NDAORALCAPSULE
Approved
May 2008
Lifecycle
Peak
Competitive Pressure
8/100
Clinical Trials
16
Data completeness
5/8 — Partial
ENTEREG (alvimopan) by Merck & Co. is μ-opioid receptor with a ki of 0. Approved for postoperative ileus. First approved in 2008.
Drug data last refreshed 19h ago
Mechanism of Action
μ-opioid receptor with a Ki of 0.4 nM (0.2 ng/mL) and no measurable opioid-agonist effects in standard pharmacologic assays. The dissociation of [H]-alvimopan from the human μ-opioid receptor is slower than that of other opioid ligands, consistent with its higher affinity for the receptor. At…
Indications (1)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.