NDATOPICALCREAM
Approved
Feb 1956
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
METI-DERM (prednisolone) by Merck & Co. is clinical pharmacology naturally occurring glucocorticoids (hydrocortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Approved for the following conditions: 1, systemic lupus erythematosus, dermatomyositis (polymyositis) and 4 more indications. First approved in 1956.
Drug data last refreshed 1h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
METI-DERM is a topical cream formulation of prednisolone, a synthetic glucocorticoid with potent anti-inflammatory properties. It is used to treat systemic autoimmune and inflammatory conditions including systemic lupus erythematosus, dermatomyositis, polymyalgia rheumatica, Sjögren's syndrome, relapsing polychondritis, and certain vasculitis cases. Prednisolone works by suppressing inflammatory processes, inhibiting immune cell production, and modulating glucocorticoid receptor signaling to reduce tissue inflammation and immune activation.
LOE Approaching
Product is approaching loss of exclusivity with moderate competitive pressure (30), indicating brand team focus will shift from growth to lifecycle management and defense.
Mechanism of Action
CLINICAL PHARMACOLOGY Naturally occurring glucocorticoids (hydrocortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs are primarily used for their potent anti-inflammatory effects in disorders of many…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.