NDATOPICALLOTION
Approved
May 1990
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
3/8 — Basic
NIX (permethrin) by Design Pharmaceuticals is clinical pharmacology permethrin, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods. First approved in 1990.
Drug data last refreshed 15h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NIX (permethrin) is a topical pyrethroid insecticide approved in 1990 for treating parasitic infestations including lice, scabies, and mites. It works by disrupting sodium channel currents in pest nerve cell membranes, causing delayed repolarization and paralysis. The drug is rapidly metabolized to inactive urinary metabolites with minimal systemic absorption (<2% of applied dose).
LOE Approaching
Product is in late lifecycle stage with approaching loss of exclusivity; expect downsizing or transition of commercial teams to brand defense and OTC channel management.
Mechanism of Action
CLINICAL PHARMACOLOGY Permethrin, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods. It acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization…
Pharmacologic Class:
Pyrethroid
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Natrunix in Combination With Methotrexate for Rheumatoid Arthritis Treatment
Started Jul 2026
108 enrolled
Rheumatoid Arthritis
Project PHOENIX: Molecular Signatures of Burn Pit Exposure
Started May 2026
1,000 enrolled
Burn Pit ExposureAirborne Hazard ExposureVeteran Health+4 more
PHOENIX: QL1706 Plus Chemotherapy and Bevacizumab in AGA-Resistant, PD-L1 ≥50% Non-Squamous NSCLC
Started Jan 2026
61 enrolled
Lung Adenocarcinoma
Augmented Reality BCI Longitudinal Study for Persons With ALS, Stroke, TBI and SCI Utilizing Cognixion + Apple Vision Pro
Started Oct 2025
10 enrolled
ALS (Amyotrophic Lateral Sclerosis)TBI Traumatic Brain InjurySCI - Spinal Cord Injury+1 more
Pilot Study of PHOENIX Wound Matrix® Impact on Chronic DFU Wound Microbiome
Started Mar 2025
11 enrolled
Diabetic Foot Ulcer
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.