NDAORALCAPSULEPriority Review
Approved
Dec 2014
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
20
Data completeness
5/8 — Partial
Priority Review
LYNPARZA (olaparib) by AstraZeneca is poly(adp-ribose) polymerase inhibitors [moa]. First approved in 2014.
Drug data last refreshed Yesterday · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LYNPARZA (olaparib) is an oral poly(ADP-ribose) polymerase (PARP) inhibitor approved in 2014 for oncology indications, particularly in patients with BRCA-mutated cancers. It works by inhibiting PARP enzymes, leading to DNA damage and apoptosis in cancer cells with homologous recombination repair deficiencies. The drug has expanded significantly across multiple cancer types since its initial approval.
$0.487BPart D
Peak5.0 years to LOELYNPARZA remains in peak commercial phase with substantial Medicare Part D utilization, supporting stable commercial team operations and regional sales infrastructure.
Mechanism of Action
Poly(ADP-Ribose) Polymerase Inhibitors
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
PROLONG (PRostateOLaparibONcombinationGcc) Study
Started Jun 2026
75 enrolled
Metastatic Castration-resistant Prostate Cancer (mCRPC)
An Exploratory Study on the Use of Ipalotinib (Tislelizumab) Combined With Sunitinib and Olaparib for Neoadjuvant Therapy in HRD-positive Advanced Ovarian Cancer
Started Jun 2026
35 enrolled
Ovary Cancer
Cirtuvivint/Olaparib in Breast Cancer Susceptibility Gene/Homologous Recombination Deficiency Platinum Resistant Ovarian Cancer
Started Dec 2025
50 enrolled
Endometrioid Ovarian CancerPrimary Peritoneal CancerFallopian Tube Cancer
Durvalumab With or Without Olaparib in Patients With Endometrial Cancers Regulatory Post Marketing Surveillance
Started Sep 2025
50 enrolled
Endometrial Cancer
Investigating Idetrexed and Olaparib in Patients With Ovarian Cancer
Started Aug 2025
33 enrolled
High Grade Serous Ovarian Cancer
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.