NDAORALTABLET
Approved
Dec 2022
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
8
Data completeness
7/8 — Comprehensive
KRAZATI (adagrasib) by Bristol Myers Squibb is g12c that covalently binds to the mutant cysteine in kras g12c and locks the mutant kras protein in its inactive state that prevents downstream signaling without affecting wild-type kras protein. Approved for non-small cell lung cancer. First approved in 2022.
Drug data last refreshed 20h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
KRAZATI (adagrasib) is an oral small-molecule KRAS G12C inhibitor developed by Bristol Myers Squibb and approved in December 2022. It works by covalently binding to the mutant cysteine residue in KRAS G12C proteins, locking them in an inactive state and preventing downstream oncogenic signaling while sparing wild-type KRAS. The drug is indicated for metastatic non-small cell lung cancer (NSCLC) and metastatic colorectal cancer (CRC) with KRAS G12C mutations detected by FDA-approved testing, with demonstrated synergy when combined with cetuximab in CRC models.
$0.0BPart D
17.3 years to LOEMechanism of Action
G12C that covalently binds to the mutant cysteine in KRAS G12C and locks the mutant KRAS protein in its inactive state that prevents downstream signaling without affecting wild-type KRAS protein. Adagrasib inhibited tumor cell growth and viability in cells harboring KRAS G12C mutations and resulted…
Indications (1)
Clinical Trials (8)
A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer
Started Sep 2024
338 enrolled
Non-Small Cell Lung CancerKRAS G12C Lung Cancer
A Study of INCB099280 in Combination With Adagrasib in Adults With Advanced Solid Tumors Harboring a KRASG12C Mutation
Started Dec 2023
6 enrolled
Advanced Solid Tumors
A Study of BMS-986466 With Adagrasib With or Without Cetuximab in Participants With Kirsten Rat Sarcoma Virus Glycine 12 to Cysteine (KRAS G12C)-Mutant Solid Tumors
Started Nov 2023
5 enrolled
Advanced Solid Tumors
A Phase I Study of Adagrasib and Durvalumab for Treatment of Advanced Non-small Cell Lung Cancers and Gastro-intestinal Cancers Harboring KRAS G12C Mutations
Started Apr 2023
0Lung CancerGastro-intestinal Cancer
Neoadjuvant KRAS G12C Directed Therapy With Adagrasib (MRTX849) With or Without Nivolumab
Started Mar 2023
0Resectable Non-Small Cell Lung Cancer
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.