NDAORALTABLET
Approved
Aug 2017
Lifecycle
Peak
Competitive Pressure
0/100
Data completeness
4/8 — Partial
DUZALLO (allopurinol; lesinurad) by Ironwood Pharmaceuticals is allopurinol acts on purine catabolism, without disrupting the biosynthesis of purines. Approved for leukemia, lymphoma. First approved in 2017.
Drug data last refreshed 19h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
DUZALLO is a fixed-dose oral combination of allopurinol and lesinurad approved in 2017 for hyperuricemia management in patients with leukemia and lymphoma. Allopurinol inhibits xanthine oxidase to reduce uric acid production, while lesinurad enhances uric acid excretion via renal urate transporters. The dual mechanism provides synergistic uric acid lowering for patients at high risk of tumor lysis syndrome.
Peak5.8 years to LOE
Product is at peak commercial maturity with a specialized indication; regulatory team involvement remains moderate due to ongoing patent portfolio management through 2032.
Mechanism of Action
Allopurinol acts on purine catabolism, without disrupting the biosynthesis of purines. It reduces the production of uric acid by inhibiting the biochemical reactions immediately preceding its formation. Allopurinol is a structural analogue of the natural purine base, hypoxanthine. It is an…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.