NDAORALTABLET
Approved
Jul 1992
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
14
Data completeness
4/8 — Partial
NORVASC (amlodipine besylate) by Viatris (2) is (calcium ion antagonist or slow‑channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. First approved in 1992.
Drug data last refreshed 4h ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NORVASC (amlodipine besylate) is a calcium channel antagonist approved in 1992 for hypertension and angina. It works by inhibiting calcium ion influx into vascular smooth muscle and cardiac muscle cells, causing peripheral arterial vasodilation and reduced blood pressure. The drug is taken orally as a tablet and is effective for both exertional angina (by reducing cardiac workload) and vasospastic angina (by blocking coronary artery constriction).
$0.016BPart D
LOE ApproachingStable
As a mature product approaching loss of exclusivity, NORVASC brand teams are likely focusing on cost management, generic transition planning, and defending volume through value-based contracting rather than expansion.
Mechanism of Action
(calcium ion antagonist or slow‑channel blocker) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Experimental data suggest that amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac…
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.