PRETOMANID

Post-LOE

pretomanid

NDAORALTABLETPriority Review
Approved
Aug 2019
Lifecycle
Post-LOE
Competitive Pressure
35/100
Clinical Trials
5

Mechanism of Action

Organic Anion Transporter 3 Inhibitors

Pharmacologic Class:

Antimycobacterial

Clinical Trials (5)

NCT06058299Phase 2Active Not Recruiting

Phase 2 Trial Assessing TBAJ876 or Bedaquiline, with Pretomanid and Linezolid in Adults with Drug-sensitive Pulmonary Tuberculosis

Started Oct 2023
309 enrolled
Pulmonary TBPulmonary TuberculosisDrug Sensitive Tuberculosis
NCT05586230Phase 1Recruiting

Study of a Single Dose of Pretomanid Added to an Optimized Background Regimen in Children With Rifampicin-Resistant Tuberculosis

Started Oct 2023
72 enrolled
TuberculosisRifampicin Resistant Tuberculosis
NCT04179500Phase 2Completed

A Trial to Evaluate the Male Reproductive Safety of Pretomanid in Adult Male Participants With Drug Resistant Pulmonary Tuberculosis

Started Sep 2021
26 enrolled
Tuberculosis, PulmonaryTuberculosis, Multidrug-ResistantTuberculosis, MDR+2 more
NCT04309656Phase 1Completed

Single-dose Study in Two Panels of Healthy Adult Participants to Assess Immediate-Release and Dispersible Formulations of Pretomanid

Started Jan 2020
48 enrolled
Multi-drug Resistant Tuberculosis
NCT03086486Phase 3Completed

Various Doses and Durations of Linezolid Plus Bedaquiline & Pretomanid in Participants With Drug Resistant Tuberculosis

Started Nov 2017
181 enrolled
Tuberculosis, PulmonaryTuberculosis, Multidrug-ResistantTuberculosis, MDR+4 more

Loss of Exclusivity

LOE Date
Aug 14, 2024
19 months ago
Exclusivity Expiry
Aug 14, 2029