NDAINHALATIONAEROSOL, METERED
Approved
Jan 1960
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
MEDIHALER ERGOTAMINE (ergotamine tartrate) by Teva is clinical pharmacology ergotamine is an alpha adrenergic blocking agent with a direct stimulating effect on the smooth muscle of peripheral and cranial blood vessels and produces depression of central vasomotor centers. Approved for migraine. First approved in 1960.
Drug data last refreshed 11h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
MEDIHALER ERGOTAMINE is an inhaled metered-dose aerosol containing ergotamine tartrate, an alpha-adrenergic blocking agent used to treat acute migraine headaches. The drug works by directly stimulating smooth muscle contraction in peripheral and cranial blood vessels while antagonizing serotonin, with added caffeine to enhance vasoconstrictive effects. The inhalation route bypasses first-pass hepatic metabolism, making it practical for migraine patients experiencing severe nausea and vomiting.
LOE Approaching
Product is approaching loss of exclusivity with moderate competitive pressure (30/100), signaling a contracting brand team focused on defensive strategies and volume retention.
Mechanism of Action
CLINICAL PHARMACOLOGY Ergotamine is an alpha adrenergic blocking agent with a direct stimulating effect on the smooth muscle of peripheral and cranial blood vessels and produces depression of central vasomotor centers. The compound also has the properties of serotonin antagonism. In comparison to…
Indications (1)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.