NDAORALSOLUTION
Approved
Aug 1977
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
PAMELOR (nortriptyline hydrochloride) by ANI Pharmaceuticals is clinical pharmacology the mechanism of mood elevation by tricyclic antidepressants is at present unknown. Approved for depression. First approved in 1977.
Drug data last refreshed 10h ago · AI intelligence enriched 4w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PAMELOR (nortriptyline hydrochloride) is a tricyclic antidepressant approved in 1977 for the treatment of depression. It works by interfering with the transport, release, and storage of catecholamines, and inhibits the activity of histamine, serotonin, and acetylcholine. The exact mechanism of mood elevation remains unknown, but the drug exhibits a combination of stimulant and depressant properties.
$0.002BPart D
LOE ApproachingDeclining
Minimal commercial momentum with only $2M in Part D spending and 427 claims in 2023; brand team likely focused on generic transition management rather than growth initiatives.
Mechanism of Action
CLINICAL PHARMACOLOGY The mechanism of mood elevation by tricyclic antidepressants is at present unknown. Nortriptyline hydrochloride is not a monoamine oxidase inhibitor. It inhibits the activity of such diverse agents as histamine, 5-hydroxytryptamine, and acetylcholine. It increases the pressor…
Indications (1)
Career Relevance
Working on PAMELOR offers limited career advancement opportunities given the product's LOE Approaching lifecycle and minimal market activity ($2M spending, 427 annual claims). Roles are primarily defensive—focused on managing generic transition, maintaining legacy accounts, and ensuring supply continuity rather than growth or innovation.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.