NDAORALTABLET
Approved
Sep 1961
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
RENESE (polythiazide) by Pfizer is clinical pharmacology polythiazide renese (polythiazide) alone has demonstrated clinical effectiveness in lowering elevated blood pressure in patients without visible edema as well as in edematous hypertensive patients. Approved for pregnancy, just. First approved in 1961.
Drug data last refreshed 11h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
RENESE (polythiazide) is an oral thiazide diuretic approved in 1961 that lowers elevated blood pressure by interfering with renal tubular electrolyte reabsorption. The fixed-dose combination with reserpine (RENESE-R) enhances efficacy through complementary mechanisms: polythiazide reduces sodium/fluid retention while reserpine depletes norepinephrine to lower vascular resistance and provide sedation. It is indicated for hypertension management in both edematous and non-edematous patients.
LOE Approaching
As a legacy product approaching loss of exclusivity, this brand is in managed-decline mode with minimal commercial investment and likely small, specialized teams focused on generic transition planning.
Mechanism of Action
CLINICAL PHARMACOLOGY Polythiazide Renese (polythiazide) alone has demonstrated clinical effectiveness in lowering elevated blood pressure in patients without visible edema as well as in edematous hypertensive patients. Its mechanism of action results in an interference with the renal tubular…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.