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Postoperative Ileus

3
Pipeline Programs
5
Companies
6
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
1
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Norgine
NorgineAustria - Vienna
2 programs
1
1
TZP-101Phase 31 trial
TZP-101Phase 11 trial
Active Trials
NCT01668199Completed6Est. Mar 2012
NCT01710982Completed27Est. Apr 2012
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
1 program
1
IV MethylnaltrexonePhase 21 trial
Active Trials
NCT01367548Completed65Est. Dec 2004
Verona Pharma
Verona PharmaUK - London
1 program
Standard coffeeN/A1 trial
Active Trials
NCT04205058Unknown199Est. Dec 2021
Innovation Pharmaceuticals
1 program
enriched enteral nutritionN/A1 trial
Active Trials
NCT02175979Completed280Est. Dec 2017
T-Therapeutics
T-TherapeuticsUK - Cambridge
1 program
DAMPHASE_31 trial
Active Trials
NCT01863407UnknownEst. Nov 2014

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
T-TherapeuticsDAM
NorgineTZP-101
Bausch HealthIV Methylnaltrexone
NorgineTZP-101
Verona PharmaStandard coffee
Innovation Pharmaceuticalsenriched enteral nutrition

Clinical Trials (6)

Total enrollment: 577 patients across 6 trials

NCT01863407T-TherapeuticsDAM

Study of Dexamethasone-Allantoin-Metronidazole (DAM) Solution in the Treatment of Post-Operative Ileus (POI)

Start: Apr 2013Est. completion: Nov 2014
Phase 3Unknown
NCT01710982NorgineTZP-101

Study to Evaluate the Safety of Post-Operative TZP-101 (IV Ulimorelin) After Partial Bowel Resection

Start: Feb 2012Est. completion: Apr 201227 patients
Phase 3Completed
NCT01367548Bausch HealthIV Methylnaltrexone

Intravenous (IV) Methylnaltrexone (MNTX) in the Prevention of Post-Operative Ileus

Start: Jul 2003Est. completion: Dec 200465 patients
Phase 2Completed
NCT01668199NorgineTZP-101

A Study in Healthy Male Subjects Designed to Assess the Mass Balance Recovery and Pharmacokinetics of 14C TZP-101

Start: Feb 2012Est. completion: Mar 20126 patients
Phase 1Completed
NCT04205058Verona PharmaStandard coffee

Coffee After Pancreatic Surgery

Start: Sep 2019Est. completion: Dec 2021199 patients
N/AUnknown
NCT02175979Innovation Pharmaceuticalsenriched enteral nutrition

SANICS II Trial: Stimulation of the Autonomic Nervous System in Colorectal Surgery by Perioperative Nutrition

Start: Aug 2014Est. completion: Dec 2017280 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
5 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.