POMALYST

Peak

pomalidomide

NDAORALCAPSULEPriority Review
Approved
Feb 2013
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
20

Mechanism of Action

immunomodulatory, antiangiogenic, and antineoplastic properties. Cellular activities of pomalidomide are mediated through its target cereblon, a component of a cullin ring E3 ubiquitin ligase enzyme complex. In vitro, in the presence of drug, substrate proteins (including Aiolos and Ikaros) are…

Pharmacologic Class:

Thalidomide Analog

Clinical Trials (5)

NCT07138209Phase 3Recruiting

A Study Comparing QLS32015 Monotherapy Versus Pomalidomide, Dexamethasone (Pd) or Selinexor, Dexamethasone (Sd) in Participants With Relapsed or Refractory Multiple Myeloma

Started Nov 2025
228 enrolled
Relapsed or Refractory Multiple Myeloma
NCT06768489Phase 1Recruiting

A Study of JNJ-79635322 in Combination With Daratumumab With or Without Lenalidomide or in Combination With Pomalidomide for Multiple Myeloma

Started Dec 2024
140 enrolled
Multiple Myeloma
NCT06208150Phase 3Recruiting

A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide

Started Jan 2024
795 enrolled
Multiple Myeloma
NCT05730036Phase 3Recruiting

A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma

Started Sep 2023
410 enrolled
Relapsed Refractory Multiple Myeloma (RRMM)
NCT05789303Phase 2Recruiting

Study of Belantamab Mafodotin With Carfilzomib, Pomalidomide, and Dexamethasone in Relapsed Multiple Myeloma

Started May 2023
83 enrolled
Multiple MyelomaRelapse Multiple Myeloma

Loss of Exclusivity

LOE Date
Dec 21, 2031
70 months away
Patent Expiry
Dec 21, 2031
Exclusivity Expiry
Nov 14, 2027

Patent Records (5)

Patent #ExpiryTypeUse Code
10555939
May 19, 2030
Product
9993467
May 19, 2030
Product
10555939*PED
Nov 19, 2030
9993467*PED
Nov 19, 2030
8828427
Jun 21, 2031
SubstanceProduct