NDAINJECTIONINJECTABLE
Approved
May 1953
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
QUELICIN PRESERVATIVE FREE (succinylcholine chloride) by Pfizer is blocker. Approved for mechanical ventilation. First approved in 1953.
Drug data last refreshed 2d ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
QUELICIN PRESERVATIVE FREE is a depolarizing neuromuscular blocking agent containing succinylcholine chloride, approved since 1953 for facilitating mechanical ventilation during anesthesia. It works by mimicking acetylcholine at the motor end plate, causing initial depolarization (fasciculations) followed by sustained neuromuscular blockade with rapid onset (<1 minute) and short duration (4-6 minutes). The preservative-free formulation offers an alternative to standard preparations for patients with preservative sensitivities.
LOE Approaching
As a legacy anesthetic agent approaching loss of exclusivity with moderate competitive pressure (30/100), brand teams face declining commercial support and shrinking portfolios.
Mechanism of Action
blocker. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. This depolarization may be observed as fasciculations. Subsequent neuromuscular transmission is inhibited so long as adequate concentration of succinylcholine remains at the…
Indications (1)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.