NDAVAGINALINSERT
Approved
May 2018
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
20
Data completeness
6/8 — Strong
IMVEXXY (estradiol) by Pfizer is estrogen receptor agonists [moa]. First approved in 2018.
Drug data last refreshed 12h ago · AI intelligence enriched 15h ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
IMVEXXY is a vaginal estradiol insert approved in 2018 for vaginal atrophy and related symptoms associated with menopause. It delivers estrogen directly to vaginal tissue via a dissolvable insert formulation, acting as an estrogen receptor agonist to restore vaginal epithelial health. The localized delivery mechanism minimizes systemic hormone exposure compared to traditional HRT.
$13MPart D
Peak7.2 years to LOEProduct is at peak lifecycle with modest Part D utilization (~$13M spending); commercial team likely focused on market penetration and patient awareness rather than defensive strategies.
Mechanism of Action
Estrogen Receptor Agonists
Pharmacologic Class:
Estrogen
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Cyclic vs. Constant Estradiol: Regimens' Effects on Brain Health
Started Jul 2026
40 enrolled
MenopauseHealthy AdultBrain+1 more
Evaluate the Effect of Vimseltinib on Pharmacokinetics of Combined Oral Contraceptive (Ethinyl Estradiol/Levonorgestrel)
Started Jun 2026
27 enrolled
Healthy Participants
A Trial to Examine the Interaction of Repinatrabit With Ethinyl Estradiol/Norethindrone, Metformin,Carbamazepine, Rosuvastatin, and Methotrexate When Administered Together
Started Mar 2026
48 enrolled
Healthy Volunteers
A Phase 1 Study to Assess the Effect of ABBV-722 on Ethinyl Estradiol and Levonorgestrel Drug Levels in Healthy Adult Female Participants
Started Mar 2026
15 enrolled
Healthy Volunteer
Estradiol-mediated Inflammation and Central Sensitization in the Pathophysiology of Endometriosis-associated Pelvic Pain
Started Dec 2025
130 enrolled
EndometriosisPelvic Pain
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.