Tardive Dyskinesia

8
Pipeline Programs
4
Companies
4
Clinical Trials
4
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
1
1
5
Early DiscoveryClinical DevelopmentMarket

On Market (4)

Approved therapies currently available

UP
KEPPRAApproved
levetiracetam
UCB Pharma
oral2003
UP
KEPPRA XRApproved
levetiracetam
UCB Pharma
oral2008
U
LEVETIRACETAMApproved
levetiracetam
Unknown Company
oral2012
U
SPRITAMApproved
levetiracetam
Unknown Company
oral2015

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Teva
TevaIsrael - Petach Tikva
2 programs
1
1
Deutetrabenazine Oral CapsulePhase 41 trial
SD-809Phase 2/31 trial
Active Trials
NCT02195700Completed117Est. May 2015
NCT06997198Not Yet Recruiting25Est. Oct 2027
UP
UCB PharmaBelgium - Brussels
1 program
1
1
levetiracetamPhase 31 trial
Active Trials
NCT00291213Completed50
Medicure
MedicureBarbados - Holetown
1 program
1
Pyridoxal 5'-PhosphatePhase 21 trial
Active Trials
NCT00917293TerminatedEst. Aug 2014

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
TevaDeutetrabenazine Oral Capsule
TevaSD-809
MedicurePyridoxal 5'-Phosphate

Clinical Trials (4)

Total enrollment: 192 patients across 4 trials

NCT06997198TevaDeutetrabenazine Oral Capsule

Deutetrabenazine Treatment for Tardive Dyskinesia in Intellectual/Developmental Disabilities

Start: Mar 2026Est. completion: Oct 202725 patients
Phase 4Not Yet Recruiting

Levetiracetam Treatment of Tardive Dyskinesia

50 patients
Phase 3Completed

Aim to Reduce Movements in Tardive Dyskinesia

Start: Jun 2014Est. completion: May 2015117 patients
Phase 2/3Completed
NCT00917293MedicurePyridoxal 5'-Phosphate

Safety and Efficacy of Pyridoxal 5' -Phosphate in the Treatment of Tardive Dyskinesia

Start: May 2009Est. completion: Aug 2014
Phase 2Terminated

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
4 companies competing in this space