NDAINJECTIONINJECTABLE
Approved
Aug 1947
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
METHADONE HYDROCHLORIDE (methadone hydrochloride) by Viatris is mechanism of action methadone hydrochloride is a mu-agonist; a synthetic opioid analgesic with multiple actions qualitatively similar to those of morphine, the most prominent of which involve the central nervous system and organs composed of smooth muscle. First approved in 1947.
Drug data last refreshed 10h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Methadone hydrochloride is a synthetic mu-agonist opioid analgesic used for pain management and opioid addiction treatment via maintenance or detoxification. It works by binding mu-opioid receptors in the central nervous system and may also act as an NMDA receptor antagonist. The drug is administered by injection and has a slower onset, more prolonged course, and milder withdrawal syndrome compared to morphine.
LOE Approaching
As a legacy product approaching loss of exclusivity, roles on this brand are likely focused on operational efficiency and lifecycle extension rather than growth or new launches.
Mechanism of Action
Mechanism of Action Methadone hydrochloride is a mu-agonist; a synthetic opioid analgesic with multiple actions qualitatively similar to those of morphine, the most prominent of which involve the central nervous system and organs composed of smooth muscle. The principal therapeutic uses for…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
Working on methadone as a professional means focusing on operational efficiency, compliance, and market access in a mature, LOE-stage product. Career growth is limited by the product's lifecycle stage, but roles offer deep expertise in opioid regulation, addiction medicine, and specialty pharmacy.
Regulatory Affairs Specialist
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.