ELLIOTTS B SOLUTION
LOE Approachingsodium cation, sodium bicarbonate, anhydrous dextrose, magnesium sulfate, potassium chloride, calcium chloride, sodium phosphate
NDAINTRATHECALINJECTABLEPriority Review
Approved
Sep 1996
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
Priority Review
ELLIOTTS B SOLUTION (sodium cation, sodium bicarbonate, anhydrous dextrose, magnesium sulfate, potassium chloride, calcium chloride, sodium phosphate) is clinical pharmacology elliotts b solution provides a buffered salt solution for use as a diluent for the intrathecal administration of methotrexate sodium and cytarabine. Approved for leukemia, lymphoma. First approved in 1996.
Drug data last refreshed 15h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Elliott's B Solution is a buffered salt solution diluent formulated to mimic cerebrospinal fluid composition for intrathecal administration of chemotherapy agents methotrexate and cytarabine. It is used in the treatment of hematologic malignancies including leukemia and lymphoma, where CNS prophylaxis or treatment is required. The solution maintains pH, electrolyte balance, and osmolarity comparable to natural CSF, minimizing neurotoxicity during intrathecal chemotherapy delivery.
LOE Approaching
Established specialty product approaching loss of exclusivity with low competitive pressure (30%), indicating a focused, stable team managing a niche indication.
Mechanism of Action
CLINICAL PHARMACOLOGY Elliotts B Solution provides a buffered salt solution for use as a diluent for the intrathecal administration of methotrexate sodium and cytarabine. It has been demonstrated that Elliotts B Solution is comparable to cerebrospinal fluid in pH, electrolyte composition, glucose…
Indications (2)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
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