NDAINTRAVENOUSSOLUTION
Approved
May 2023
Lifecycle
Growth
Competitive Pressure
0/100
Clinical Trials
20
Data completeness
5/8 — Partial
PEMETREXED (pemetrexed disodium) by Medica Corp is folate-dependent metabolic processes essential for cell replication. Approved for non-small cell lung cancer, malignant mesothelioma, ovarian cancer and 1 more indications. First approved in 2023.
Drug data last refreshed 20h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Pemetrexed disodium is a folate antagonist chemotherapy agent that inhibits multiple folate-dependent enzymes (thymidylate synthase, dihydrofolate reductase, and GARFT) essential for nucleotide synthesis and cell replication. It is indicated for non-small cell lung cancer, malignant mesothelioma, ovarian cancer, and primary peritoneal cancer via intravenous infusion. The drug is converted to polyglutamate forms within cells, where it is retained and potentiates its anti-tumor effect.
Growth8.9 years to LOE
Early-stage growth trajectory with 8.9 years of patent protection remaining, indicating a mid-sized team focused on market expansion and indication development.
Mechanism of Action
folate-dependent metabolic processes essential for cell replication. In vitro studies show that pemetrexed inhibits thymidylate synthase (TS), dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase (GARFT), which are folate-dependent enzymes involved in the de novo biosynthesis…
Indications (4)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.