN/A1 trial
Registry for Patients Undergoing Penile Prosthesis Implantation for Male Erectile DysfunctionN/A
Active Trials
NCT00731939Completed124Est. Apr 2010
NCT00731666Completed40Est. May 2011
GSK
GSKLONDON, United Kingdom
3 programs
LevitraPHASE_41 trial
LevitraPHASE_41 trial
LevitraPHASE_41 trial
Active Trials
NCT00662441Completed102Est. Jun 2004
NCT00681772Completed333Est. Nov 2003
NCT00663130Completed759Est. Jul 2004
Dornier MedTech
Dornier MedTechFrance - Sillingy
2 programs
Dornier Aries 2N/A1 trial
ARIESPHASE_11 trial
Active Trials
NCT03039218Terminated54Est. Mar 2018
NCT02620982Completed23Est. Sep 2016
Tissue Genesis
2 programs
Injection of adipose derived cells into penisN/A1 trial
Tissue Genesis Cell Isolation SystemN/A1 trial
Active Trials
NCT03518333Unknown60Est. Sep 2023
NCT01601353Unknown30Est. Aug 2021
Genesis Therapeutics
Genesis TherapeuticsCA - Burlingame
2 programs
Injection of adipose derived cells into penisN/A
Tissue Genesis Cell Isolation SystemN/A
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
2 programs
LY2452473PHASE_1
LY2452473PHASE_2
Sanofi
SanofiPARIS, France
2 programs
SAR407899PHASE_21 trial
Tadalafil 5 mg tablets with a digital tool.PHASE_31 trial
Active Trials
NCT00914277Completed24Est. Oct 2009
NCT06805513Recruiting2,250Est. Feb 2026

+11 more companies

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Hanmi PharmaceuticalTadalafil
Prevail TherapeuticsTadalafil
PfizerSildenafil
Martin PharmaceuticalsNebivolol
VIVUSavanafil
Prevail TherapeuticsTadalafil
Prevail TherapeuticsTadalafil
Prevail TherapeuticsTadalafil
Prevail TherapeuticsTadalafil
BayerVardenafil
PfizerSildenafil
PfizerSildenafil
BayerTestosterone Undecanoate and/or PDE-5
Human BioSciencesSildenafil citrate
PfizerSildenafil

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 48,318 patients across 50 trials

Effect of Tadalafil on Erectile Dysfunction Treatment and QOL Improvement Effect (by SF-12) in Andropause Patients With Erectile Dysfunction

Start: Jul 2016Est. completion: Jul 201740 patients
Phase 4Unknown

A Study of Tadalafil (LY450190) in Chinese Men With Erectile Dysfunction

Start: Oct 2014Est. completion: May 2017635 patients
Phase 4Completed

Effects of Oral Sildenafil on Mortality in Adults With PAH

Start: Sep 2014Est. completion: Feb 2021385 patients
Phase 4Terminated

Nebivolol Effects on Endothelial Function and Erectile Function

Start: Mar 2013Est. completion: Jun 201470 patients
Phase 4Unknown

Study Evaluating the Effects of Avanafil on Semen Parameters

Start: Dec 2012Est. completion: Aug 2014181 patients
Phase 4Completed

A Study of Tadalafil and Sildenafil in Men With Erectile Dysfunction in China

Start: Jun 2011Est. completion: Jul 2012383 patients
Phase 4Completed

A Study in Erectile Dysfunction

Start: Aug 2010Est. completion: Jan 2012623 patients
Phase 4Completed

A Study in Patients With Erectile Dysfunction

Start: May 2010Est. completion: Jun 2011770 patients
Phase 4Completed

A Study of Tadalafil After Radical Prostatectomy

Start: Nov 2009Est. completion: Oct 2012583 patients
Phase 4Completed

Study of Vardenafil in Patients Suffering From Erectile Dysfunction and Metabolic Syndrome

Start: Nov 2008Est. completion: Oct 2009150 patients
Phase 4Completed

To Assess The Efficacy and Safety Of Oral Sildenafil in the Treatment of Pulmonary Arterial Hypertension.

Start: Apr 2008Est. completion: May 2010130 patients
Phase 4Terminated

A Multicenter, Open Label, To Evaluate The Efficacy And Satisfaction Of Patrex® In Men With Erectile Dysfunction.

Start: Jun 2007Est. completion: Feb 2008117 patients
Phase 4Completed
NCT00555087BayerTestosterone Undecanoate and/or PDE-5

Treatment of Erectile Dysfunction in Hypogonadal Men With Testosterone Undecanoate

Start: May 2007Est. completion: Jan 200850 patients
Phase 4Unknown

Effect of Testosterone in Men With Erectile Dysfunction

Start: Nov 2006Est. completion: May 2010140 patients
Phase 4Completed

Study to Evaluate Viagra's Ability to Provide a Better Sexual Experience Through Quality Erections and Satisfaction

Start: Nov 2005Est. completion: Sep 2006312 patients
Phase 4Completed

Impact Of Viagra On Sexual Satisfaction Of Men With Mild Erectile Dysfunction Who Are Sexually Dissatisfied

Start: Nov 2005Est. completion: Sep 2007183 patients
Phase 4Completed

Effect of Sildenafil on Quality of Sexual Life in Mild to Normally Sexually Functioning Males

Start: Sep 2005Est. completion: Jun 2007100 patients
Phase 4Unknown

Study Of Men With Mild To Moderate Erectile Dysfunction To Evaluate The Efficacy Of Viagra 8 Hours Post-Dose

Start: Aug 2005Est. completion: May 2006250 patients
Phase 4Completed

Assess Efficacy in Subjects With Traumatic Spinal Cord Injury

Start: Jul 2005Est. completion: Feb 200745 patients
Phase 4Completed

A Study of Visual Effects of Erectile Dysfunction Medications Dosed Daily for Six Months

Start: Jun 2005Est. completion: Aug 2006198 patients
Phase 4Completed

Mild To Moderate Erectile Dysfunction Study

Start: Apr 2005Est. completion: Feb 2006355 patients
Phase 4Completed

To Yield Further Information On The Efficacy And Safety Of Viagra Among Subjects With Arterial Hypertension .

Start: Mar 2005Est. completion: Nov 2005253 patients
Phase 4Completed

Assess the Effect of Daily Treatment of Vardenafil 20mg or Sildenafil 100mg and Placebo on Sperm Function

Start: Jan 2005Est. completion: Jun 2006200 patients
Phase 4Completed

A Randomised Study of Levitra to Treat Men With Erections Problems and Previously Untreated With Similar Therapy.

Start: May 2004Est. completion: Jan 2005260 patients
Phase 4Completed

Evaluation of LEVITRA to Advance the Treatment of Erectile Dysfunction

Start: May 2004Est. completion: Oct 20051,029 patients
Phase 4Completed

Evaluating the Efficacy Vardenafil 10 mg vs Tadalafil 10 mg in in Subjects With Erectile Dysfunction (ED)

Start: Apr 2004Est. completion: Jul 2004759 patients
Phase 4Completed

A Study of Semen Characteristics After 9 Months of Daily Tadalafil 20 mg

Start: Nov 2003Est. completion: Dec 2005282 patients
Phase 4Completed

Levitra® - Real Life Safety and Efficacy of Levitra

Start: Oct 2003Est. completion: Sep 200430,825 patients
Phase 4Completed

Evaluating of the Efficacy and Safety of Vardenafil in Subjects With Erectile Dysfunction

Start: Sep 2003Est. completion: Jun 2004102 patients
Phase 4Completed

A Randomized, Open-Label, Crossover, Multicenter, Single Dose Comparator Study Evaluating Onset Of Penile Rigidity In Men With Erectile Dysfunction Who Are Treated With Sildenafil And Tadalafil

Start: Jun 2003Est. completion: Nov 200356 patients
Phase 4Completed

A Study to Evaluate Self-esteem and Relationships in Males With Erectile Dysfuntion

Start: May 2003Est. completion: May 2004780 patients
Phase 4Completed

Assessment of Vardenafil in Patients With Erectile Dysfunction in Asia

Start: Mar 2003Est. completion: Apr 2004348 patients
Phase 4Completed

Evaluation of the Safety and Efficacy of Vardenafil in Subjects With Erectile Dysfunction

Start: Mar 2003Est. completion: Nov 2003333 patients
Phase 4Completed

Evaluation of Efficacy and Safety of Vardenafil in Patients With Erectile Dysfunction and Type 1 Diabetes

Start: Feb 2003Est. completion: Jan 2004318 patients
Phase 4Completed

A Multicenter, Double-blind Study to Evaluate the Effect of Pretreatment With a Daily Dose of Sildenafil on the As-Needed Efficacy of Viagra in Men With Erectile Dysfunction and Type 2 Diabetes

Start: Dec 2002Est. completion: Jan 2004300 patients
Phase 4Completed
NCT06805513SanofiTadalafil 5 mg tablets with a digital tool.

Actual Use Trial of Tadalafil 5 mg

Start: Jan 2025Est. completion: Feb 20262,250 patients
Phase 3Recruiting
NCT05052879EMSToronto association

Efficacy and Safety of Toronto Association in the Treatment of Erectile Dysfunction and Premature Ejaculation

Start: Jul 2024Est. completion: Aug 2026232 patients
Phase 3Not Yet Recruiting

Long-term Safety of TPN171H Tablet in Erectile Dysfunction.

Start: Apr 2024Est. completion: Jun 2025472 patients
Phase 3Completed
NCT05490680IBSA Institut BiochimiqueSildenafil Oral Film 25 mg, 50 mg, 75 mg or 100 mg

A New Sildenafil Oral Film in Patients With Erectile Dysfunction

Start: Jan 2024Est. completion: Dec 2024488 patients
Phase 3Completed
NCT06942988T-Therapeuticsintracavernous platelet rich plasma therapy

Efficacy of Intracavernous Platelet-rich Plasma Injection in the Treatment of Erectile Dysfunction

Start: Dec 2023Est. completion: Jul 2025
Phase 3Active Not Recruiting
NCT05188989VigonvitaTPN171H 2.5mg group

Efficacy and Safety Study of TPN171H Tablets in Erectile Dysfunction.

Start: Dec 2021Est. completion: Feb 2023765 patients
Phase 3Completed

Clinical Investigation Using MED3000 Gel or Tadalafil Tablets in the Treatment of Erectile Dysfunction

Start: Sep 2021Est. completion: Jul 2022116 patients
Phase 3Completed
NCT04185441EMSTanzânia association

Efficacy and Safety of Tanzânia Association in the Treatment of Erectile Dysfunction Associated With Benign Prostatic Hyperplasia

Start: Mar 2021Est. completion: Jul 2024295 patients
Phase 3Completed

Clinical Trial Using Topically Applied Glyceryl Trinitrate (GTN) for the Treatment of Erectile Dysfunction

Start: Nov 2018Est. completion: Jan 20201,005 patients
Phase 3Completed

Sildenafil for the Prevention of Right Heart Failure Following LVAD Implantation

Start: Mar 2018Est. completion: Jan 202224 patients
Phase 3Unknown

Trial to Evaluate the Efficacy and Safety of HCP1302

Start: Sep 2014Est. completion: Aug 2015232 patients
Phase 3Completed
NCT01705197JW PharmaceuticalAvanafil 100 or 200mg

This Study is to Evaluate the Safety and Efficacy of Avanafil in the Treatment of Erectile Dysfunction.

Start: Feb 2012Est. completion: Nov 2013195 patients
Phase 3Completed

Safety Study of Once-a-Day Dosing of Udenafil to Treat Erectile Dysfunction

Start: Nov 2011Est. completion: Nov 2012302 patients
Phase 3Completed

Efficacy and Safety Study of Udenafil to Treat Erectile Dysfunction

Start: Apr 2011Est. completion: May 2012349 patients
Phase 3Completed
NCT01008605Pfizerdelivery system

Caverject User Study

Start: Feb 2011Est. completion: Feb 201148 patients
Phase 3Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

48 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 48,318 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.