BLAINJECTIONINJECTABLEPriority Review
Approved
Dec 2004
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
19
Data completeness
4/8 — Partial
Priority Review
KEPIVANCE (palifermin) by Swedish Orphan Biovitrum is (fgf) family that binds to the kgf receptor. First approved in 2004.
Drug data last refreshed 43m ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
KEPIVANCE (palifermin) is a recombinant human fibroblast growth factor (FGF) that binds to the KGF receptor on epithelial cells to promote proliferation, differentiation, and migration. It is indicated for the reduction of oral mucositis in patients receiving myeloablative chemotherapy and/or radiation therapy for hematologic malignancies prior to hematopoietic stem cell support. The drug works by enhancing epithelial tissue repair and regeneration across multiple tissue types.
LOE Approaching
Product is approaching loss of exclusivity with a small linked job market of 68 positions, indicating a mature, specialized commercial footprint concentrated in regulatory and quality functions.
Mechanism of Action
(FGF) family that binds to the KGF receptor. Binding of KGF to its receptor has been reported to result in proliferation, differentiation, and migration of epithelial cells. The KGF receptor, one of four receptors in the FGF family, has been reported to be present on epithelial cells in many…
Pharmacologic Class:
Mucocutaneous Epithelial Cell Growth Factor
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.