NDAORALTABLET
Approved
Oct 1981
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
4/8 — Partial
MIDAMOR (amiloride hydrochloride) by Design Pharmaceuticals is clinical pharmacology amiloride hcl is a potassium-conserving (antikaliuretic) drug that possesses weak (compared with thiazide diuretics) natriuretic, diuretic, and antihypertensive activity. Approved for hypertension. First approved in 1981.
Drug data last refreshed 18h ago · AI intelligence enriched 3d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
MIDAMOR (amiloride HCl) is an oral potassium-conserving diuretic used to treat hypertension, often as an adjunct to thiazide or loop diuretics. It works by inhibiting sodium reabsorption in the distal convoluted tubule and collecting duct, reducing potassium and hydrogen secretion while maintaining serum potassium levels. The drug has weak natriuretic and diuretic effects compared to thiazides but provides significant electrolyte-sparing benefits.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30/100); brand team likely focused on retention strategies and limited growth initiatives.
Mechanism of Action
CLINICAL PHARMACOLOGY Amiloride HCl is a potassium-conserving (antikaliuretic) drug that possesses weak (compared with thiazide diuretics) natriuretic, diuretic, and antihypertensive activity. These effects have been partially additive to the effects of thiazide diuretics in some clinical studies.…
Indications (1)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.