NDAORALTABLETPriority Review
Approved
Feb 1961
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
Priority Review
PARNATE (tranylcypromine sulfate) by PharmaIN is understood, but is presumed to be linked to potentiation of monoamine neurotransmitter activity in the central nervous system (cns) resulting from its irreversible inhibition of the enzyme monoamine oxidase (mao). Approved for major depressive disorder (mdd) in adult patients, drug interactions, the need for dietary restrictions (,. First approved in 1961.
Drug data last refreshed Yesterday · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PARNATE (tranylcypromine sulfate) is an oral monoamine oxidase (MAO) inhibitor approved in 1961 for major depressive disorder in adults. It works by irreversibly inhibiting MAO, thereby potentiating monoamine neurotransmitter activity in the central nervous system. The drug requires careful patient monitoring due to significant drug interactions and dietary restrictions.
$0.5MPart D
LOE ApproachingWith LOE approaching and minimal Part D activity ($508K in 2023), the brand team is small and focused on retention of a niche patient population.
Mechanism of Action
understood, but is presumed to be linked to potentiation of monoamine neurotransmitter activity in the central nervous system (CNS) resulting from its irreversible inhibition of the enzyme monoamine oxidase (MAO).
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.