NDAORALCAPSULE
Approved
Apr 2024
Lifecycle
Growth
Competitive Pressure
0/100
Clinical Trials
15
Data completeness
6/8 — Strong
INGREZZA SPRINKLE (valbenazine) by Neurocrine Biosciences is huntington's disease is unclear, but is thought to be mediated through the reversible inhibition of vesicular monoamine transporter 2 (vmat2), a transporter that regulates monoamine uptake from the cytoplasm to the synaptic vesicle for storage and release. First approved in 2024.
Drug data last refreshed 14h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
INGREZZA SPRINKLE (valbenazine) is an oral capsule approved in April 2024 for Huntington's disease, a neurodegenerative disorder. The drug works by reversibly inhibiting vesicular monoamine transporter 2 (VMAT2), reducing cytoplasmic monoamine levels and modulating synaptic neurotransmission. It represents a novel formulation option for patients requiring flexible dosing.
Growth14.1 years to LOE
Early-stage launch phase with expanding commercial infrastructure; opportunity for rapid team growth and market development in rare neurology segment.
Mechanism of Action
Huntington's disease is unclear, but is thought to be mediated through the reversible inhibition of vesicular monoamine transporter 2 (VMAT2), a transporter that regulates monoamine uptake from the cytoplasm to the synaptic vesicle for storage and release.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (15)
Valbenazine in Obsessive Compulsive Disorder
Started Jun 2026
30 enrolled
Obsessive-Compulsive Disorder
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
Started Aug 2025
50 enrolled
SchizophreniaSchizoaffective DisorderBipolar Disorder+2 more
Valbenazine Treatment of Tardive Dyskinesia in Adults With Intellectual/Developmental Disabilities
Started Jan 2025
0Tardive DyskinesiaIntellectual DisabilityDevelopmental Disabilities
Reduction of Demoralization in Patients With Tardive Dyskinesia After Treatment With Valbenazine
Started Oct 2024
0Tardive Dyskinesia
Long-term Study to Evaluate Safety and Tolerability of Valbenazine in Participants With Chorea Associated With Huntington Disease in Canada
Started Apr 2024
7 enrolled
Chorea, Huntington
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.