ELLIOTTS B SOLUTION
LOE Approachingsodium cation, sodium bicarbonate, anhydrous dextrose, magnesium sulfate, potassium chloride, calcium chloride, sodium phosphate
NDAINTRATHECALINJECTABLEPriority Review
Approved
Sep 1996
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
Priority Review
ELLIOTTS B SOLUTION (sodium cation, sodium bicarbonate, anhydrous dextrose, magnesium sulfate, potassium chloride, calcium chloride, sodium phosphate) is clinical pharmacology elliotts b solution provides a buffered salt solution for use as a diluent for the intrathecal administration of methotrexate sodium and cytarabine. Approved for leukemia, lymphoma. First approved in 1996.
Drug data last refreshed 13h ago · AI intelligence enriched Yesterday
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Elliott's B Solution is a buffered salt solution diluent formulated to mimic cerebrospinal fluid composition for intrathecal administration of methotrexate sodium and cytarabine in leukemia and lymphoma. The solution maintains pH, electrolyte balance, glucose content, and osmolarity comparable to native CSF, enabling safe central nervous system chemotherapy delivery. It functions as a critical enabling agent rather than a primary therapeutic, reducing neurotoxicity risk in CNS-directed cancer therapy.
LOE Approaching
This product is in late-stage lifecycle with approaching loss of exclusivity, indicating a mature brand team focused on defending market share rather than growth expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY Elliotts B Solution provides a buffered salt solution for use as a diluent for the intrathecal administration of methotrexate sodium and cytarabine. It has been demonstrated that Elliotts B Solution is comparable to cerebrospinal fluid in pH, electrolyte composition, glucose…
Indications (2)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
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