NDAORALTABLET
Approved
Jan 1998
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
EXCEDRIN (MIGRAINE RELIEF) (acetaminophen, asprin, caffeine) by GSK is cyclooxygenase inhibitors [moa]. Approved for migraine. First approved in 1998.
Drug data last refreshed 16h ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Excedrin Migraine Relief is an over-the-counter oral tablet combining acetaminophen, aspirin, and caffeine to treat migraine headaches. The fixed-dose combination works through cyclooxygenase inhibition and caffeine-mediated cranial vasoconstriction to reduce pain and inflammation associated with migraine attacks. This classic NSAID-based formulation has been a consumer staple since 1998.
LOE Approaching
As loss of exclusivity looms, GSK's brand team faces consolidation pressure; focus shifts from growth to lifecycle extension and market defense against generics and prescription alternatives.
Mechanism of Action
Cyclooxygenase Inhibitors
Pharmacologic Class:
Nonsteroidal Anti-inflammatory Drug
Indications (1)
Career Relevance
Excedrin career roles center on OTC brand management and retail/pharmacy channel execution rather than clinical development; as LOE approaches, teams compress and shift focus to generic-vs.-branded defense strategies and market share protection. Career longevity on this product depends on willingness to work in mature brand management, cost optimization, and channel partnerships rather than innovation-driven initiatives.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.