NDAINJECTIONINJECTABLE
Approved
Dec 1999
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
6
Data completeness
5/8 — Partial
Drug Shortage Active
PRECEDEX is currently in shortage. Reason: Available. This may impact manufacturing, supply chain, and quality hiring at the manufacturer.
PRECEDEX (dexmedetomidine hydrochloride) by Pfizer is 2 -adrenergic agonist with sedative properties. Approved for sedation, delirium, icu sedation. First approved in 1999.
Drug data last refreshed 21h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PRECEDEX is a 2-adrenergic agonist injectable sedative approved for ICU sedation, delirium management, and general sedation in hospitalized patients. It works by selectively binding alpha-2 adrenergic receptors at lower doses, providing anxiolytic and sedative effects with preserved airway reflexes. The drug has been a cornerstone of critical care anesthesia since its 1999 FDA approval.
Peak6.2 years to LOE
PRECEDEX is in peak commercial phase with established hospital formulary penetration, suggesting stable team size and mature market management.
Mechanism of Action
2 -adrenergic agonist with sedative properties. Alpha 2 selectivity is observed in animals following slow intravenous infusion of low and medium doses (10–300 mcg/kg). Both alpha 1 and alpha 2 activity is observed following slow intravenous infusion of high doses (≥1,000 mcg/kg) or with rapid…
Indications (3)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.